Public Health Interests
Mutualistic and parasitic associations are widespread in nature and represent a driving force in evolution. However, the mechanisms underlying organisms' co-evolution through these interactions have just started to be investigated, and thus remain unclear. My research interests focus on understanding how the close association between several organisms impacts their mutual evolution.
My work on the tsetse fly focuses on exploring how pattern recognition receptors interact with the tsetse microbial partners. Especially, I am studying the role of the peptidoglycan recognition proteins (PGRPs) in the fly refractoriness against the trypanosomes protozoan parasite.
- Masson F, Vallier A, Vigneron A, Balmand S, Vincent-Monegat C, Zaidman-Remy A, Heddi A. Systemic Infection Generates a Local-Like Immune Response of the Bacteriome Organ in Insect Symbiosis. Journal of innate immunity. 2015;(in press). doi: 10.1159/000368
- Vigneron A, Masson F, Vallier A, Balmand S, Rey M, Vincent-Monegat C, Aksoy E, Aubailly-Giraud E, Zaidman-Remy A, Heddi A. Insects recycle endosymbionts when the benefit is over. Current biology. 2014;24(19):2267-73. doi: 10.1016/j.cub.2014.07.065. PMID:
- Vigneron A, Charif D, Vincent-Monegat C, Vallier A, Gavory F, Wincker P, Heddi A. Host gene response to endosymbiont and pathogen in the cereal weevil Sitophilus oryzae. BMC microbiology. 2011;12 Suppl 1, S14. doi: 10.1186/1471-2180-12-S1-S14. PMID: 22375
- Login FH, Balmand S, Vallier A, Vincent-Monegat C, Vigneron A, Weiss-Gayet M, Rochat D, Heddi A. Antimicrobial peptides keep insect endosymbionts under control. Science. 2014;334(6054):362-5. doi: 10.1126/science.1209728. PMID: 22021855.