Lingeng Lu, MD, PhD

Research Scientist in Epidemiology (Chronic Diseases)

Research Interests

Bacteria; Chronic Disease; Epidemiology; Hepatitis Viruses; Molecular Biology; Neoplasms; Prognosis; RNA Viruses; Virus Diseases; Survivors; Early Diagnosis

Research Organizations

School of Public Health: Chronic Disease Epidemiology

Faculty Research

Yale Cancer Center: Cancer Prevention and Control

Research Summary

Dr. Lu’s research interests focus on etiology, prognosis and diagnosis as well as survivorship of chronic diseases including cancer, metabolic syndrome, aging, HIV/ADIS and mental health. His research work integrates molecular biology, bioinformatics and epidemiology methods into investigating genetic, epigenetic and environmental factors in chronic diseases. His recent work includes 1)the assessment of epigenetic (non-coding RNA (miRNAs and lncRNAs), DNA methylation) and genetic markers and ovarian, breast and pancreatic cancer prognosis; 2) the understanding of genetic and environmental factors, as well as their interactions in the risk of pancreatic, esophageal, gastric, liver, bladder, brain and endometrial liver cancer; 3) the functional studies of genetic variations in human diseases; 4) the lifestyle intervention and cancer-related molecular markers including non-coding RNAs; 5) circulating exosomal miRNAs and HIV-associated neurological disorder; 6) Environmental endocrine interrupters and persistent organic pollutants and human health; 7) clinical trials of diabetes-related complications; 8) circulating exosomal proteins and early detection of ovarian and pancreatic cancers; 9) telomere length machinery and HIV treatment-related toxicity.

Extensive Research Description

1. Non-coding RNA (miRNAs, and lncRNAs) in cancer risk and progression
2. DNA methylation in cancer risk and progression
3. Genome-wide association study on endometrial, pancreatic, brain and liver cancer

4. Case-control studies of endometrial, liver, bladder, brain, gastric, esophageal, pancreatic cancer etiologic factors

5. Circulating exosomal miRNAs and HIV-associated neurological disorder

6. Circulating exosomal proteins and early detection of ovarian and pancreatic cancer

7. Growth factors and non-coding RNAs in diabetes and its related complications

8. Environmental pollution and hormone toxicity.

9. Exercise and healthy living in breast and ovarian cancer survivors

10. RNA modification and its associated genes in chronic diseases

11. Microbiome and human health

12. Immunotherapy and T cell activation

Selected Publications

Full List of PubMed Publications

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Contact Info

Lingeng Lu, MD, PhD
Office Location
Laboratory of Epidemiology and Public Health (LEPH)
60 College Street, Ste 706

New Haven, CT 06510
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Mailing Address
PO Box 208034
60 College Street

New Haven, CT 06520-8034