Public Health; Statistics; Biostatistics
Program for Applied Translational Research (PATR)
My primary research interests lie in the development and application of statistical methods for biological responses that vary in time and occasion, for example: biomarker readings over time; gene expression profiles in different cell lines and under different biological conditions; and tumor recurrence. My biostatistical research areas include: joint modeling of longitudinal responses and event process; latent class models with random effects; and analysis of longitudinal responses in the presence of missing and confounding data. I am collaborating with researchers in cancer, nutrition, health service evaluation and psychiatry.
Specialized Terms: Statistical methods for time-varying biological responses
- Lin, H.Q., Guo, Z.C., Peduzzi, P.N., Gill, T.M., and Allore, H.A. A Semiparametric Transition Model with Latent Traits for Longitudinal Multistate Data. Biometrics, in press.
- Lin, H.Q., Feng, Z., Yu, Y., Zheng, Y., Shivapurkar, N., and Gazdar, A.F. Application of Multidimensional Selective Item Response Regression Model for Studying Multiple Gene Methylation in SV40 Oncogenic Pathways. Journal of the American Statistical Association, in press, 2007.
- Lin, H.Q., Scharfstein, D.O., and Rosenheck, R.A. Analysis of longitudinal data with informative follow-up. Journal of the Royal Statistical Society Series B 66(3): 791-813, 2004.
- Lin, H.Q., McCulloch, C.E., and Rosenheck, R.A. Latent pattern mixture model for informative intermittent missing data in longitudinal studies. Biometrics 60(2): 295-305, 2004.
- Lin, H.Q., McCulloch, C.E., and Mayne, S.T. Maximum likelihood estimation in the joint analysis of time-to-event and multiple longitudinal variables. Statistics in Medicine 21(16): 2369-2382, 2002
- Lin, H.Q., Turnbull, B.W., McCulloch, C.E. and Slate, E.H. Latent class models for joint analysis of longitudinal biomarker and event process data. Journal of the American Statistical Association 457: 53-65, 2002.
- Lin, H.Q., Yeh, C.B., Peterson, B.S., et al. Assessment of symptom exacerbations in a longitudinal study of children with Tourette syndrome or obsessive-compulsive disorder. Journal of the American Academy of Child & Adolescent Psychiatry 41(9): 1070-1077, 2002.
- Lin, H.Q., McCulloch, C.E., Turnbull, B.W., Slate, E.H., and Clark, L.C. A latent class mixed model for analyzing biomarker trajectories with irregularly scheduled observations. Statistics in Medicine 19: 1303-1318, 2000.