Yale Journal of Biology & Medicine
Immunofluorescence analysis of the cerebral organoids after 30 days in vitro in serial cryosections showing neural tube-like substructures, composed of radially organized cells with apico-basal polarity, arranged around a central lumen. The radially arranged cells at the luminal (apical) surface express the proliferative marker Ki67 (red), and more mature neurons expressing βIIITUBULIN (green) are found more superficially (basally), reproducing the typical architecture of the developing mammalian cortex. Such cerebral organoids can be derived from patients with autism spectrum disorder and compared to cerebral organoids derived from unaffected controls. Image courtesy of Jessica Mariani of the Vaccarino Lab, Child Study Center, and Program in Neurodevelopment and Regeneration, Yale School of Medicine, New Haven, Connecticut.
The Yale Journal of Biology and Medicine is a PubMed-indexed, open access, quarterly journal edited by Yale medical, graduate, and professional students and peer reviewed by an extensive network of experts in the fields of biology and medicine. The journal aims to showcase outstanding research articles from all areas of biology and medicine, to publish significant case reviews, and to provide both perspectives on personal experiences in medicine and reviews of the current state of biology and medicine.
To all interested authors: Starting in June 2015, YJBM will devote entire issues to its focus topics. This means that all manuscripts in an issue will be related to the focus topic. As a result, we will not be considering off-topic manuscripts in the coming months. Please keep an eye out for our future focus topics, and thank you for your understanding.
Upcoming focus topics:
June 2015: Cancer
September 2015: Addiction
December 2015: Personalized Medicine and Genomics
March 2016: Neurodegenerative Diseases
Editor's Picks from the Current IssueVolume 88, Issue 1
Danielle Gerhard and Nicholas Vincent
Karthikeyan Ardhanareeswaran, Gianfilippo Coppola, and Flora Vaccarino
Russell G. Port, Ayesha R. Anwar, Matthew Ku, Gregory C. Carlson, Steven J. Siegel, and Timothy P.L. Roberts
Gerrit I. van Schalkwyk, Katherine Klingensmith, and Fred R. Volkmar