Asthma; Genetics; Sepsis
Professor DeWan seeks to understand how variation in the human genome contributes to complex human diseases. Using high-throughput technologies, he conducts genome-wide association studies to map disease susceptibility loci. His work also emphasizes the development of methods that improve the way in which this information is interpreted and utilized by disease researchers. He is also interested in the role that the interaction between genetic and environmental factors plays on disease susceptibility. His past work mapping disease genes has led to the discovery of susceptibility loci for age-related macular degeneration, non-syndromic hearing loss, renal function and myopia. Current projects include a genetic study of childhood asthma in collaboration with the Yale Center for Perinatal, Pediatric and Environmental Epidemiology, a study of genetic factors predisposing women to develop preeclampsia during pregnancy in collaboration with researchers at Brown and Yale Universities, and a study of genetic susceptibility loci for sepsis in collaboration with investigators at the Norwegian University of Science and Technology.
Extensive Research Description
Family-specific genetic variants contributing to asthma susceptibility: 1R01HL116742, NIH/NHLBI, DeWan (PI), 01/15/13-12/31/17
Identification of associations between genetic factors and asthma that are modified by obesity: FA8650-13-2-6371, USAF/AFMC, DeWan (PI), 02/08/13 – 02/07/15
Fetal Genetic Contributions to Preeclampsia: 1R21HD070177, NIH/NICHD, Triche/DeWan (co-PIs), 04/01/12-03/31/14
Genome-wide association studies in patients with bacterial sepsis ‘GWASEPSIS’: Liaison Committee between the Central Norway Regional Health Authority (RHA) and the Norwegian University of Science and Technology (NTNU), Damas (PI), 06/01/12 – 06/01/13
- DeWan AT, Egan KB, Hellenbrand K, Sorrentino K, Pizzoferrato N, Walsh KM, Bracken MB. Whole-exome sequencing of a pedigree segregating asthma. BMC Medical Genetics. 2012 Oct 9;13(1):95.
- Zhao L, Triche EW, Walsch KM, Bracken MB, Saftlas AF, Hoh J, DeWan AT. Genome-wide association study identifies a maternal copy-number deletion in PSG11 enriched among preeclampsia patients. BMC Pregnancy and Childbirth 2012. 12(1): 61.
- Murk W, Walsh K, Hsu L-I, Zhao L, Bracken M, DeWan A. Attempted replication of 50 reported asthma risk genes identifies SNPs in RAD50 and PTPRE as associated with childhood atopic asthma. Human Heredity 2011. 71(2):97-105. Epub 2011 Jul 6.
- DeWan A, Triche E, Xu X, Hsu L-I, Zhao C, Belanger K, et al. PDE11A associations with asthma: results of a genome-wide association scan. Journal of Allergy & Clinical Immunology; 2010 Oct; 126(4):871-873.
- Walsh K, Bracken MB, Murk WK, Hoh J, DeWan AT. Association between reduced copy-number at T-cell receptor gamma (TCR[gamma]) and childhood allergic asthma: A possible role for somatic mosaicism. Mutation Research/Fundamental and Molecular Mechanisms of Mu
- DeWan A, Bracken MB, Hoh J. Two genetic pathways for age-related macular degeneration. Curr Opin Genet Dev. 2007 Jun;17(3):228-33. Epub 2007 Apr 27.
- DeWan A, Liu M, Hartman S, Zhang SS, Liu DT, Zhao C, Tam PO, Chan WM, Lam DS, Snyder M, Barnstable C, Pang CP, Hoh J. HTRA1 promoter polymorphism in wet age-related macular degeneration. Science. 2006 Nov 10;314(5801):989-92. Epub 2006 Oct 19.