Diabetes Newsletter

Spring 2012

Both type 1 and type 2 diabetes can be treated and managed with healthy eating, physical activity, and taking medications such as insulin to control blood glucose levels. Yale is also conducting research to develop new treatments as well as prevent diabetes in those at risk.

Why Research Matters

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In 1979 Dr. Robert Sherwin and Dr. William Tamborlane developed the insulin pump to treat type 1 diabetes. Today it’s used by more than 350,000 patients. Without volunteers like the children and their families who were willing to participate in clinical research, this groundbreaking discovery would not have been possible.

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Tips for Controlling Diabetes

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When you take care of your diabetes, you’ll feel better. You’ll reduce your risk for problems with your kidneys, eyes, nerves, feet and legs, and teeth. You’ll also lower your risk for a heart attack or a stroke. Your doctor may prescribe medication, but you can also take care of your diabetes by being physically active and following a healthy meal plan.

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Research to Treat and Prevent Type 1 Diabetes

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When Hannah Rosenfield was diagnosed with Type 1 diabetes at age 10, her mother Amy immediately looked beyond the standard treatment for something that might benefit her daughter long term.

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Understanding the Root of Type 2 Diabetes

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Dr. Gerald Shulman is working to uncover what happens in cells that leads to insulin resistance, which is at the core of type 2 diabetes. His research is pointing to new drug targets as well as exercise and dietary strategies that may lead to the reversal of insulin resistance and the prevention of type 2 diabetes.

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Upcoming Diabetes Trial

A study comparing the effectiveness of three different classes of medications in patients already taking Metformin for Type 2 diabetes. Please check back in November for details.


Diabetes & Related Research Trials

10
A Phase II Trial to Examine the Effect of Subcutaneous Exenatide (Bydureon®) on Glucose Control in Patients With Type I Diabetes
Disease/Condition: Type 1 Diabetes
Principal Investigator: Kevan Herold
A Reinforcement Approach to Improve Diabetes Management - Randomized Trial
Disease/Condition: Type 1 Diabetes
Principal Investigator: William Tamborlane
Acceleration of Insulin Action by Hyaluronidase During Closed-Loop Therapy
Disease/Condition: Type 1 Diabetes
Principal Investigator: Eda Cengiz
Assessment of Intranasal Glucagon in Children and Adolescents With Type 1 Diabetes
Disease/Condition: Diabetes Mellitus, Type 1
Principal Investigator: Jennifer Sherr
CTLA-4 Ig (Abatacept) FOR PREVENTION OF ABNORMAL GLUCOSE TOLERANCE AND DIABETES IN RELATIVES AT-RISK FOR TYPE 1 DIABETES MELLITUS
Disease/Condition: Abnormal Glucose Tolerance | Type 1 Diabetes
Principal Investigator: Kevan Herold
Effect of a Medium Chain Triglyceride Supplemented Diet on Cognitive Function and Brain Activation in Type 1 Diabetes.
Disease/Condition: Hypo-unawareness | Type 1 Diabetes
Principal Investigator: Robert Sherwin
Effect of Formoterol on the Counterregulatory Hormonal Response to Hypoglycemia in Type 1 Diabetes.
Disease/Condition: Type 1 Diabetes
Principal Investigator: Robert Sherwin
Effect of the Liraglutide on Automated Closed-Loop Glucose Control in Type 1 Diabetes
Disease/Condition: Type 1 Diabetes
Principal Investigator: Jennifer Sherr
Efficacy and Safety of Intranasal Glucagon for Treatment of Insulin Induced Hypoglycemia in Adults with Diabetes
Disease/Condition: Diabetes Mellitus, Type 1 | Diabetes Mellitus, Type 2
Principal Investigator: Jennifer Sherr
Glycemic Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE Study)
Disease/Condition: Diabetes Mellitus Type 2
Principal Investigator: William Tamborlane
Investigation Into Effects Upon Counterregulatory Responses to Hypoglycemia During Intensive Treatment of T1DM
Disease/Condition: Hypoglycemia | Type 1 Diabetes
Principal Investigator: Robert Sherwin
Metformin Therapy for Overweight Adolescents With Type 1 Diabetes
Disease/Condition: Diabetes Mellitus, Type 1
Principal Investigator: Eda Cengiz
Multi-Center, Prospective, Observational Study of the TS (Threshold Suspend) Feature with a Sensor-Augmented Pump System in Pediatric Patients with Type 1 Diabetes (CEP287)
Disease/Condition: Type 1 Diabetes
Principal Investigator: Jennifer Sherr
Natural History Study of the Development of Type 1 Diabetes
Disease/Condition: Diabetes Mellitus, Type 1
Principal Investigator: Kevan Herold
Neural Functioning of Feeding Centers in Obese Youth
Disease/Condition: Insulin Resistance | Obesity
Principal Investigator: Sonia Caprio
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
Disease/Condition: Diabetes Mellitus, Type 1
Principal Investigator: Kevan Herold
Pharmacokinetic Study of CYCLOSET ® 0.8 mg Tablets in Children and Adolescent Type 2 Diabetes Mellitus Subjects
Disease/Condition: Type 2 Diabetes
Principal Investigator: William Tamborlane
Prevalence of Carbohydrate Intolerance in Lean and Obese Children
Disease/Condition: Acanthosis Nigricans | Diabetes | Glucose Intolerance | Obesity
Principal Investigator: Sonia Caprio
RISE Pediatric Medication Study
Disease/Condition: Prediabetes | Type 2 Diabetes
Principal Investigator: Sonia Caprio
SONAR: Study of Diabetic Nephropathy with Atrasentan A Randomized, Multicountry, Multicenter, Double-Blind, Parallel, Placebo-Controlled Study of the Effects of Atrasentan on Renal Outcomes in Subjects with Type 2 Diabetes and Nephropathy
Disease/Condition: Diabetic Nephropathy
Principal Investigator: Neera Dahl
Study to Investigate Benefits of Weight Loss in Young Adults and Adolescents
Disease/Condition: Insulin Resistance | Obesity
Principal Investigator: Romy Kursawe
Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
Disease/Condition: Beta-cell Function | Childhood Obesity | Impaired Glucose Tolerance | Insulin Resistance | Metabolic Syndrome | Pre-Diabetes
Principal Investigator: Sonia Caprio
Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk"
Disease/Condition: Autoantibody Positive | High Risk | Impaired Glucose Tolerance | Non-diabetic Relatives at Risk for Type 1 Diabetes
Principal Investigator: Kevan Herold
The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
Disease/Condition: Brown Adipose Tissue
Principal Investigator: Robert Sherwin
TODAY Genetics Study
Disease/Condition: Type 2 Diabetes
Principal Investigator: Sonia Caprio
Warming up to sensors: Does site warming improve continuous glucose monitor performance?
Disease/Condition: Type 1 Diabetes