The NIH's John Fogarty International Center sponsors research training grants that provide funding to train researchers, building sustainable expertise in low-and middle-income countries. Over the life of these grants, over 200 public health professionals and researchers have received mentorship and training from Yale’s world class faculty.
Primary Collaborating Institution
Trypanosomiasis Research Center
July 2010 - June 2014
Russia (St. Petersburg)
September 1998 - May 2016
Biomedical Center and St. Petersburg State University.
Regional Non-Governmental Organization of Social Projects in the Sphere of Population’s Wellbeing (STELLIT)
(P.I. of the Yale subcontract)
July 2004 - March 2015
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control
|5. Global Health Equity Scholars Program at Yale University|
Yale Sites: Brazil, China, Ethiopia, Russia, Uganda, Ukraine
Affiliated Sites: Bangladesh, China, India,Kenya, Nicaragua, Zimbabwe
April 2012-February 2017
Centro Internacional de Entrenamiento e Investigaciones Médicas
|7. Research Ethics Training and Curriculum Development Program with China||Khoshnood, Kaveh||China (Changsha)|
July 2011 - May 2016
South Central University, Xiangya School of Medicine
1. Aksoy, Serap
Tsetse Transmitted African Trypanosomiasis
Tsetse transmitted Human African Trypanosomiasis (HAT) has re-emerged and poses a major public health crises in Sub Sahara. There are no vaccines and efficacious drugs for control of parasite infections in the mammalian host. In contrast, control of the vector insect tsetse populations can effectively break the disease cycle. Extensive resources have been generated in the developed country laboratories with respect to tsetse genomics/genetics that can immediately improve the existing vector control tools, while promising the development of future strategies. The ability of products resulting from high-tech research to reach field implementation stages requires the presence of endemic country scientists who are. well-informed in the full potential of the developed technologies, who can evaluate the pros and cons of these solutions, and who can present these perspectives to the general public and to the involved government agencies. In this training program, Yale University scientists are working with the Trypanosomiasis Research Center (TRC) in Kenya to strengthen the biomedical capacity and to acquire and implement the recent advances in applied vector genomics, genetics and bioinformatics to enhance the existing Human African Trypanosomiasis (HAT) control/management tools. TRC has been identified by a World Health Organization competitive initiative as the lead organization in Africa to coordinate the continent-wide capacity strengthening activities for HAT. A regional network (Eastern African Network of Trypanosomiasis, EANETT) consisting of the lead institutions with governmental mandates to work on HAT in Kenya, Uganda, Tanzania, Sudan and Malawi has already made considerable progress in building south-south initiatives. The specific objectives of this program are to: 1) Develop expertise at TRC and their associates to address mechanisms of parasite transmission biology, genetics of vector competence, population biology, and bioinformatics. 2) Strengthen collaborations with the laboratories in the endemic countries in Africa to enable transfer of new technologies and tools relevant for HAT control and promote their integration into the on-going disease control programs. 3) Develop training modules (seminars, workshops and mentored research activities) to increase research capacity for HAT in Africa with a specific focus on vector biology.
2. Aksoy, Serap
Evidence Based Control Strategies of Sleeping Sickness Vectors
This Fogarty International Research Collaboration award (FIRCA) proposal is on tsetse fly population genetics in order to support the ongoing Human African Trypanosomiasis (HAT) control activities in East Africa. The parent grant (NIAID R01Al068932, 01/01/2008 to 12/31/2012) addresses the molecular and ecological aspects of the two HAT disease belts (gambiense and rhodesiense) in Uganda with a focus on population and evolutionary genetics of tsetse flies and their parasites and endosymbionts. The co- investigator of this FIRCA, Dr. Johnson Ouma, is an experienced tsetse population geneticist who is now the head of tsetse genomic research and Deputy Director of the national Trypanosomiasis Research Center (TRC) in Kenya. Kenya is at risk of HAT outbreaks due to ongoing epidemics in neighboring Uganda and increased movement of people and cattle (known reservoirs for Trypanosoma brucei rhodesiense). Earlier tsetse control efforts in the Lake Victoria basin and in the southern Rift Valley were unsustainable and these regions rapidly became repopulated. It is unknown if the extant G. pallidipes vector populations in Lambwe originated through reinvasion from neighboring populations, or through incomplete elimination of local populations that existed below thresholds of detection. Efforts are underway once again to eliminate G. pallidipes from Lambwe valley and surrounding areas. This project has three aims to: 1) estimate rates of gene flow and degrees of genetic differentiation among G. pallidipes populations around the Lake Victoria basin and in southern Rift Valley, 2) estimate local levels of temporal genetic differentiation and dynamics of G. pallidipes populations from the Lambwe and Nguruman valleys and 3) understand the circulating trypanosome parasite diversity isolated from flies/humans and known reservoir animals in the Lambwe valley. Results will help understand the breeding pattern of G. pallidipes populations in East Africa, and thus identify populations that can serve as potential sources of immigrants into Nguruman and Lambwe. This knowledge is important to the ongoing and planned tsetse control programs and can help develop methods for inclusion or exclusion of adjacent populations to the target population during vector suppression efforts. Knowledge on parasite strains in circulation will also help better understand disease risk and epidemiology.
3. Heimer, Robert
Training and Research in HIV Prevention in Russia
During the past decade we have concentrated our efforts in St. Petersburg, Russia training young behavioral and medical scientists to participate in interdisciplinary HIV epidemiological, behavioral, and prevention research. Our most successful trainees - those who have made significant contributions to past and ongoing research collaborations - have been university-affiliated junior faculty members who conduct their research in either non-governmental organizations, research institutes, or branches of the Russian Academy of Sciences. Building on these successes, we will continue to provide interdisciplinary mentored research training to build cadres of research competence at these institutions and simultaneously develop the necessary interdisciplinary collaborations to succeed in building research teams to conduct epidemiological, behavioral, and prevention research in St. Petersburg and more broadly in the Russian Federation. We have identified five focus areas for research training: primary prevention for high-risk populations, secondary HIV prevention for HIV positives, health services research, nursing research, and translational research. Our program is allowing United States scientists to build partnerships with their counterparts in St. Petersburg to train young and emerging scientists to conduct meaningful research in primar and secondary HIV prevention, nursing research and health services and translational research. Our trainees are well-trained, motivated, and successful researchers who possess the interdisciplinary competencies to succeed as research scientists and make productive contributions in responding to the HIV/AIDS epidemic in Russia, which remains one of the fastest growing in the world.
4. Khoshnood, Kaveh
Multidisciplinary HIV and TB Implementation Sciences Training in China
The goals of the Multidisciplinary HIV and TB Implementation Sciences Training in China (China ICOHRTA2) are to build on the existing China ICOHRTA to further strengthen the capacity of the Chinese Center for Disease Control (CCDC) to conduct training in implementation science and to facilitate its establishment as a regional leader in research and training for HIV and TB prevention, care and treatment. The RTU administering China ICOHRTA comprises CCDC, UCLA and Yale University. China ICOHRTA2 will achieve these goals by designing and implementing a training program to close critical gaps in research and implementation sciences skills and knowledge, and achieve maximum long-term impact through further developing and expanding a cadre of highly trained research scientists. China ICOHRTA2 will have degree and non-degree components of varying duration available to different types of HIV and TB scientists and health professionals. Degree-related training is available to Ph.D., M.S. and M.P.H. candidates in health sciences. Non-degree training is available to senior staff and post-doctoral candidates from national level HIV and TB programs and includes; (1) senior staff training, (2) post-doctoral studies, (3) mentored studies and (4) workshops. In addition mentored studies and workshops are open to degree candidates and all Chinese HIV and TB health professionals via competitive selection. PUBLIC HEALTH RELEVANCE: Program requirements include (but are not restricted to) coursework, an internship at a national HIV or TB program, a research project over the course of 36 months and participation in various workshops. Senior staff trainees, post-doctoral candidates and eligible Ph.D. students will carry out coursework at the CCDC and UCLA or Yale, and M.S. and M.P.H. students will study only at CCDC. 13 degree candidates and 44 medium to long-term non-degree trainees have successfully completed the first China ICOHRTA program, and 442 people have attended workshops. China ICOHRTA trainees have published 95 peer-reviewed articles, 7 textbooks and updated curriculum at 7 institutions of higher learning.
The GHES Program is an initiative between Yale University, University of California at Berkeley, and Stanford and Florida International Universities, to support one year research training of post and predoctoral fellows at 12 partnering international institutions. The overall goal of the program, sponsored by the Fogarty International Center and affiliated NIH institutes (R25 TW009338), is to generate a new and young cadre of global health researchers, educators, and professionals who will be prepared to address the new challenges in global health.
The GHES Program aims to train fellows in innovative, interdisciplinary approaches to addressing health needs and promoting social equity. A major focus of the program is the health challenges which have emerged due to the rapid growth of slum settlements in both urban and rural settings of low and middle-income countries. Factors associated with chronic, non-communicable, as well as infectious diseases, environmental health hazards, risks specific to women and children, intentional and unintentional injuries, and mental disorders are potential areas of research that will be supported under this program. Furthermore, the program supports implementation research focused on providing accessible and high quality health care services at all levels in resource-limited settings.
6. McMahon-Pratt, Diane
Translational Research Training on Leishmaniasis & Emerging Infectious Diseases
7. Zheng, Tongzhang
Research Training for Cancer Epidemiology & Biostatistics in China
Following the rapid economic development and the severe environmental deterioration during the past three decades, human cancer risk has been increasing rapidly in China. Cancer now is the number one killer in China and the costs for cancer treatment in 2006 reached more than 20% of the annual total medical costs in China, and this number is actually considered to be seriously underestimated. Facing the grave consequence of the ever increasing cancer burden in China; realizing that nationwide deterioration in environmental conditions and human health could jeopardize the economic development, the Chinese government has taken major steps to prevent and control cancer. China, however, faces many challenges in confronting and battling the war against cancer. One of the major shortcomings for cancer prevention and control in China today is the severe lack of well-trained personnel in all major areas of cancer studies. The primary goal of this program is to build a center of excellence in research and teaching in cancer studies within the Cancer Institute, Chinese Academy of Medical Sciences (CI-CAMS, the designated China National Cancer Center), which is mandated by the central government to be responsible for China's cancer prevention and control. The program is (1) training scientists urgently needed in the CI-CAMS to develop appropriate strategies to better understand and more effectively respond to the emerging threat from the increasing cancer burden in China; (2) building an infrastructure that will allow CI-CAMS to function as a national center for teaching and research in cancer-related studies; and (3) strengthening China's National Cancer Registration Office to function as a national center of excellence for coordinating and monitoring China's cancer registration. The training goals will be achieved through trainees, selected from faculty and existing pre/post-doctoral programs at CI-CAMS, who will receive education and mentoring at Yale School of Public Health (YSPH) through long-term/intermediate/short-term training or workshops and internet-based tutorial system. The training will emphasize principles and methods in major areas of cancer epidemiology and biostatistics. This training program will be administered by a Program Faculty with representation from both CI-CAMS and Yale University. Yale University, YSPH in particular, has a strong history of prior research and training collaborations with China. We anticipate that trainees of this program will be uniquely qualified to be future leaders in the field of cancer research in China.
8. Khoshnood, Kaveh
Research Ethics Training and Curriculum Development Program with China
We propose a comprehensive multi-disciplinary Research Ethics Training and Curriculum Development Program that builds on the success of our extensive collaborations with Central South University, Xiangya School of Medicine, a leading academic institution in China. We have assembled a team of seasoned investigators from the United States and China with extensive experience in curriculum development, conduct and evaluation of international research projects as well as in training programs, mentoring international scholars and have carefully designed a program that is responsive to the short-term and long-term needs of the host country institution. The training program will develop and disseminate graduate level curricula in research ethics; provide long-term (18 months) and medium-term (10 months) training to 11 Chinese researchers and health professionals in multi-disciplinary research methodologies, bioethics and ethical review of research; offer intensive short–courses and workshops on research methods, grant and manuscript writing and selected research ethics topics; enhance human subjects protection and strengthen the capacity of Institutional Review Boards at Xiangya School of Medicine and Yale University to review research protocols. We believe the Chinese scholars trained through this program will influence research ethics policy and practice throughout China in the years to come.