Translational Research in Malaria
Professor Parikh's research interests focus on translational studies of malaria in sub-Saharan Africa. Dr. Parikh focuses upon several aspects of malaria: early host immune responses to infection, human genetics, and treatment. Current projects include: (1) understanding host factors affecting response to artemisinin-based antimalarial therapies using a combination of individual and population-based pharmacologic approaches to inform treatment guidelines; 2) characterizing the impact of host genetic and transcriptional variability in early immune responses to malaria; and 3) understanding the impact of the HIV epidemic on the treatment of malaria in co-endemic regions.
Antimalarial Pharmacology and Pharmacodynamics in Uganda
An ongoing study in Tororo, Uganda aims to characterize the PK/PD and pharmacogenetics of antimalarials in the context of HIV co-infection, development and pregnancy. Additional studies aim to understand important interactions between the most widely used antiretrovirals and antimalarials.
Dynamic Malaria Modeling
Population-based modeling studies aim to understand the PK/PD of antimalarials used in treatment and prevention settings. Studies in conjunction with the Galvani group aim to understand the interaction between malaria and other infectious diseases.
Host Response to Malaria
Through use of next-generation sequencing, we are studying the host response to malaria and antimalarial treatment in the setting of HIV and pregnancy.