About the Dean's Workshops
The Dean's Workshops series brings together physicians and scientists from across the School of Medicine, the Yale medical center and Yale University to address topics of critical importance in advancing biomedical research and patient care.
The workshops serve as a forum for new ideas and collaborations across disciplines.
Imaging the Brain at Work: Quantitative Neuroscience with Magnetic Resonance
Friday, September 23, 2011, 1:00 - 3:00 pm
The Anylan Center Auditorium, N143
300 Cedar St., New Haven
Contact Information
Website: http://qnmr.yale.eduEmail: qnmr@yale.edu
Phone: 203-785-6205
PDF Flyer
Magnetic resonance imaging and spectroscopy (MRI, MRS) allow non-invasive 3D imaging of the brain’s structure and function. These magnetic resonance methods play an increasingly important role in quantitative neuroscience studies, addressing fundamental issues in normal activity as well as pathophysiology. In combination with methods such as optical imaging and electrophysiology, MRI and MRS methods allow true multi-modal imaging of the brain at work. Because magnetic resonance is non-invasive, methods and insights developed in animal models can be directly translated to human studies. This Dean’s Workshop will feature several examples of how the working brain can be imaged by magnetic resonance in a variety of animal models and demonstrate how resources may be accessed to conduct new research initiatives in quantitative neuroscience with magnetic resonance.
| Introduction | ||
| Carolyn W. Slayman, Ph.D.
Deputy Dean for Academic and Scientific Affairs Sterling Professor of Genetics Professor of Cellular and Molecular Physiology | ||
| Opening Remarks | ||
| Douglas L. Rothman, Ph.D.
Professor of Diagnostic Radiology & Biomedical Engineering Co-Director of MRRC | ||
| Presentations | ||
| Brain Function with Multi-Modal MRI
D. S. Fahmeed Hyder, Ph.D. Professor of Diagnostic Radiology & Biomedical Engineering Director of QNMR Core Center | ||
Neurochemistry with Multi-Nuclear MRS
| ||
| MRS Insights into the Pathophysiology of Mood Disorders
Gerard Sanacora, M.D., Ph.D. Professor of Psychiatry Director of Depression Research Program | ||
| Functional MRI of Cell Migration
Erik M. Shapiro, Ph.D. Assistant Professor of Diagnostic Radiology & Biomedical Engineering | ||
Neuroimaging of Impaired Consciousness in Epilepsy | ||
| Closing Remarks | ||
| Douglas L. Rothman, Ph.D.
Professor of Diagnostic Radiology & Biomedical Engineering Co-Director of MRRC | ||
Refreshments will be served during a Poster Session immediately after the workshop.
Sponsored by
Office of the Dean, Yale School of Medicine
Construction and Characterization of Genetically Engineered Mice
Friday, November 12, 2010, 1:30 - 3:30 pm
The Anylan Center Auditorium
300 Cedar St., New Haven
The ability to manipulate the mouse genome has revolutionized biology. The effects of genetic manipulation on mouse physiology and morphology allow us a more complete understanding of gene function in the whole animal. The Yale Animal Genomics Service offers a wide variety of genetic techniques to develop mice uniquely suited to individual research questions. In addition, technical and collaborative resources to assess altered phenotypes in genetically altered mice are available through the Yale Mouse Research Pathology Core. Join us for this Dean’s Workshop to hear how these Yale core resources design and characterize mouse models of human disease.
Contact Information
Yale Animal Genomics Services: http://ags.med.yale.edu/
Yale Mouse Research Pathology: http://www.mrp.yale.edu/
| Introduction | ||
| Carolyn W. Slayman, Ph.D.
Deputy Dean for Academic and Scientific Affairs Sterling Professor of Genetics Professor of Cellular and Molecular Physiology | ||
| Opening Remarks | ||
| Timothy P. Nottoli, Ph.D.
Research Scientist in Comparative Medicine | ||
| Presentations | ||
| 1:35 pm
| Making Mice: Transgenics and Knockouts | |
| 1:45 pm
| Cryopreservation and In Vitro Fertilization James M. McGrath, M.D., Ph.D. Research Scientist in Comparative Medicine, Genetics, & Pediatrics | |
| 2:00 pm
| What’s Wrong with My Mouse? Phenotypic Characterization of GEM Caroline J. Zeiss, B.V. S.c., Dip. AVCP, Ph.D. Associate Professor, Comparative Medicine and Ophthalmology | |
| 2:20 pm
| Beyond the Macrophage: An Improved Mouse Model of Gaucher’s Disease | |
| 2:40 pm
| The Quest for a Mouse Model of Syphilis Dana Dunne, Ph.D. Assistant Professor of Internal Medicine | |
| 3:10 pm
| Genetic Analysis of Context-Dependent Cell Signaling by FGF Receptors V.P. Eswarakumar, M.Sc., Ph.D. Assistant Professor of Orthopaedics, and Pharmacology | |
Refreshments will be served
Sponsored by
Office of the Dean, Yale School of Medicine
Nanotechnologies in Medical Research
Friday, September 17, 2010, 1:30 - 3:30 pm
The Anylan Center Auditorium
300 Cedar St., New Haven
Recent advances in fabrication and characterization of materials and devices at the nanoscale are contributing to medical research in drug delivery, pathogen detection, cell separation methods, DNA sequencing, immunotherapy, and more. Nanotechnology facilities on the Yale campus and their application in Yale School of Medicine research will be the focus of this Dean’s Workshop.
Nanotechnology Facilities
- nanoscale artificial structures, templates, and devices
- images and chemistry of materials and devices
- scanning microscopy of surfaces
Microfluidics
- cell separation methods
- inflammation diagnostics
Nanoparticles for Therapy
- targeted drug delivery
- antigen delivery
Nonlinear Biophotonics
- fluorescence correlation microscopy
- single molecule fluorescence
| Introduction | ||
| Carolyn W. Slayman, Ph.D.
Deputy Dean for Academic and Scientific Affairs Sterling Professor of Genetics Professor of Cellular and Molecular Physiology | ||
| Opening Remarks | ||
| Paul A. Fleury, Ph.D.
Frederick W. Beinecke Professor of Engineering & Applied Physics Professor of Physics | ||
| Presentations | ||
| Yale Facilities for Microscopy and Nanofabrication
Michael Rooks, Ph.D. Senior Research Scientist Associate Director of Research Facilities, Yale Institute for Nanoscience and Quantum Engineering | ||
Degradable Polymer Nanoparticles for Treatment of Cancer
| ||
| Tiny Solutions to Big Problems: Seeing and Controlling Immunity With Nanotechnology
Tarek Fahmy, Ph.D. Associate Professor of Biomedical Engineering & Chemical Engineering | ||
| High-throughput Manipulation, Sorting and Separation of Cells via Ferro-microfluidics
Hur Koser, Ph.D. Associate Professor of Electrical Engineering | ||
Single Cell Microfluidics for Systems Oncology | ||
| Biophotonic Measurement of Multimerization for von Willibrand Disease
Michael Levene, Ph.D. Associate Professor of Biomedical Engineering | ||
Refreshments will be served
Sponsored by
Office of the Dean, Yale School of Medicine
Next Generation Genomics: The impact of high throughput DNA sequencing on genetic research
Friday, May 21, 2010, 1:30 - 3:30 pm
The Anylan Center Auditorium
300 Cedar St., New Haven
Recent inventions of genomic technologies are a major driving force for new discoveries in biology and biomedical research which have reshaped our understanding of how the genome functions. High-throughput DNA sequencing and other cutting-edge genomic technologies available through the Yale Center for Genome Analysis and their positive impact on research at Yale University will be the focus of this Dean’s Workshop at the School of Medicine.
| Opening Remarks | |
| Carolyn W. Slayman, Ph.D.
Deputy Dean for Academic and Scientific Affairs Sterling Professor of Genetics Professor of Cellular and Molecular Physiology | |
| Presentations | |
| The Continuing Revolution in Genomics: Next-Generation
DNA Sequencing and its Impact on Biomedical Research Richard P. Lifton, M.D., Ph.D. Chair, Department of Genetics Sterling Professor of Genetics | |
Overview of Yale Center for Genome Analysis and Available Technologies
| |
| The Impact of Next-Generation Genomics from Genome-Wide Association to Whole Exome Sequencing: From 20,072 to 1 Murat Gunel, M.D. Professor of Neurosurgery | |
| Using Next-Generation Sequencing to Study Gene Regulation in Primate and Mouse Development James Noonan, Ph.D. Assistant Professor of Genetics | |
Uncovering Novel Processing Pathways for Small Regulatory RNAs Using Illumina High-Throughput Sequencing | |
| Closing Remarks | |
Refreshments will be served
Sponsored by
Office of the Dean, Yale School of Medicine
Proteomics: Discovery to Validation
Friday, October 17, 2008, 1:30–3:30 pm
The Anlyan Center Auditorium
300 Cedar Street, New Haven
The complete sequencing of the human genome, and many other genomes has given rise to the field of proteomics, which seeks to extend genomic discoveries to the level of the corresponding proteins. New technologies are being rapidly developed to quantify the concentrations of individual proteins, along with their many post-translational modifications in vivo, and also to identify differentially expressed biomarker proteins that may enable the earlier diagnosis, improved prognosis, and more “personalized” treatment of disease. This workshop will highlight the impact of proteomics on biomedical research covering a range of disease applications from hypertension to drug addiction and to the effect of bioterrorism and infectious disease agents. The workshop will also describe the state-ofthe- art proteomics technologies available at Yale’s W.M. Keck Foundation Biotechnology Resource Laboratory and its associated centers.
Website: http://keck.med.yale.edu/
Tours of the Keck Proteomics facilities located at 300 George Street will be available immediately following the workshop. Sign-up sheets will be available in the lobby.
Opening Remarks | |
Carolyn W. Slayman, Ph.D.
| |
Presentations | |
Proteomics at the Keck Laboratory
| |
New Mechanisms Controlling Cell Volume, Neuronal Excitability, and Blood Pressure Revealed via Quantitative Proteomic
| |
Approaches and Challenges in Neuroproteomics
| |
Knowledge of the Influenza Virion Proteome Provides Insight into Virus-Host Interactions
| |
| Closing Remarks | |
Erol E. Gulcicek, PhD
|
Refreshments will be served.
Sponsored by
Office of the Dean, Yale School of Medicine
Unlocking the Genome to Personalized Medicine
New Fronties in Genomic Technologies at the Keck Laboratory
Friday September 12, 2008, 1:30- 3:30 pm
The Anlyan Center Auditorium
300 Cedar Street, New Haven
Cutting-edge genomic technologies available through the Keck Biotechnology Resource Laboratory and their positive impact on research at Yale University will be the focus of the next Dean’s Workshop at the School of Medicine. Come and hear researchers describe the impressive capabilities of microarray, next-generation DNA sequencing, and other genomic technologies and their role in reshaping our understanding of how the human genome functions.
Keck Lab Contact Information
Website: http://keck.med.yale.edu/microarrays/
Email: microarrays@yale.edu
Tours of the Keck Genomic facilities located at 300 George Street will be available immediately following the workshop. Sign-up sheets will be available in the lobby.
| Opening Remarks | |
Robert J. Alpern, MD
| |
| Presentations | |
Current Genomic Technologies at Keck Richard P. Lifton, MD, PhD
| |
Overview of Currently Available Genomic Technologies at Keck Shrikant M. Mane, PhD
| |
Microarray Analysis and Clinical Trial For Skin Cancer Prevention Allen E. Bale, MD
| |
Identification of Susceptibility Loci for Intracranial Aneurysms Using Genome-wide Association Studies Murat Gunel, MD
| |
Gene Expression in the Developing Cortex Using a Genome Analyzer James Noonan, PhD
| |
| Closing Remarks | |
Shrikant M. Mane, PhD | |
REFRESHMENTS WILL BE SERVED
SPONSORED BY
Office of the Dean, Yale School of Medicine
A Window into the Body
Molecular Imaging with Positron Emission Tomography
Friday November 30, 2007 1:30-3:30PM
The Anlyan Center Auditorium
300 Cedar Street, New Haven
Molecular imaging research at Yale has taken a major leap forward with the opening of the Positron Emission Tomography Center. Come and hear scientists describe the impressive capabilities of the new, state-of-the-art Yale PET Center and its research vision for the future. Learn about the unique role PET imaging is playing in research areas such as post-traumatic stress disorder, neurodegenerative disease, and schizophrenia. Website: http://petcenter.yale.edu
| Opening Remarks | |
Robert J. Alpern, MD
| |
| Presentations | |
Positron Emission Tomography: The Yale Experience Richard E. Carson, PhD
| |
PET Imaging Agent Development: A Tango of Chemistry and Biology Henry Yiyan Huang, PhD
| |
Translational Applications of Molecular Imaging with PET Yu-Shin Ding, PhD
| |
Trauma, PTSD and Resilience: Insights from PET Imaging Alexander Neumeister, MD
| |
Functional Imaging in the Nonhuman Primate: Cerebral Metabolic Markers to Assess Novel Cognitive Enhancers Stacy Castner, PhD
| |
PET Imaging: A Tool for Viewing Axon Regeneration Stephen Strittmatter, MD, PhD
| |
REFRESHMENTS WILL BE SERVED
SPONSORED BY
Office of the Dean, Yale School of Medicine
Panning for Gold
High-Throughput Screening of Small Molecules at Yale
Friday November 10, 2006 1:30 - 3:30 PM
The Anlyan Center Auditorium
300 Cedar Street, New Haven
Small molecules can serve as valuable research tools and aid in the discovery of new therapeutics. They can mimic or disrupt cellular interactions, enzymatic activities and signaling pathways critical in development and disease. The Yale Chemical Genomics Screening Facility identifies small molecules with a desired biological activity by testing thousands of small molecule compounds individually in high-throughput biological assays. Hear Yale scientists describe their search for small molecules that regulate the activity of RNA riboswitches, facilitate neural repair, stop the cellular aging process and alter zebrafish development.
| Opening Remarks | |
Opening Remarks Robert J. Alpern, MD
| |
| Presentations | |
Small Molecule Screening in Academia Craig M. Crews, PhD
| |
Finding Active Small Molecules Through Yale’s Chemical Genomics Center Janie Merkel, PhD
| |
High-Throughput Screening to Discover Small Molecule Promoters of Neurite Outgrowth Erik C. Gunther, PhD
| |
Combining Chemical and Mendelian Genetics to Study Zebrafish Development Scott A. Holley, PhD
| |
High-Throughput Screening for the Discovery of Riboswitch-Targeting Antibacterial Compounds Kenneth F. Blount, PhD
| |
Cell-based Screening for Inhibitors of Cellular Senescence Daniel C. DiMaio, MD, PhD
| |
REFRESHMENTS WILL BE SERVED
SPONSORED BY
Office of the Dean, Yale School of Medicine
Sorting it All Out
New Directions in Flow Cytometry
Friday April 28, 2006 1:00 - 3:00 PM
The Anlyan Center Auditorium
300 Cedar Street, New Haven
Using the high-speed sorters, fluorescent tags and color analyzers of flow cytometry, biologists can count, sort and characterize the function of each of the millions of cells in a sample—at a rate as high as 30,000 cells per second. Flow cytometry has been a mainstay of immunology research since it was first introduced in the 1970s, but with recent advances in photonics, tagging and computational horsepower, the technique is making inroads into many other fields, including stem cell biology and cancer research. New refinements are allowing scientists to precisely quantify and characterize cell-cycle phase, cell proliferation, calcium signaling and intracellular molecular interactions.
| Opening Remarks | |
Robert J. Alpern, MD
| |
| Presentations | |
Flow Cytometry at Yale: Many Things to Many People Mark J. Shlomchik, MD, PhD
| |
Investigating Human T Cells Using Multicolor Flow Cytometry Insoo Kang, MD
| |
Flow Cytometric Analysis of FRET to Study the Interaction Between CFP- and YFP-Tagged Proteins David Stepensky, PhD
| |
Use of FACS in the Isolation and Characterization of Gastrointestinal Neuroendocrine Cells Mark S. Kidd, PhD
| |
Employing the Power of Multicolor Flow Cytometry in Identifying Dendritic Cell Subsets That Initiate Antiviral Immunity Akiko Iwasaki, PhD
| |
Functional Analysis of Ionic Flux in Isolated Endosomes Using Flow Cytometry Michael Carrithers, MD, PhD
| |
SPONSORED BY
Office of the Dean, Yale School of Medicine
Mending the Human Machine
Biomedical Engineering at Yale
Friday February 24, 2006 1:30 - 3:30 PM
The Anlyan Center Auditorium
300 Cedar Street, New Haven
Biomedical Engineering, one of Yale’s youngest and most dynamic departments, stands at the center of diverse research partnerships that are combining insights from engineering, basic biology and the clinic to bring novel treatments to the bedside. Hear Yale scientists describe innovative vaccine strategies, the application of state-of-the-art microscopy in the clinic, and techniques for guiding stem cells to build new blood vessels and nerves.
| Opening Remarks | |
Carolyn W. Slayman, PhD
| |
| Presentations | |
BIOMEDICAL ENGINEERING AT YALE:
W. Mark Saltzman, PhD
| |
TOWARDS THE CONSTRUCTION OF NEW GENERATION VACCINE SYSTEMS BASED ON BIOLOGICAL-DRIVEN DESIGNS Tarek Fahmy, PhD
Ira S. Mellman, PhD
| |
BRINGING MULTIPHOTON MICROSCOPY TO THE CLINIC: ASSESSMENT OF WOUND HEALING WITH ARTIFICIAL SKIN GRAFTS AND OTHER APPLICATIONS Michael J. Levene, PhD
Jordan S. Pober, MD, PhD
| |
ARCHITECTURAL HYDROGELS: SCAFFOLDS FOR VASCULAR AND NEURAL PROGENITOR CELL CONSTRUCTS FOR THE NERVOUS SYSTEM Erin Lavik, ScD
Joseph A. Madri, MD, PhD
| |
REFRESHMENTS WILL BE SERVED
SPONSORED BY
Office of the Dean, Yale School of Medicine
Electron Microscopy in the Molecular Era
A World Inside the World You See
Friday November 4, 2005 1:30 - 3:30 PM
The Anlyan Center Auditorium
300 Cedar Street, New Haven
Given the remarkable progress in the fields of molecular biology and genome sequencing, there is a greater need than ever for high-resolution imaging techniques such as electron microscopy to study the sub-cellular localization and function of the thousands of new proteins that have been identified.
| Opening Remarks | |
Robert J. Alpern, M.D.
| |
| Presentations | |
General Overview Ira S. Mellman, PhD
Marc Pypaert, PhD
| |
From Golgi Vesicles to Golgi Stacks Graham B. Warrn, PhD
| |
Endocytic Mechanisms at the Neuronal Synapse Pietro De Camilli, MD
| |
Mitochondrial Dysfunction and Type 2 Diabetes Gerald I. Shulman, MD, PhD
| |
Imaging Macromolecules in their Cellular Context John Heuser, MD
| |
Tour A brief tour of the Electron Microscopy facility will follow | |
REFRESHMENTS WILL BE SERVED
SPONSORED BY Office of the Dean, Yale School of Medicine
Cool Science
Cryoelectron Microscopy and Structural Biology at the Near-Atomic Scale
Friday June 10, 2005 1:30 - 3:30 PM
The Anlyan Center Auditorium
300 Cedar Street, New Haven
Combining supercooled samples with computational muscle, cryoEM is providing an unprecedented window on cell structure. See Yale scientists' stunningly detailed pictures of the "molecular machines" of structural biology and learn how cryoEM is being used in a variety of studies.
| Opening Remarks | |
Robert J. Alpern, MD
| |
| Presentations | |
Molecular Microscopy - Past and Present Overview Vinzenz M. Unger, PhD
| |
Electron Crystallographic Studies of Copper Transport Stephen G. Aller
| |
Protein Structures Without Crystals: Single-particle Cryoelectron Microscopy Frederick J. Sigworth, PhD
| |
What the CryoEM Structure of the InsP3 Receptor Can Tell Us About Intracellular Calcium Signaling Barbara E. Ehrlich, PhD
| |
Structure and Dynamics of Type III Secretion Needle Complex Jorge E Galan, PhD, DVM
| |
REFRESHMENTS WILL BE SERVED
SPONSORED BY
Office of the Dean, Yale School of Medicine
General Clinical Research Center
A Resource for Clinical Investigation
FRIDAY MARCH 11, 2005 2:00 - 4:00 PM
The Anlyan Center Auditorium
300 Cedar Street, New Haven
| Opening Remarks | |
Robert J. Alpern, MD
| |
The New GCRC: A Resource for Clinical Investigation Robert S. Sherwin, MD
Barbara I. Gulanski, MD, MPH
| |
Training and Education on the GCRC: Future Directions Harlan M. Krumholz, MD
| |
Scientific Presentations of GCRC Investigators | |
Karl Insogna, MD
| |
Indomethacin, Gender and the Developing Brain Laura R. Ment, MD
| |
Cortical GABA and the Recovery from Alcohol Dependence John H. Krystal, MD Professor of Psychiatry Deputy Chair for Research, Psychiatry | |
SPONSORED BY
Office of the Dean, Yale School of Medicine




