Recently Funded Studies
Women’s Health Research at Yale supports new research that is expected to advance scientific knowledge and to improve women’s health. This year’s content areas include breast cancer, the second leading cause of cancer mortality among women; and obesity, which in women leads to higher rates of serious secondary health problems including diabetes and heart disease.
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The 2011 WHRY Pilot Project Program grants and recipients:
Anthony Koleske, Ph.D.
Anthony Koleske, Ph.D.
Targeting a Breast Cancer Invasion Control Switch
PI: Anthony J. Koleske, Ph.D., Professor of Molecular Biophysics and Biochemistry and Neurobiology
PI: Anthony J. Koleske, Ph.D., Professor of Molecular Biophysics and Biochemistry and Neurobiology
Co-PI: Titus J. Boggon, Ph.D., Assistant Professor of Pharmacology
These collaborators will take initial steps toward developing medications to treat metastasis, the spread of breast cancer; metastasis is the primary cause of death from this disease. The interdisciplinary team plans to identify small molecule compounds that disrupt the interaction of three proteins which form a "control switch" in breast cancer cells. The Yale Cancer Center has joined Women's Health Research at Yale in co-funding this study.
Matthew Rodeheffer, Ph.D.
Matthew Rodeheffer, Ph.D.
Mechanisms of Fat Mass Regulation in Females
PI: Matthew S. Rodeheffer, Ph.D., Assistant Professor of Comparative Medicine and of Molecular, Cellular and Developmental Biology
PI: Matthew S. Rodeheffer, Ph.D., Assistant Professor of Comparative Medicine and of Molecular, Cellular and Developmental Biology
Dr. Rodeheffer's study is designed to understand the cell mechanisms that control white adipose tissue mass in women at the onset of diet-induced obesity. Determining these mechanisms is highly relevant to everyone's health, but particularly important to women because they suffer greater obesity-related health consequences, including diabetes and heart disease.
