Yale Journal of Biology & Medicine

alt text

Immunofluorescence analysis of the cerebral organoids after 30 days in vitro in serial cryosections showing neural tube-like substructures, composed of radially organized cells with apico-basal polarity, arranged around a central lumen. The radially arranged cells at the luminal (apical) surface express the proliferative marker Ki67 (red), and more mature neurons expressing βIIITUBULIN (green) are found more superficially (basally), reproducing the typical architecture of the developing mammalian cortex. Such cerebral organoids can be derived from patients with autism spectrum disorder and compared to cerebral organoids derived from unaffected controls. Image courtesy of Jessica Mariani of the Vaccarino Lab, Child Study Center, and Program in Neurodevelopment and Regeneration, Yale School of Medicine, New Haven, Connecticut.

The Yale Journal of Biology and Medicine is a PubMed-indexed, open access, quarterly journal edited by Yale medical, graduate, and professional students and peer reviewed by an extensive network of experts in the fields of biology and medicine. The journal aims to showcase outstanding research articles from all areas of biology and medicine, to publish significant case reviews, and to provide both perspectives on personal experiences in medicine and reviews of the current state of biology and medicine.

To all interested authors: Starting in June 2015, YJBM will devote entire issues to its focus topics. This means that all manuscripts in an issue will be related to the focus topic. As a result, we will not be considering off-topic manuscripts in the coming months. Please keep an eye out for our future focus topics, and thank you for your understanding.

Upcoming focus topics:

June 2015: Cancer

September 2015: Addiction

December 2015: Personalized Medicine and Genomics

March 2016: Neurodegenerative Diseases

June 2016: Gender Health

September 2016: Microbiome

December 2016: Epigenetics

Editor's Picks from the Current Issue

Volume 88, Issue 1

Letter from the Editors

Danielle Gerhard and Nicholas Vincent

The Use of Stem Cells to Study Autism Spectrum Disorder

Karthikeyan Ardhanareeswaran, Gianfilippo Coppola, and Flora Vaccarino

Prospective MEG Biomarkers in ASD: Pre-Clinical Evidence and Clinical Promise of Electrophysiological Signatures

Russell G. Port, Ayesha R. Anwar, Matthew Ku, Gregory C. Carlson, Steven J. Siegel, and Timothy P.L. Roberts

Gender Identity and Autism Spectrum Disorders

Gerrit I. van Schalkwyk, Katherine Klingensmith, and Fred R. Volkmar