Bonnie Elyssa Gould Rothberg, MD, PhD, MPH

Assistant Professor of Medicine (Medical Oncology)

Research Interests

Chronic Disease; Epidemiology; Immunohistochemistry; Lung Neoplasms; Medical Oncology; Melanoma; Pancreatic Neoplasms; Pathology; Tuberous Sclerosis; Genomics; Biomarkers, Pharmacological

Public Health Interests

Biomarkers; Cancer; Dietary factors; Genomics; Pancreas Cancer

Research Organizations

Medical Oncology: Subset Medical Oncology Faculty

Cancer Center: Cancer Prevention and Control

Research Summary

The prognosis for certain localized cancers, such as Stage II melanoma and Stage IA/IB non-small cell lung cancer is uncertain. Following curative-intent resection of the primary tumor, the long-term (5- or 10-year) overall survival for these patients can hover around 50%. At the same time, the morbidities associated with available adjuvant therapies precludes their use in the majority of these patients. Current prognostic models derived from conventional clinicopathologic parameters are insufficient to identify, at the time of diagnosis, the subset of patients at highest risk of recurrence for selective adjuvant therapy administration. The goal of my research program is to develop novel prognostic models for both early-stage non-small cell lung cancer and melanoma. Variables reflecting characteristics of the index tumor (somatic mutations, differential transcript profiling, differential protein expression), the patient's germline genetics as well as lifestyle behaviors are all simultaneously considered.

Specialized Terms: Molecular cancer epidemiology; Cancer prognosis; Melanoma; Skin cancer; Lung cancer; Pancreatic Neuroendocrine Tumors (PNETs); Tuberous Sclerosis Complex; Next generation sequencing; Somatic tumor mutations; Germline genetic variation; Immunohistochemistry-based biomarkers; Biospecimens and biobanking; Lifestyle choices associated with cancer outcome

Selected Publications

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Contact Info

Bonnie Elyssa Gould Rothberg, MD, PhD, MPH
Patient Care Location
St. Raphael's Adult Primary Care CenterOrchard Medical Center
330 Orchard Street, Ste 2nd Floor

New Haven, CT 06511
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Office Location
Sterling Hall of Medicine, I-Wing
333 Cedar Street, Ste SHM-I234E

New Haven, CT 06510
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Mailing Address
Yale Cancer Center
P.O. Box 208028

New Haven, CT 06520-8028