Brian Paul Leaderer MPH, PhD

Susan Dwight Bliss Professor of Epidemiology (Environmental Health) and Professor of Forestry And Environmental Studies; Deputy Dean of Public Health

Research Interests

Exposures to air contaminants; Air quality issues

Current Projects

  • Traffic and Respiratory Health
  • Indoor and Outdoor NO2 and Asthma Severity in Children
  • Asthma Severity in Children and Fine Particle Composition
  • Gene-Environment Interactions in Asthma Development
  • Genetic and Environmental Risk Factors in Asthma Severity
  • The Yale Center for Public Health Preparedness.

Research Summary

Dr. Leaderer's research interests are assessing exposures to air contaminants and assessing the health impact resulting from those exposures in both controlled human and epidemiological studies. His research is interdisciplinary in nature, typically focusing on indoor air quality issues, its purpose to establish a close link between exposure assessment and health and comfort effects measured in both chambers and in epidemiologic studies.

Within the context of assessing exposures, his work includes developing a theoretical framework for exposure assessment, determining the type and quantity of health related contaminants emitted from sources, assessing environmental concentrations and the factors impacting those concentrations, developing monitoring and modeling techniques and formulating strategies to assess exposures in epidemiologic studies.

Dr. Leaderer is Principal Investigator on three environmental epidemiologic studies:

  1. Prospective study investigating the role of indoor and outdoor air contaminant exposures on daily respiratory symptoms in 918 infants and their nonsmoking mothers;
  2. A prospective study of the environmental risk factors in the development of asthma in a population of 1,000 infants followed from birth to age 10; and
  3. A prospective study of the role of indoor allergens and air contaminants (indoor and outdoor) on the severity of asthma in 1,000 asthmatic children between the ages of 5 and 11.

He is also a co-investigator on several other environmental epidemiologic studies.

Selected Publications

  • Bell ML, Ebisu K, Leaderer BP, Gent JF, Lee HJ, Koutrakis P, Wang Y, Dominici F, Peng RD. Associations of PM2.5 Constituents and Sources with Hospital Admissions: Analysis of Four Counties in Connecticut and Massachusetts (USA) for Persons = 65 Years of Age. Environmental Health Perspectives. 2014 Feb; 122(2):138-44. doi: 10.1289/ehp.1306656. Epub 2013 Nov 6.
  • Belanger K, Holford TR, Gent JF, Hill ME, Kezik JM, Leaderer BP. Household Levels of Nitrogen Dioxide and Pediatric Asthma Severity. Epidemiology. 2013 Mar; 24(2):320-30.
  • Zhang L, Guan Y, Leaderer BP, Holford TR. Estimating daily nitrogen dioxide level: Exploring traffic effects. Annals of Applied Statistics. 2013; 7(3):1763-1777.
  • Bell ML, Belanger K, Ebisu K, Gent JF, Leaderer BP. Relationship between birth weight and exposure to airborne fine particulate potassium and titanium during gestation. Environ Res. 2012 Aug; 117:83-9.
  • DellaValle CT, Triche EW, Leaderer BP, Bell MB. Effects of Ambient Pollen Concentrations on Frequency and Severity of Asthma Symptoms Among Asthmatic Children. Epidemiology. 2012; 23(1):55-63.
  • Gent JF, Kezik JM, Hill ME, Tsai E, Li D-W, Leaderer BP. Household mold and dust allergens: Exposure, sensitization and childhood asthma morbidity. Environ Res., 2012 Oct; 118:86-93. doi:10.1016/j.envres.2012.07.005.
  • Fu A, Leaderer BP, Gent JF, Leaderer D, Zhu Y. An environmental epigenetic study of ADRB2 5’-UTR methylation and childhood asthma severity. Clinical & Experimental Allergy. 2012 Nov; 42(11):1575-81.
  • Triche EW, Lundsberg LS, Wickner PG, Belanger K, Leaderer BP, Bracken MB. Association of maternal anemia with increased wheeze and asthma in children. Ann Allergy Asthma Immunol. 2011;106(2):131:139.e1.
  • Lee HJ, Gent JF, Leaderer BP, Koutrakis P. Spatial and temporal variability of fine particle composition and source types in five cities of Connecticut and Massachusetts. Sci Total Environ. 2011; 409(11):2133-42.
  • Ebisu K, Holford TR, Belanger K, Leaderer BP, Bell ML. Urban land-use and respiratory symptoms in infants, Environ Res. 2011; 111(5):677-84.


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