YCCI biomedical informatics activities are coordinated by the Yale Center for Medical Informatics (YCM), which offers a full range of consultation and support services to provide clinical researchers and their staff with the tools necessary to enter, maintain, and retrieve clinical research data.
YCMI services span the life cycle of the protocol from initial protocol review to final data analysis:
- Pre CRF design: Assistance with electronic implementation of the protocol. Assessment of what would be involved in electronically setting up the different aspects of data capture, for example, study calendar, study sites, users etc.
- CRF design: In conjunction with the PI, YCAS and the study coordinator, YCMI assists in defining the data elements involved in the protocol including data validation and integrity. This also involves grouping them into CRFs convenient for data capture.
- Data Monitoring: In collaboration with the PI and the study coordinator, YCMI generates reports that can be run on a regular basis to facilitate data monitoring.
- Data Retrieval: Assistance to study personnel in retrieval of data as and when required and also generation of reports for IRB submission.
Biomedical faculty from Yale Pathology informatics, YCMI and the Yale Cancer Center are working to expand the use of caTissue (an open-source component of NCI’s caBIG initiative) across the medical campus so that it can provide a standardized specimen-tracking tool to investigators that are currently maintaining their own specimen-banking operations.
YCMI and Yale’s Keck Biotechnology Laboratory support high-throughput genomic and proteomic research. Major initiatives include the Yale Microarray Database to store and analyze data from microarray studies of gene expression, the Yale Protein Expression Database to support mass spectrometry-based proteomics research, and the Yale High-Throughput Sequencing Database to support high-throughput sequencing studies. Many laboratories within Yale and at collaborating institutions, including other CTSA sites, use these three databases.
Researchers who would like informatics support should contact:
- Theresa Katz
Office of Research Services Coordinator