Translational Research in Malaria

Professor Parikh's research interests focus on translational studies of malaria in sub-Saharan Africa. Dr. Parikh focuses upon several aspects of malaria: early host immune responses to infection, human genetics, and treatment. Current projects include: (1) understanding host factors affecting response to artemisinin-based antimalarial therapies using a combination of individual and population-based pharmacologic approaches to inform treatment guidelines; 2) characterizing the impact of host genetic and transcriptional variability in early immune responses to malaria; and 3) understanding the impact of the HIV epidemic on the treatment of malaria in co-endemic regions.

Projects

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Antimalarial Pharmacology and Pharmacodynamics in Uganda

An ongoing study in Tororo, Uganda aims to characterize the PK/PD and pharmacogenetics of antimalarials in the context of HIV co-infection, development and pregnancy. Additional studies aim to understand important interactions between the most widely used antiretrovirals and antimalarials.

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Immunogenetics of Malaria Susceptibility

Innate Immune Responses in Populations with Differing Susceptibility to Malaria in Burkina Faso

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Dynamic Malaria Modeling

Population-based modeling studies aim to understand the PK/PD of antimalarials used in treatment and prevention settings. Studies in conjunction with the Galvani group aim to understand the interaction between malaria and other infectious diseases.

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Host Response to Malaria

Through use of next-generation sequencing, we are studying the host response to malaria and antimalarial treatment in the setting of HIV and pregnancy.