B). Heatmap showing the clustering results by KEGG pathways using MCLUST. The color represents the clustering assignment of each sample by the KEGG pathways. C). Pathway based distance matrix among the clusters. The color of entry represents the pathway based distance between the corresponding two samples. Red represents a small distance (samples are strongly related) and white represents longer distance showing the strength of the clusters (samples are weakly related). Samples within TEA cluster 3 are the most strongly related and most homogeneous, followed by cluster 1 and 2, respectively.