Shiyi Wang, MD, PhD

Assistant Professor of Epidemiology (Chronic Diseases)

Research Organizations

School of Public Health: Chronic Disease Epidemiology

Yale Cancer Center: Cancer Prevention and Control | COPPER Center

Research Summary

My research endeavor contributes to literature on outcomes research, focusing on breast cancer and end-of-life care. I am leading several breast cancer projects, including an evaluation of preoperative breast MRI, development of an individualized decision aid to help radiotherapy decision-making, and assessment of sentinel lymph node biopsy for patients with ductal carcinoma in situ. I am also working on cost-effectiveness analyses of chemotherapy and genetic profiling, which will facilitate value-based practice. Currently, I conduct research examining end-of-life care intensity, such as patterns of end-of-life care transitions and he associations between hospice use and end-of-life expenditures.

Selected Publications

  • Lannin DR, Wang SY. Are Small Breast Cancers Good Because They Are Small or Small Because They Are Good? N Engl J Med 2017 Jun 8;376(23):2286-91. PMID: 28591529
  • Wang SY, Aldridge MD, Gross CP, Canavan M, Cherlin E, Bradley EH. End-of-Life Care Transition Patterns among Medicare Beneficiaries. Journal of the American Geriatrics Society 2017 Apr 3. doi: 10.1111/jgs.14891. PMID: 28369785
  • Wang SY, Kelly G, Gross CP, Killelea BK, Mougalian S, Presley C, Fraenkel L, Evans SB. Information needs of older women with early stage breast cancer when making radiotherapy decisions. 2017 Int J Radiat Oncol Biol Phys in press
  • Wang SY, Hsu SH, Huang S, Soulos PR, Gross CP. Longer Hospice Stays Associated With Decreased End-Of-Life Spending For Patients In Regions With High Expenditures. Health Affairs 2017 Feb;36(2):328-336. PMID: 28167723
  • Pollack CE, Soulos PR, Herrin J, Xu X, Christakis NA, Forman HP, Yu JB, Killelea BK, Wang SY, Gross CP. The Impact of Social Contagion on Physician Adoption of Advanced Imaging Tests in Breast Cancer. 2016 J Natl Cancer Inst in press
  • Wang SY, Aldridge MD, Gross CP, Canavan M, Cherlin E, Johnson-Hurzeler R, Bradley EH. End of Life Care Intensity and Hospice Use Patterns: A Regional-Level Analysis. Med Care 2016 Jul;54(7):672-8. PMID: 27111747
  • Wang SY, Hsu SH, Gross CP, Sanft T, Davidoff AJ, Ma X, Yu JB. Association Between Time Since Cancer Diagnosis and Health-Related Quality of Life: A Population-Level Analysis. Value in Health 2016 Jul-Aug;19(5):631-8. PMID: 27565280
  • Wang SY, Aldridge MD, Gross CP, Canavan M, Cherlin E, Johnson-Hurzeler R, Bradley EH. End-of-Life Transitions among Hospice Enrollees. Journal of the American Geriatrics Society. 2016 Feb; 64(2):314-22. doi: 10.1111/jgs.13939. PMID: 26889841
  • Wang SY, Long JB, Killelea BK, Evans SB, Roberts KB, Silber A, Gross CP. Preoperative Breast Magnetic Resonance Imaging and Contralateral Breast Cancer Occurrence Among Older Women with Breast Cancer. J Clin Oncol. 2015 Nov 30. pii: JCO629741. [Epub ahead of print] PMID: 26628465
  • Killelea BK, Yang VQ, Wang SY, Plasilova M, Hayse B, Mougalian S, Chagpar A, Horowitz N, Pusztai L, Lannin DR. Racial differences in the use and outcome of neoadjuvant chemotherapy for breast cancer: Results from the National Cancer Database. J Clin Oncol. 2015 Nov 23. pii: JCO637801. [Epub ahead of print] PMID: 26598753
  • Wang SY, Wang R, Yu JB, Ma X, Xu X, Kim SP, Soulos PR, Saraf A, Gross CP. Understanding Regional Variation in Medicare Expenditures for Initial Episodes of Prostate Cancer Care. Med Care. 2014 Aug;52(8):680-7. PMID:25023913
  • Sen S, Wang SY, Soulos PR, Frick KD, Long JB, Roberts KB, Yu JB, Evans EB, Chagpar AB, Gross CP. Examining the cost-effectiveness of radiation therapy among older women with favorable-risk breast cancer. J Natl Cancer Inst 2014 Mar;106(3):dju008. doi: 10.1093/jnci/dju008. PMID: 24598714
  • Wang SY, Olson-Kellogg B, Shamliyan TA, Choi JY, Ramakrishnan R, Kane RL. Physical Therapy Interventions for Knee Pain Secondary to Osteoarthritis: A Systematic Review of Efficacy and Safety. Ann Intern Med. 2012 Nov 6;157(9):632-44. PMID: 23128863
  • Wang SY, Chu H, Shamliyan T, Jalal H, Kuntz KM, Kane RL, Virnig BA. Network meta-analysis of margin threshold for women with ductal carcinoma in situ receiving breast conserving surgery. J Natl Cancer Inst 2012 Apr 4;104(7):507-16. PMID:22440677
  • Wang SY, Shamliyan TA, Virnig BA, Kane RL. Tumor characteristics as predictors of local recurrence after treatment of ductal carcinoma in situ: A meta-analysis. Breast Cancer Research and Treatment 2011 May;127(1):1-14. PMID: 21327465
  • Wang SY, Kuntz KM, Tuttle TM, Kane R. Incorporating margin status information in treatment decisions for women with ductal carcinoma in situ: a decision analysis. Breast Cancer Research and Treatment 2010 Nov;124(2):393-402. PMID: 20848183

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Contact Info

Shiyi Wang, MD, PhD
Office Location
Laboratory of Epidemiology and Public Health (LEPH)
60 College Street, Ste 432

New Haven, CT 06510
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