Bone Health

Finding the Mechanisms in Post-Menopausal Women that Maintain Bone

Angela Bruzzaniti, Ph.D.

Angela Bruzzaniti, Ph.D., Associate Research Scientist in Orthopaedics & Rehabilitation

Bone density is maintained through the coordinated actions of specialized bone cells that break down bone (osteoclasts) and build bone (osteoblasts). Postmenopausal osteoporosis, which is largely due to an increase in the activity of osteoclasts, is a major healthcare concern for older women. Dr. Angela Bruzzaniti’s research examined the mechanisms by which osteoclasts migrate, attach and break down bone, in order to develop osteoporosis therapies that interrupt this process.

Highlighted Study Findings

Dr. Bruzzaniti took crucial steps toward identifying and understanding the effects of the interactions of specific enzymes and proteins on bone resorption, the process by which osteoclasts break down, and bones are degraded. Understanding this process through study of these interactions continues to aid in the development of interventions that can manage or treat bone loss. These findings aided in more recent discoveries that illuminated the processes by which bone loss could be ameliorated.

Pilot Project Study was funded in 2002, Dr. Bruzzaniti is now at Indiana University.