Trypanosomiasis/Tsetse Research

Tsetse Fly

The Aksoy lab studies multiple aspects of tsetse flies, the vectors of African trypanosomes. Trypanosomes are the causative agents of the devastating Sleeping Sickness disease in Sub-Saharan Africa. The lab’s work spans a range of projects including tsetse immunity, reproduction and symbiosis, tsetse-symbiont and trypanosome interactions, tsetse genomics and population genetics, and trypanosome developmental processes in tsetse. The ultimate goal of our work is to improve current control methods and/or develop novel strategies to reduce or eliminate the transmission of Sleeping Sickness in Sub-Saharan Africa.

Publications

  • Beadell JS, Hyseni C, Abila PP, Azabo R, Enyaru JC, Ouma JO, Mohammed YO, Okedi LM, Aksoy S, Caccone A: Phylogeography and population structure of Glossina fuscipes fuscipes in Uganda: implications for control of tsetse. PLoS Negl Trop Dis 2010, 4(3):e636.
  • Wang J, Wu Y, Yang G, Aksoy S: Interactions between mutualist Wigglesworthia and tsetse Peptidoglycan Recognition Protein (PGRP-LB) influence trypanosome transmission. Proc Natl Acad Sci USA 2009, in press.
  • Weiss BL, Wu Y, Schwank JJ, Tolwinski NS, Aksoy S: An insect symbiosis is influenced by bacterium-specific polymorphisms in outer-membrane protein A. Proc Natl Acad Sci USA 2008, 105(39):15088-15093.
  • Attardo GM, Lohs C, Heddi A, Alam UH, Yildirim S, Aksoy S: Analysis of milk gland structure and function in Glossina morsitans: Milk protein production, symbiont populations and fecundity. J Insect Physiol 2008, 54(8):1236-1242.
  • Attardo GM, Guz N, Strickler-Dinglasan P, Aksoy S: Molecular aspects of viviparous reproductive biology of the tsetse fly (Glossina morsitans morsitans): Regulation of yolk and milk gland protein synthesis. J Insect Physiol 2006, 52:1128-1136.
For complete list of publications and pdfs please see the Aksoy Lab website.