Colombia

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Focus: Vector-borne and emerging infections(Leishmaniasis Malaria, Dengue),MDR/XDR TB, congenital and secondary syphilis,  hospital associated infections and drug resistance

Affiliation: Centro Internacional de Entrenamiento e Investigaciones Medicas (CIDEIM); Yale School of Public Health
Contacts: Nancy G. Saravia, PhD, saravian@cideim.org.co; Diane McMahon-Pratt, diane.mcmahon-pratt@yale.edu
Projects: The training program will be supported on-site in Cali, Colombia by CIDEIM. Training sites include CIDEIM headquarters in Cali and our clinical research facility in Tumaco on the Pacific coast. In addition training activities are conducted in collaboration with the Universidad del Valle Faculty of Health and Hospital, and the Fundacion Valle de Lili Clinic in Cali.

CIDEIM investigators and faculty of the Yale School of Public have jointly conducted US/NIH supported research and training since 2003 including an ICIDR Program, Gorgas Fellowship,  an ongoing R01 Project and  Fogarty NIH-sponsored Global Infectious Disease Training Program (Project No. 2D43TW006589). CIDEIM has hosted Fellows of the Yale Downs Fellowship program, Fulbright, and Howard Hughes. On-going projects in which fellows may participate include:

  1. NIAID- supported project (R01- AI093775). “Improvement of Treatment of American Cutaneous Leishmaniasis by Immunomodulation”. This study immunologically characterizes healing and non-healing responses during treatment of human cutaneous leishmaniasis and modification of the in vitro adaptive and innate response by immunomodulators coupled to nanostructures in parallel with experimental evaluation of these immunomodulators in a murine model of chronic cutaneous leishmaniasis.
  1. NIAID- supported project (R01- AI104823). “Macrophage drug transport and metabolism in the outcome of antileishmania therapy”. This project seeks to unravel the role of macrophages on the outcome of treatment of cutaneous leishmaniasis caused by species of the Viannia subgenus by identifying host cell specific pharmacological correlates of the therapeutic response to antileishmanial drugs.
  1. COLCIENCIAS-supported project (Contract 250-2010). “Pharmacokinetics of Miltefosine in Children and Adults: Implications for the Treatment of Cutaneous Leishmaniasis in Colombia”.  This is a population pharmacokinetics (PopPK) study of miltefosine in adult and pediatric cutaneous leishmaniasis patients conducted in collaboration with the School of Pharmacy of the University of Amsterdam.
  2. COLCIENCIAS-supported project (Contract 253-2010) “Ganancia terapéutica en el tratamiento de la leishmaniasis cutánea Americana con la adición del inmunomodulador pentoxifilina”. The study is an “add-on” clinical trial of the combination of pentoxyphylline and meglumine antimoniate in patients with cutaneous leishmaniasis that seeks to determine whether the addition of pentoxyphylline to standard of care treatment can improve and accelerate the clinical and parasitological response and reduce relapse of disease.
  3. COLCIENCIAS-supported project (cod: 222956933229) “Rol de las células NK en la respuesta inmune a Treponema pallidum en pacientes con sífilis venérea y sífilis gestacional”. This project will functionally characterize NK cells in pregnant women who are diagnosed to have syphilis.  The results are important to unstanding the persistence of infection in venereal syphilis and pathogenesis in congenital syphilis.
  4. Programa AEDES Colombia “Desarrollo, implementación y evaluación de un sistema prototipo que integra vigilancia, diseño de estrategias de prevención e intervención y evaluación de impacto para el control de dengue”. This Project will undertake an integrated analysis of the variables associated with the transmission (epidemiologic, entomologic and social) of dengue virus that facilitate timely and informed decisions for the design and evaluation of prevention and control strategies that respond to local determinants of transmission.
  1. COLCIENCIAS-supported Project. “Pharmacogenomics of the therapeutic response to antileishmanial drug treatment in Colombia”. This project seeks to identify pharmacogenomic biomarkers of the therapeutic response to antimonial therapy against cutaneous leishmaniasis in Colombia.
  1. COLCIENCIAS-supported project. “Evaluation of a prediction rule with mobile for early detection and referral of cutaneous leishmaniasis in Colombian rural communities”. This project seeks to implement a prediction rule tool for the diagnosis of cutaneous leishmaniasis using cellular mobile devices to enhance the early diagnosis of the disease in affected communities.
  2. COLCIENCIAS-supported project. “Evaluación de mecanismos de respuesta inmune innata asociados con la susceptibilidad al virus Dengue en poblaciones de Aedes aegypti colectados en campo”. This Project will evaluate the role of apoptosis in the reduction of dengue virus infection in natural Aedes aegypti populationswith divergent vector compentence with the objective of identifying target molecules that inhibit transmission of the virus by this vector species.

Webpages for sites and research programs:
CIDEIM:            http://www.cideim.org.co/cideim/en.html
http://publichealth.yale.edu/people/diane_mcmahon-pratt.profile      

Qualifications of potential trainees: Medical graduates (MD; MSc, MPH and PhD students and Postdoctoral Fellows