Eugene D Shapiro, MD

Professor of Pediatrics (General Pediatrics) and of Epidemiology (Microbial Diseases); Deputy Director, Investigative Medicine Program; Co-Director of Education, of KL-2 Mentored Clinical Scholar Program and of Child Health Research, Yale Center for Clinical Investigation; Associate Chair for Clinical Translational and Educational Research, Department of Pediatrics

Research Interests

Lyme Disease; Vaccines; Infectious Disease Medicine

Research Summary

The effectiveness of vaccines in clinical practice; Prevention, diagnosis and treatment of Lyme disease; clinical epidemiology; case-control studies

Extensive Research Description

Clinical epidemiologic research on the effectiveness of vaccines, prevention, diagnosis and treatment of Lyme disease.

Management of patients with medically unexplained symptoms presenting as Lyme disease;

Selected Publications

  • Feder HM Jr, Johnson BJB, O’Connell S, Shapiro ED, Steere AC, Wormser GP, et al. A critical appraisal of “Chronic Lyme Disease.” N Engl J Med 2007;357:1422-30
  • Wormser GP, Dattwyler RJ, Shapiro ED, et al. The clinical assessment, treatment and prevention of Lyme disease, human granulocytic Anaplasmosis, and Babesiosis: Clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis
  • Vázquez M, LaRussa PS, Gershon AA, Niccolai LM, Muehlenbein CE, Steinberg SP, Shapiro ED. Effectiveness of varicella vaccine over time. JAMA 2004; 291:851-855.
  • Shapiro ED. Case-control studies of the effectiveness of vaccines: Validity and assessment of bias. Pediatr Infect Dis J 2004;23:127-31.
  • Vázquez M, LaRussa PS, Gershon AA, Steinberg SP, Freudigman K, Shapiro ED. Effectiveness of Varicella Vaccine in Clinical Practice. N Engl J Med 2001;344:955-60.
  • Seltzer EG, Shapiro ED. Misdiagnosis of Lyme disease: When not to order serologic tests. Pediatr Infect Dis J 1996;15:762-763.

Edit this profile

Contact Info

Eugene D Shapiro, MD
Patient Care Locations
Yale Pediatric Infectious DiseaseYale-New Haven Children's Hospital
1 Park Street, Ste West Pavilion - 2nd Floor

New Haven, CT 06504
Yale Pediatric Infectious DiseaseYale-New Haven Hospital
20 York Street

New Haven, CT 06510
Office Location
Dana Clinic Building
789 Howard Avenue, Ste 14 C

New Haven, CT 06519
Mailing Address
PO Box 208064
New Haven, CT 06520-8064

Curriculum Vitae