Clinical Trials

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Active Cancer Trials Example

10
19F-MRS (Magnetic Resonance Spectroscopy) Studies of in-vivo 5-Fluorouracil Pharmacokinetics with and without Bevacizumab in Patients with Liver Metastases from Adenocarcinoma of the Colon
Disease/Condition: Colon | Colon Cancer
Principal Investigator: Howard Hochster
3-D Imaging Assessment of Scar Formation and Would Healing in Fat Grafted vs Non-Fat Grafted Facial Reconstruction Wound Sites
Disease/Condition: Autologous Fat Grafting | Scar Formation
Principal Investigator: Derek Steinbacher
A Comparison of the Blom Low Profile Voice Inner Cannula and the Passy-Muir One-Way Tracheotomy Tube Speaking Valve on Voice Production, Speech Intelligibility, and Biomechanical Swallowing Behavior
Disease/Condition: Mechanical Complication of Tracheotomy
Principal Investigator: Steven Leder
A Multi-arm Phase I Safety Study of Nivolumab in Combination with Gemcitabine/Cisplatin, Pemetrexed/Cisplatin, Carboplatin/Paclitaxel, Bevacizumab Maintenance, Erlotinib, Ipilimumab or as Monotherapy in Subjects with Stage IIIB/IV Non-small Cell Lung Cancer
Disease/Condition: Lung
Principal Investigator: Scott Gettinger
A Multi-center pilot study of the effect of Sorafenib on Portal Pressure in Patients with Cirrhosis, Significant Portal Hypertension and Hepatocellular Carcinoma
Disease/Condition: Hepatocellular Carcinoma | Liver
Principal Investigator: Guadalupe Garcia-Tsao
A Phase 1 Dose Escalation Study of BMS-982470 (Recombinant Interleukin-21, rIL-21) in Combination with BMS-936558 (Anti-PD-1) in Subjects with Advanced or Metastatic Solid Tumors
Disease/Condition: Melanoma, skin
Principal Investigator: Mario Sznol
A Phase 1/2 Study of the Oral ALK/EGFR Inhibitor AP26113
Disease/Condition: Advanced Malignancies | Anaplastic Large Cell Lymphoma | Carcinoma, Non-Small-Cell Lung | Diffuse Large Cell Lymphoma | Inflammatory Myofibroblastic Tumors
A Phase 1/2 Study of the Oral ALK/EGFR Inhibitor AP26113
Disease/Condition: Anus | Bladder | Bones and Joints | Brain and Nervous System | Breast - Female | Breast - Male | Cervix Uteri | Colon | Corpus Uteri | Esophagus | Eye and Orbit | Hodgkin's Lymphoma | Ill-Defined Sites | Kidney | Larynx | Lip, Oral Cavity and Pharynx | Liver | Lung | Lung Cancer | Melanoma, skin | Multiple Myeloma | Non-Hodgkin's Lymphoma | Other Digestive Organ | Other Endocrine System | Other Female Genital | Other Male Genital | Other Urinary | Ovary | Pancreas | Prostate | Rectum | Small Intestine | Soft Tissue | Stomach | Thyroid
Principal Investigator: Scott Gettinger
A Phase 1-2, Dose Escalation, Multicenter Study of Two Subcutaneous Regimens of SGI-110, a DNA Hypomethylating Agent, in Subjects with Intermediate or High-Risk Myelodysplastic Syndromes (MDS) or Acute Myelogenous Leukemia (AML)
Disease/Condition: Leukemia, not otherwise specified | Myeloid and Monocytic Leukemia
Principal Investigator: Nikolai Podoltsev
A Phase 1b Open-label Study to Evaluate the Safety and Tolerability of MEDI4736 in Combination with Tremelimumab in Subjects With Advanced Non-Small Cell Lung Cancer
Disease/Condition: Lung
Principal Investigator: Sarah Goldberg
A Phase 2 Study to See if Simtuzumab (GS-6624) is Safe and Works in Idiopathic Pulmonary Fibrosis (IPF)
Disease/Condition: Idiopathic Pulmonary Fibrosis
Principal Investigator: Danielle Antin-Ozerkis
A Phase I Dose Escalation Open-Label Safety, Pharmacokinetic and Pharmacodynamic Study to Determine the Recommended Phase II Dose of GSK1120212 Dosed in Combination with GSK2141795
Disease/Condition: Melanoma, skin
Principal Investigator: Joseph Paul Eder
A Phase I Dose Escalation Study Evaluating the Safety and Tolerability of GDC-0032 in Patients With Locally Advanced or Metastatic Solid Tumors And in Combination With Endocrine Therapy in Patients With Locally Advanced or Metastatic Hormone Receptor-Positive Breast Cancer
Disease/Condition: Anus | Bladder | Breast - Female | Breast - Male | Cervix Uteri | Colon | Esophagus | Kidney | Larynx | Liver | Lung | Other Digestive Organ | Other Endocrine System | Other Female Genital | Other Male Genital | Other Respiratory and Intrathoracic Organs
Principal Investigator: Lajos Pusztai
A Phase I Open label, Dose Finding Study of IMCgp100 in Patients with Advanced Malignant Melanoma
Disease/Condition: Melanoma, skin
Principal Investigator: Mario Sznol
A Phase I, Open-label, dose-escalation study of the safety and pharmacokinetics of MPDL3280A administered intravenously as a single agent to patients with locally advanced or metastatic solid tumors or hematologic malignancies
Disease/Condition: Bladder | Breast - Female | Colon | Esophagus | Kidney | Larynx | Lip, Oral Cavity and Pharynx | Lung | Melanoma, skin | Multiple Myeloma | Non-Hodgkin's Lymphoma | Other Digestive Organ | Other Male Genital | Pancreas | Prostate | Rectum | Soft Tissue | Stomach | Thyroid
Principal Investigator: Roy Herbst
A Phase I/II Study of A-dmDT390-bisFv (UCHT1) Fusion Protein in Patients with Surface CD3+ Malignant T Cell Diseases
Disease/Condition: Cancer | Non-Hodgkin's Lymphoma
Principal Investigator: Francine Foss
A Phase I/II Study of Cabazitaxel Combined with Abiraterone Acetate and Prednisone in Patients with Metastatic Castrate-Resistant Prostate Cancer (mCRPC) whose Disease has Progressed after Docetaxel Chemotherapy
Disease/Condition: Prostate
Principal Investigator: Daniel Petrylak
A Phase I/II Study of ISIS 481464, an Antisense Oligonucleotide Inhibitor of STAT3, Administered to Patients with Advanced Cancers
Disease/Condition: Lymphoid Leukemia
Principal Investigator: Joseph Paul Eder
A Phase I/II Study of the Combination of BKM120 and Bevacizumab, Glioblastoma Multiforme
Disease/Condition: Brain and Nervous System
Principal Investigator: Kevin Becker
A Phase I/II Study to Assess the Safety and Activity of Enhanced TCR Transduced Autologous T cells against Cancer-testis Antigens in Metastatic Melanoma
Disease/Condition: Melanoma, skin
Principal Investigator: Harriet Kluger
A Phase I/II, Open-label Study of Nivolumab Monotherapy or Nivolumab combined with Ipilimumab in Subjects with Advanced or Metastatic Solid Tumors
Disease/Condition: Breast - Female | Lung | Pancreas | Stomach
Principal Investigator: Joseph Paul Eder
A Phase I/IIa, First Time in human, open-label dose-escalation study of GSK2636771 in subjects with advanced solid tumors with PTEN deficiency
Disease/Condition: Brain and Nervous System | Breast - Female | Breast - Male | Breast Cancer (ER, PR, and HER2 negative) | Colon | Colorectal Cancer | Endometrial Cancer | Gastric Adenocarcinoma | Glioblastoma Multiforme | Head/ Neck Squamous Cell Carcinoma | Lip, Oral Cavity and Pharynx | Lung | Melanoma | Melanoma, skin | Non-Small Cell Lung Cancer (NSCLC) | Other Female Genital | Ovarian Cancer | Ovary | Prostate | Prostate Cancer | Rectum | Stomach
Principal Investigator: Joseph Paul Eder
A Phase Ib Multi-Cohort Study of MK-3475 in Subjects with Advanced Solid Tumors
Disease/Condition: Bladder | Breast - Female | Lip, Oral Cavity and Pharynx | Stomach
Principal Investigator: Lajos Pusztai
A Phase II Open Label Multicenter Study of PSMA ADC in Subjects with Castration-resistant Metastatic Prostate Cancer
Disease/Condition: Cancer | Prostate
Principal Investigator: Daniel Petrylak
A Phase II Study of Hsp90 Inhibitor AUY922 for the Treatment of Patients with Refractory Gastrointestinal Stromal Tumor
Disease/Condition: Cancer | Other Digestive Organ
Principal Investigator: Howard Hochster
A Phase II Study of MK-3475 in Patients with Metastatic Melanoma or Non-Small Cell Lung Cancer with Untreated Brain Metastases
Disease/Condition: Lung | Melanoma, skin
Principal Investigator: Harriet Kluger
A Phase II Trial of Carboplatin/Paclitaxel with and without Trastuzumab in HER2/neu+ Patients with Advanced orRecurrent Uterine Serous Papillary Cancer
Disease/Condition: Corpus Uteri
Principal Investigator: Alessandro Santin
A Phase II Trial of Response-Based Radiation Therapy for Pediatric Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT)
Disease/Condition: Brain and Nervous System
Principal Investigator: Nina Kadan-Lottick
A Phase II Trial to Examine the Effect of Subcutaneous Exenatide (Bydureon®) on Glucose Control in Patients with Type I Diabetes
Disease/Condition: Type 1 Diabetes
Principal Investigator: Kevan Herold
A PHASE II, MULTICENTER, RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP, PLACEBO-CONTROLLED STUDY TO INVESTIGATE THE EFFICACY AND SAFETY OF RO4602522 ADDED TO THE BACKGROUND THERAPY OF THE ACETYLCHOLINESTERASE INHIBITORS DONEPEZIL OR RIVASTIGMINE IN PATIENTS WITH MODERATE SEVERITY ALZHEIMER'S DISEASE
Disease/Condition: Alzheimer´s Disease
Principal Investigator: Christopher Van Dyck
A Phase II, Multicenter, Single-Arm Study of MPDL3280A in Patients with PD-L1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Disease/Condition: Lung
Principal Investigator: Scott Gettinger
A Phase II/III Randomized Trial of Two Doses of MK-3475 (SCH900475) versus Docetaxel in Previously Treated Subjects with Non-Small Cell Lung Cancer
Disease/Condition: Lung
Principal Investigator: Roy Herbst
A Phase IIb, Randomized, Double-blind Study Comparing Tremelimumab to Placebo in Second- or Third-line Treatment of Subjects with Unresectable Pleural or Peritoneal Malignant Mesothelioma
Disease/Condition: Lung
Principal Investigator: Sarah Goldberg
A Phase III Randomized Double-Blind Trial of Maintenance with Niraparib Versus Placebo in Patients with Platinum Sensitive Ovarian Cancer
Principal Investigator: Masoud Azodi
A Phase III Randomized Study of Adjuvant Ipilimumab Anti-CTLA4 Therapy Versus High-Dose Interferon a-2b for Resected High-Risk Melanoma (ECOG E1609)
Disease/Condition: Melanoma, skin
Principal Investigator: Harriet Kluger
A Phase III Randomized Trial Comparing Androgen Deprivation Therapy + TAK-700 With Androgen Deprivation Therapy + Bicalutamide in Patients With Newly Diagnosed Metastatic Sensitive Prostate Cancer
Disease/Condition: Prostate
Principal Investigator: Daniel Petrylak
A Phase III Randomized Trial for Patients with de novo AML using Bortezomib and Sorafenib for patients with High Allelic Ratio FLT3/ITD
Disease/Condition: Cancer | Myeloid and Monocytic Leukemia
Principal Investigator: Nina Kadan-Lottick
A Phase III Randomized Trial of Chemoembolization with or without Sorafenib in Unresectable Hepatocellular Carcinoma (HCC) in Patients with and without Vascular Invasion (ECOG 1208)
Disease/Condition: Liver | Liver Cancer
Principal Investigator: Stacey Stein
A Phase III Randomized Trial of Chemotherapy with or without Bevacizumab in Patients with Recurrent or Metastatic Head and Neck Cancer (ECOG E1305)
Disease/Condition: Head and Neck Cancer | Larynx | Lip, Oral Cavity and Pharynx
Principal Investigator: Hari Deshpande
A Phase III Randomized, Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in patients with High-Risk, Hormone Receptor-Positive and HER2/neu Negative Breast Cancer
Disease/Condition: Breast - Female | Breast - Male | Cancer
Principal Investigator: Maysa Abu-Khalaf
A Phase III Study of Risk Directed Therapy for Infants with Acute Lymnphoblastic Leukemia (ALL): Randomization of Highest Risk Infants to Intensive Chemotherapy +-FLT3 Inhibition
Disease/Condition: Leukemia, other
Principal Investigator: Nina Kadan-Lottick
A Phase III Trial of Adjuvant Chemotherapy as Primary Treatment for Locally Advanced Cervical Cancer Compared to Chemoradiation Alone: The Outback Trial
Principal Investigator: Peter Schwartz
A Phase III, Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes, Hormone Receptor-Positive and HER-2 Negative Breast Cancer with Recurrence Score (RS) of 25 or Less (SWOG S1007) (CIRB)
Disease/Condition: Breast - Female
Principal Investigator: Erin Hofstatter
A Phase III, Randomized, Double Blind, Placebo Controlled, Multicentre Study of Olaparib Maintenance Monotherapy in Patients with BRCA Mutated Advanced (FIGO Stage III-IV) Ovarian Cancer following First Line Platinum Based Chemotherapy.
Principal Investigator: Thomas Rutherford
A Randomized Controlled Trial of Routine Shave Margins Versus Standard Partial Mastectomy in Breast Cancer Patients
Disease/Condition: Breast - Female | Breast Cancer
Principal Investigator: Anees Chagpar
A Randomized Phase II trial of Neoadjuvant Cisplatin vs. Doxorubicin/Cyclophosphamide (AC) in Women with Newly Diagnosed Breast Cancer and Germline BRCA Mutations
Disease/Condition: Breast - Female | Breast - Male
Principal Investigator: Erin Hofstatter
A Randomized Phase II/III Trial of Surgery and Postoperative Radiation Delivered With Concurrent Cisplatin Versus Docetaxel Versus Docetaxel and Cetuximab for High-Risk Squamous Cell Cancer of the Head and Neck (RTOG 1216)
Principal Investigator: Roy Decker
A Randomized Phase IIB Study of Nivolumab or Nivolumab in Combination with Ipilimumab versus Bevacizumab in Adult Subjects with Recurrent Glioblastoma
Disease/Condition: Brain and Nervous System
Principal Investigator: Joachim Baehring
A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chestwall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy (NSABP B-51/RTOG 1304)
Disease/Condition: Breast - Female
Principal Investigator: Suzanne Evans
A Randomized Phase III Study Comparing Cabazitaxel/Prednisone in Combination with Custirsen (OGX-011) to Cabazitaxel/Prednisone for Second-Line Chemotherapy in Men with Metastatic Castrate Resistant Prostate Cancer
Disease/Condition: Prostate
Principal Investigator: Daniel Petrylak
A Randomized Phase III Study of Standard Cytarabine Plus Daunomycin (7+3) Therapy versus Idarubicin with High Dose Cytarabine (IA) with or without Vorinostat (IA+V) in Younger Patients with Previously Untreated Acute Myeloid Leukemia (AML)
Disease/Condition: Myeloid and Monocytic Leukemia
Principal Investigator: Nikolai Podoltsev
A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer
Disease/Condition: Breast - Female | Breast Cancer
Principal Investigator: Erin Hofstatter
A Randomized Phase III Trial of Cisplatin and Tumor Volume Directed Irradiation Followed by Carboplatin and Paclitaxel vs. Carboplatin and Paclitaxel for Optimally Debulked, Advanced Endometrial Carcinoma (GOG 0258) (CIRB)
Disease/Condition: Corpus Uteri | Endometrial Cancer
Principal Investigator: Masoud Azodi
A Randomized, Controlled Trial of Cranberry Capsules for UTI Prevention in Nursing Home Residents
Disease/Condition: Bacteriuria, Urinary tract infection (UTI)
Principal Investigator: Manisha Juthani-Mehta
A Randomized, Double-Blind, Placebo-Controlled Phase II Study Of Vtx-2337 In Combination With Pegylated Liposomal Doxorubicin (Pld) In Patients With Recurrent Or Persistent Epithelial Ovarian, Fallopian Tube Or Primary Peritoneal Cancer
Principal Investigator: Alessandro Santin
A Randomized, Double-Blind, Placebo-Controlled, Phase III Study to Evaluate the Efficacy and Safety of Afatinib (BIBW 2992) as Adjuvant Therapy After Chemo-Radiotherapy in Primary Unresected Patients with Stage III, IVa, or IVb Loco-Regionally Advanced Head and Neck Squamous Cell Carcinoma
Disease/Condition: Brain and Nervous System | Other Respiratory and Intrathoracic Organs
Principal Investigator: Anne Chiang
A Randomized, Double-Blinded, Placebo-Controlled Multiple Dose Study to Assess the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of BllB037 in Subjects with Prodromal or Mild Alzheimer's Disease
Disease/Condition: Alzheimer´s Disease
Principal Investigator: Christopher Van Dyck
A RANDOMIZED, MULTICENTER, ADAPTIVE PHASE II/III STUDY TO EVALUATE THE EFFICACY AND SAFETY OF TRASTUZUMAB EMTANSINE (T-DM1) VERSUS TAXANE (DOCETAXEL OR PACLITAXEL) IN PATIENTS WITH PREVIOUSLY TREATED LOCALLY ADVANCED OR METASTATIC HER2-POSITIVE GASTRIC CANCER, INCLUDING ADENOCARCINOMA OF THE GASTROESOPHAGEAL JUNCTION
Disease/Condition: Adenocarcinoma of the Gastroesophageal Junction | Esophagus | Gastric Cancer | Stomach
Principal Investigator: Howard Hochster
A Randomized, Multicenter, Double-Blind Phase III Study of PD-0332991 Plus Letrozole Versus Placebo Plus Letrozole for the Treatment of Postmenopausal Women with ER (+), HER2 (-) Breast Cancer who have not Received any Prior Systemic Anti-Cancer Treatment for Advanced Disease
Disease/Condition: Breast - Female
Principal Investigator: Maysa Abu-Khalaf
A Randomized, Multicenter, Open-label Phase III Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine versus Trastuzumab as Adjuvant Therapy for Patients with HER2-Positive Primary Breast Cancer who have Residual Tumor Present Pathologically in the Breast or Axillary Lymph Nodes following Preoperative Therapy (NSABP B50/Katherine Study)
Disease/Condition: Breast - Female | Breast - Male
Principal Investigator: Michael DiGiovanna
A Randomized, Open-Label, Phase II Study of Sipuleucel-T with Concurrent vs Sequential Administration of Enzalutamide in Men with Metastatic Castrate Resistant Prostate Cancer
Disease/Condition: Prostate
Principal Investigator: Daniel Petrylak
A Randomized, Phase 2, Open-Label Study Evaluating DN24-02 as Adjuvant Therapy in Subjects with High Risk HER2+ Urothelial Carcinoma
Disease/Condition: Bladder | Cancer
Principal Investigator: Hari Deshpande
A Randomized, Placebo Controlled, Parallel-Group, Double Blind Efficacy and Safety Trial of MK-8931 in Subjects with Mild to Moderate Alzheimer's Disease
Disease/Condition: Alzheimer´s Disease
Principal Investigator: Christopher Van Dyck
A Single Arm, Neoadjuvant, Phae II Trial of Pertuzumab and Trastuzumab Administered Concomitantly with Weekly Paclitaxel and FEC for Clinical Stage I-III HER2-Positive Breast Cancer
Disease/Condition: Breast - Female
Principal Investigator: Lajos Pusztai
A Study of CCCTC-binding Factor (CTCF) in Infantile Hemangiomas
Disease/Condition: Hemangioma
Principal Investigator: Deepak Narayan, MD
A Study to Examine the Human Gastrointestinal Tract Using the Confocal Endomicroscope
Disease/Condition: Digestive System Diseases
Principal Investigator: Michael Nathanson, MD, PhD
ACRIN 6690: A Prospective, Multicenter Comparison of Multiphase Contrast-Enhanced CT and Multiphase Contrast-Enhanced MRI for Diagnosis of Hepatocellular Carcinoma and Liver Transplant Allocation
Disease/Condition: Liver | Liver Cancer
Principal Investigator: Jeffrey Weinreb
Alcohol Pharmacotherapy for HIV+ Prisoners
Disease/Condition: AIDS | Alcohol Dependence | Hazardous Drinking | Human Immunodeficiency Virus | Problem Drinking
Principal Investigator: Frederick L Altice, MD
Amyloid imaging in subjects with and at risk for Alzheimer’s disease:- a positron emission tomography (PET) study
Disease/Condition: Alzheimer's Disease
Principal Investigator: Christopher H Van Dyck
An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF with Adjuvant Temozolomide in Patients with Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma
Disease/Condition: Brain and Nervous System | Glioblastoma
Principal Investigator: Kevin Becker
An Open Label, International, Multi-Center, Phase I/IIA Study of Lenalidomide (Revlimid) and Romidepsin (Istodax) for Relapsed/Refractory Hodgkin Lymphoma, Mature T-Cell Lymphoma and Multiple Myeloma (RID Study)
Disease/Condition: Hodgkin's Lymphoma | Multiple Myeloma | Non-Hodgkin's Lymphoma
Principal Investigator: Francine Foss
An open-label study to evaluate a novel LPA1 receptor ligand [11C]BMT-136088 ([11C]AM646) and to assess receptor occupancy in human lung following oral administration of BMS-986020 in healthy subjects
Disease/Condition: Lung fibrosis
Principal Investigator: Richard Carson
An Open-label, Multicenter, Randomized Phase II Study Evaluating the Safety and Efficacy of Docetaxel in Combination With IMC 1121B or IMC 18F1 or Without Investigational Therapy as Second line Therapy in Patients With Metastatic Transitional Cell Carcinoma of the Bladder, Urethra, Ureter, or Renal Pelvis Following Disease Progression on First-line Platinum-based Therapy
Disease/Condition: Bladder | Kidney | Other Urinary
Principal Investigator: Daniel Petrylak
An Open-label, Randomized Phase III Study of Inotuzumab Ozogamicin Compared to a Defined Investigator's Choice in Adult Patients with Relapsed or Refractory CD22-Positive Acute Lymphoblastic Leukemia (ALL)
Disease/Condition: Leukemia, other
Principal Investigator: Nikolai Podoltsev
Assessment of the Decision-making Impact of the Breast Cancer Index in Recommending Extended Adjuvant Endocrine Therapy for Patients with Early Stage ER-positive Breast Cancer
Principal Investigator: Tara Sanft
Atypical Lesions of the Breast: Close Observation vs. Excision (ALCOVE)
Principal Investigator: Brigid Killelea
BAN2401-G000-201: A Placebo-controlled, Double-blind, Parallel-group, Bayesian Adaptive Randomization Design and Dose Regimen-finding Study to Evaluate Safety, Tolerability and Efficacy of BAN2401 in Subjects With Early Alzheimer's Disease
Disease/Condition: Alzheimer´s Disease
Principal Investigator: Christopher Van Dyck
BATTLE-2 Program: A Biomarker-Integrated Targeted Therapy Study
Disease/Condition: Lung | Non Small Cell Lung Cancer
Principal Investigator: Roy Herbst
Biological Clock Dysfunction in Optic Nerve Hypoplasia
Disease/Condition: Biological Clock Dysfunction | Optic Nerve Hypoplasia
Principal Investigator: Rivkees, Scott A
Bronchial Thermoplasty in Severe Persistent Asthma
Disease/Condition: Severe Asthma
Principal Investigator: Geoffrey Chupp
Calcitonin for Treating X-linked Hypophosphatemia
Disease/Condition: Hypophosphatemic Rickets, X Linked Dominant
Principal Investigator: Karl Insogna
Cannabinoid Modulation of Pain
Disease/Condition: Pain
Principal Investigator: Richard A Sewell, M.D.
Cannabinoid Receptor Function & Alcoholism
Disease/Condition: Alcoholism
Principal Investigator: D'Souza, Deepak C.
Cannabinoids, Neural Synchrony, and Information Processing
Disease/Condition: Cannabis | Psychotic Disorders
Principal Investigator: D'Souza, Deepak C.
Carboplatin and Paclitaxel With or Without Bevacizumab and/or Cetuximab in Treating Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer
Disease/Condition: Lung | Lung Cancer | Non Small Cell Lung Cancer
Principal Investigator: Roy Herbst
Characterization of Tumor Cells in the Arterial and Venous Circulations of Non Small Cell Lung Cancer Patients
Disease/Condition: Non Small Cell Lung Cancer
Principal Investigator: Daniel J. Boffa
Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer
Disease/Condition: Fallopian Tube Cancer | Other Female Genital | Ovarian Cancer | Ovary | Primary Peritoneal Cavity Cancer
Principal Investigator: Thomas Rutherford
Chronic Alcohol and Brain Stress Circuit Response
Disease/Condition: Alcoholism | Stress
Principal Investigator: Rajita Sinha, PhD
Clinical Trial of Integrated Treatment for Pain and Opioid Dependence
Disease/Condition: Chronic Pain | Opiate Dependence
Principal Investigator: Schottenfeld, Richard S
Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III
Disease/Condition: Intraventricular Hemorrhage
Principal Investigator: David Greer
Cognitive Behavioral Therapy for Irritability and Disruptive Behavior in Children with High Functioning Autism Spectrum Disorders (ASD)
Disease/Condition: Asperger's Disorder | Autism | Autism Spectrum Disorder (ASD | Pervasive Developmental Disorder (PDD-NOS)
Principal Investigator: Denis Sukhodolsky, Ph.D.
Cognitive Enhancement as a Target for Cocaine Pharmacotherapy
Disease/Condition: Addiction
Principal Investigator: Mehmet Sofuoglu, M.D., Ph.D.
Cognitive Remediation and Work Therapy in the Initial Phase of Substance Abuse Treatment
Disease/Condition: Cognitive Impairment | Substance Abuse | Substance Dependence
Principal Investigator: Morris D Bell, Ph.D.
Cognitive Training to Enhance VA Work Program Outcomes
Disease/Condition: Bipolar Disorder | Depression | Mental Illness | PTSD | Schizophrenia
Principal Investigator: Morris D Bell, PhD
Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma
Disease/Condition: Sarcoma
Principal Investigator: Gary Kupfer
Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma
Disease/Condition: Adult Rhabdomyosarcoma | Childhood Desmoplastic Small Round Cell Tumor | Chordoma | Desmoid Tumor | Metastatic Childhood Soft Tissue Sarcoma | Nonmetastatic Childhood Soft Tissue Sarcoma | Previously Treated Childhood Rhabdomyosarcoma | Previously Untreated Childhood Rhabdomyosarcoma | Recurrent Adult Soft Tissue Sarcoma | Recurrent Childhood Rhabdomyosarcoma | Recurrent Childhood Soft Tissue Sarcoma | Soft Tissue | Stage I Adult Soft Tissue Sarcoma | Stage II Adult Soft Tissue Sarcoma | Stage III Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma
Principal Investigator: Nina Kadan-Lottick
Combination Chemotherapy in Treating Patients With Non-Metastatic Extracranial Ewing Sarcoma
Disease/Condition: Adult Supratentorial Primitive Neuroectodermal Tumor (PNET) | Childhood Supratentorial Primitive Neuroectodermal Tumor | Ewing Sarcoma of Bone | Extraosseous Ewing Sarcoma | Extraosseous Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor | Peripheral Primitive Neuroectodermal Tumor of the Kidney | Soft Tissue | Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor
Principal Investigator: Gary Kupfer
Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Liver Cancer
Disease/Condition: Childhood Hepatoblastoma | Liver | Stage I Childhood Liver Cancer | Stage II Childhood Liver Cancer | Stage III Childhood Liver Cancer | Stage IV Childhood Liver Cancer
Principal Investigator: Nina Kadan-Lottick
Compassionate Use of Mepolizumab in Subjects With Hypereosinophilic Syndrome (HES)
Disease/Condition: Hypereosinophilic Syndrome (HES)
Principal Investigator: Geoffrey Chupp
Computer Based Training in Cognitive Behavioral Therapy Web-based
Disease/Condition: Substance Abuse
Principal Investigator: Kathleen Carroll, PhD
Defibrotide for Patients with Hepatic Veno-Occlusive Disease (VOD)
Disease/Condition: Hepatic Veno-Occlusive Disease | Hodgkin's Lymphoma | Leukemia, not otherwise specified | Multiple Myeloma | Non-Hodgkin's Lymphoma
Principal Investigator: Stuart Seropian
Defibrotide for Patients With Hepatic Veno-occlusive Disease: A Treatment IND Study
Disease/Condition: Hepatic Veno-Occlusive Disease
Principal Investigator: Stuart Evan Seropian
Detecting heart disease using first pass imaging with Gated SPECT perfusion
Disease/Condition: Ischemic Heart Disease
Principal Investigator: Albert Sinusas
Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 2: Do Varenicline (Chantix) and Bupropion (Zyban) Change Alcohol Drinking?
Disease/Condition: Alcohol Drinking
Principal Investigator: Sherry McKee
Double-Blind, Proof-of-Concept (POC) Trial of Low Field Magnetic Stimulation (LFMS) Augmentation of Antidepressant Therapy in Treatment-Resistant Depression (TRD)
Disease/Condition: Depression
Principal Investigator: Gerard Sanacora
Eculizumab Therapy for Chronic Complement-Mediated Injury in Kidney Transplantation
Disease/Condition: Kidney Complications, Allograft
Principal Investigator: Sanjay Kulkarni
Effect of a Medium Chain Triglyceride Supplemented Diet on Cognitive Function and Brain Activation in Type 1 Diabetes.
Disease/Condition: Hypo-unawareness | Type 1 Diabetes
Principal Investigator: Robert Sherwin
Effect of Formoterol on the Counterregulatory Hormonal Response to Hypoglycemia in Type 1 Diabetes.
Disease/Condition: Type 1 Diabetes
Principal Investigator: Robert Sherwin
Effect of Naltrexone on Counterregulatory Mechanisms in Hypoglycemia
Disease/Condition: Hypoglycemia
Principal Investigator: Robert Sherwin
Effect of Subcutaneous RO4909832 on Cognition and Function in Prodromal Alzheimer's Disease
Disease/Condition: Alzheimer´s Disease
Principal Investigator: Christopher Van Dyck
Effect of Varenicline on Fixed-Dose Alcohol Administration in Participants with Alcohol Use Disorders
Disease/Condition: Alcohol Reactivity
Principal Investigator: Sherry McKee
Effectiveness and Cost Effectiveness of Peer Mentors in Reducing Hospital Use
Disease/Condition: Serious Mental Illness
Principal Investigator: Larry Davidson, PhD
Effects of Delta-9-THC and Iomazenil in Healthy Humans
Disease/Condition: Mental Disorders | Psychotic Disorders | Schizophrenia
Effects of Salvinorin A in Healthy Controls
Disease/Condition: Healthy
Principal Investigator: Ranganathan, Mohini
Efficacy and Tolerability of Riluzole in Treatment Resistant Depression
Disease/Condition: Depression
Principal Investigator: Gerard Sanacora
Efficacy, Safety and Tolerability of Everolimus in Combination With Reduced Exposure Cyclosporine or Tacrolimus in Paediatric Liver Transplant Recipients
Disease/Condition: Paediatric Liver Transplant Recipients
Principal Investigator: Manuel Rodriguez-Davalos
Enhancing a High School Based Smoking Cessation Program
Disease/Condition: Nicotine Dependence
Principal Investigator: Suchitra Krishnan-Sarin, Ph.D.
Evaluate the Safety and Efficacy of FG-3019 in Patients With Idiopathic Pulmonary Fibrosis
Disease/Condition: Idiopathic Pulmonary Fibrosis
Principal Investigator: Danielle Antin-Ozerkis
Evaluation of Safety and Efficacy of the FlexStent® Femoropopliteal Self-Expanding Stent System Study
Disease/Condition: Peripheral Artery Disease
Principal Investigator: Carlos Mena
Examination of Epigenetic Changes in Breast Tissue and Peripheral Blood of Women at Average versus Increased Risk of Breast Cancer
Disease/Condition: Breast Cancer | Cancer
Principal Investigator: Erin Hofstatter
FMRI of Stress and Addictive Disorders
Disease/Condition: Adolescents | Alcoholism | Cocaine Dependence | Opioid Dependence | Pathological Gamblers
Principal Investigator: Rajita Sinha, PhD
GABA-glutamate Interactions and Psychosis
Disease/Condition: Cognitive Dysfunction
Principal Investigator: Gunduz-Bruce, Handan
Galantamine to Enhance Cognitive Behavioral Therapy for Cocaine Abuse
Disease/Condition: Cocaine Dependence
Principal Investigator: Kathleen Carroll
Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer
Disease/Condition: Bladder | Distal Urethral Cancer | Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter | Proximal Urethral Cancer | Recurrent Bladder Cancer | Recurrent Prostate Cancer | Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter | Recurrent Urethral Cancer | Stage IV Bladder Cancer | Stage IV Prostate Cancer | Transitional Cell Carcinoma of the Bladder | Urethral Cancer Associated With Invasive Bladder Cancer
Principal Investigator: Hari Deshpande
Gender Differences in Self-Control, Food Choice, and Eating Behaviors in Obesity
Principal Investigator: Tomoko Udo Schaller
Genomic Research in Alpha-1 Antitrypsin Deficiency
Disease/Condition: AATD | Alpha 1 Antitrypsin Deficiency
Principal Investigator: Erica Herzog
Genomic Research in Sarcoidosis
Disease/Condition: Sarcoidosis
Principal Investigator: Erica Herzog
Glycemic Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE Study)
Disease/Condition: Diabetes Mellitus Type 2
Principal Investigator: William Tamborlane
Guanfacine for Children with Tic Disorders
Disease/Condition: Chronic Motor Tic Disorder | Chronic Vocal Tic Disorder | Tourette Syndrome
Principal Investigator: Lawrence D Scahill
Immune System Research in Rheumatoid Arthritis and Healthy Volunteers
Disease/Condition: Rheumatoid Arthritis
Principal Investigator: Erol Fikrig
Improving Adherence to Oral Cancer Agents and Self Care of Symptoms Using an IVR
Disease/Condition: Cancer
Principal Investigator: Elizabeth Ercolano
IncobotulinumtoxinA for treatment of focal cancer pain after surgery and/or radiation
Disease/Condition: Ill-Defined Sites
Principal Investigator: Bahman Jabbari
INSITE: Investigation of Sacroiliac Fusion Treatment
Disease/Condition: Degenerative Sacroiliitis | Sacroiliac Joint Disruption
Principal Investigator: Peter Whang
Integrated Brain, Body and Social Intervention for Attention Deficit Hyperactivity Disorder (ADHD)
Disease/Condition: Attention Deficit Hyperactivity Disorder (ADHD)
Principal Investigator: James Leckman, MD
Intergroup Trial for Children or Adolescents With B-Cell Non Hodgkin Lymphoma or B-Acute Leukemia: Evaluation of Rituximab Efficacy and Safety in High Risk Patients - Phase III Trial
Disease/Condition: Leukemia, other
Principal Investigator: Nina Kadan-Lottick
International Guillain-Barré Syndrome Outcome Study
Disease/Condition: Guillain-Barré Syndrome | Miller Fisher Syndrome
Principal Investigator: Richard Nowak
Intra-Operative Specimen Imaging in Breast Cancer Patients Undergoing Standard Partial Mastectomy: A Pilot of the Faxitron BioVision Wedge 3D versus BioVision 2D Imaging
Disease/Condition: Breast Cancer | Cancer
Principal Investigator: Anees Chagpar
Intravenous (IV) Nicotine Self Administration: Dose Ranging and Sex Differences in Smokers
Disease/Condition: Nicotine Addiction
Principal Investigator: Mehmet Sofuoglu, M.D,Ph.D.
Intravenous Alcohol Administration Using BrAc Method in Healthy Subjects With and Without a Family History of Alcoholism
Disease/Condition: Alcoholism
Principal Investigator: Ismene Leonida Petrakis
Investigation Into Effects Upon Counterregulatory Responses to Hypoglycemia During Intensive Treatment of T1DM
Disease/Condition: Hypoglycemia | Type 1 Diabetes
Principal Investigator: Robert Sherwin
Kappa-PET Imaging and Naltrexone in Alcohol Drinking Behaviors
Disease/Condition: Alcohol Drinking
Principal Investigator: Suchitra Krishnan-Sarin, Ph.D.
Ketamine for Depression and Alcohol Dependence
Disease/Condition: Alcohol Dependence | Depression
Principal Investigator: Ismene Leonida Petrakis
Ketamine/Placebo Family History Positive Study
Disease/Condition: Alcoholism
Principal Investigator: Petrakis, Ismene Leonida
Longitudinal Assessment and Functional Outcomes in Patients with Hematologic Malignancies and Related Disorders
Disease/Condition: Hematologic Malignancies
Principal Investigator: Stephanie Halene
Low Dose Parenteral Fat for Prevention of Parenteral Nutrition Associated Cholestasis in Preterm Neonates
Disease/Condition: Parenteral Nutrition-Associated Cholestasis
Principal Investigator: Richard A Ehrenkranz, MD
Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) Study
Disease/Condition: Emphysema
Principal Investigator: Gaetane Michaud
Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Younger Patients With Newly Diagnosed Ependymoma
Disease/Condition: Brain and Nervous System | Childhood Infratentorial Ependymoma | Childhood Supratentorial Ependymoma | Newly Diagnosed Childhood Ependymoma
Principal Investigator: Nina Kadan-Lottick
Microbiome Acquisition and Progression of Inflammation and Airway Disease in Infants and Children With Cystic Fibrosis
Disease/Condition: Cystic Fibrosis
Principal Investigator: Barbara I Kazmierczak, MD PhD
Minding the Baby Home Visiting: Program Evaluation
Disease/Condition: Attachment | Child Maltreatment | Infant Health | Maternal Sensitivity
Principal Investigator: Lois S Sadler, PhD
Modafinil, sleep architecture and cocaine relapse
Disease/Condition: Cocaine Dependence
Principal Investigator: Peter Morgan
Modeling Stress-precipitated Smoking Behavior for Medication Development
Disease/Condition: Smoking
Principal Investigator: Sherry McKee
Molecular Predictors of Radiation Resistance
Disease/Condition: Unknown Sites
Principal Investigator: Joseph Contessa
N-acetylcysteine (NAC) for Children With Tourette Syndrome
Disease/Condition: Tic | Tourettes Syndrome
Principal Investigator: Michael Bloch
N-acetylcysteine (NAC) for Pediatric Obsessive-Compulsive Disorder
Disease/Condition: Obsessive-Compulsive Disorder
Principal Investigator: Michael H. Bloch, MD, MS
Naltrexone and Memantine Effects on Alcohol Drinking Behaviors
Disease/Condition: Alcohol Drinking
Principal Investigator: Suchitra Krishnan-Sarin
Natural History Study of the Development of Type 1 Diabetes
Disease/Condition: Diabetes Mellitus, Type 1
Principal Investigator: Kevan Herold
Neural Correlates of Cognitive Rehabilitation in PTSD
Disease/Condition: Posttraumatic Stress Disorder | Traumatic Brain Injury
Principal Investigator: Brian Schweinsburg, Ph.D.
Neuroblastoma Antibody Study
Disease/Condition: Brain and Nervous System | Disseminated Neuroblastoma | Localized Resectable Neuroblastoma | Localized Unresectable Neuroblastoma | Regional Neuroblastoma | Stage 4S Neuroblastoma
Principal Investigator: Nina Kadan-Lottick
Neurofeedback for Tourette Syndrome
Disease/Condition: Chronic Tic Disorder | Tourette Syndrome
Principal Investigator: Michelle Hampson
Neurosurgery Patient Outcomes in Treating Spinal Disorders
Disease/Condition: Symptomatic Grade I Lumbar Spondylolisthesis | Symptomatic Lumbar Disc Herniation
Principal Investigator: Khalid M Abbed, MD
Newly Diagnosed High Risk B-Precursor ALL - Clofarabine
Disease/Condition: Leukemia, not otherwise specified
Principal Investigator: Nina Kadan-Lottick
Oral Insulin for Prevention of Diabetes in Relatives at Risk for Type 1 Diabetes Mellitus
Disease/Condition: Diabetes Mellitus, Type 1
Principal Investigator: Kevan Herold
Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery
Disease/Condition: Colon | Colorectal Cancer
Principal Investigator: Howard Hochster
Parent-Adolescent Interactions and Adolescent Development
Disease/Condition: Substance Abuse
Principal Investigator: Tara Chaplin, Ph.D.
PET Imaging of the Kappa Opioid Receptor in Humans
Disease/Condition: Healthy Subjects
Principal Investigator: Yiyun Huang
PET-Directed Therapy in Treating Patients With Limited-Stage Diffuse Large B-Cell Lymphoma
Disease/Condition: Limited-stage Diffuse Large B-Cell Lymphoma | Non-Hodgkin's Lymphoma
Pharmacogenetics of Cannabinoid Response
Disease/Condition: COMT Gene Polymorphism
Principal Investigator: D'Souza, Deepak C.
Phase Ib Trial of MPDL3280A with Bevacizumab or with Bevacizumab + FOLFOX in Patients with Solid Tumors
Disease/Condition: Colon | Lung | Rectum
Principal Investigator: Howard Hochster
Phase II Ipilimumab Monotherapy in Recurrent Platinum Sensitive Ovarian Cancer
Disease/Condition: Cancer
Principal Investigator: Alessandro Santin
Phase II neoadjuvant vemurafenib trial in melanoma patients with untreated brain metastases with B-raf mutations
Disease/Condition: Cancer | Melanoma, skin
Principal Investigator: Harriet Kluger
Phase II Study of Folfirinox for Advanced Pancreatic Cancer
Disease/Condition: Advanced Pancreatic Cancer | Metastatic Pancreatic Cancer | Pancreas | Pancreatic Cancer
Principal Investigator: Jill Lacy
Phase II Study of Peri-Operative Modified Folfirinox in Localized Pancreatic Cancer
Disease/Condition: Pancreas
Principal Investigator: Jill Lacy
Phase III Study of Postoperative Radiation Therapy (IMRT) +/- Cetuximab for Locally-Advanced Resected Head and Neck Cancer (RTOG 0920) (CIRB)
Disease/Condition: Head and Neck Cancer | Larynx | Lip, Oral Cavity and Pharynx
Principal Investigator: Roy Decker
Pilot Study of a Raltegravir Based NRTI Sparing Regimen
Disease/Condition: Acquired Immune Deficiency Syndrome | AIDS | HIV Infections | Human Immunodeficiency Virus
Principal Investigator: Michael J Kozal, MD
Pilot study of Image Guided RT for Stage 0 and 1 Breast Study
Disease/Condition: Breast - Female | Breast Cancer
Principal Investigator: Suzanne Evans
Prazosin for Treatment of Patients With Alcohol Dependence (AD) and Post Traumatic Stress Disorder (PTSD).
Disease/Condition: Alcohol Dependence | Stress Disorders, Post-Traumatic
Principal Investigator: Petrakis, Ismene Leonida
Prazosin to Reduce Stress-Induced Alcohol/Drug Craving and Relapse
Disease/Condition: Alcohol Dependence
Principal Investigator: Rajita Sinha
Prevalence of Carbohydrate Intolerance in Lean and Obese Children
Disease/Condition: Acanthosis Nigricans | Diabetes | Glucose Intolerance | Obesity
Principal Investigator: Sonia Caprio
Prevention of Type 2 Diabetes in Children With a Family-based Healthy Lifestyle Program
Disease/Condition: Impaired Glucose Tolerance
Principal Investigator: Robert S. Sherwin, MD
Radiation Therapy, Paclitaxel, and Carboplatin With or Without Trastuzumab in Treating Patients With Esophageal Cancer
Disease/Condition: Adenocarcinoma of the Esophagus | Adenocarcinoma of the Gastroesophageal Junction | Esophagus | Stage IB Esophageal Cancer | Stage IIA Esophageal Cancer | Stage IIB Esophageal Cancer | Stage IIIA Esophageal Cancer | Stage IIIB Esophageal Cancer
Principal Investigator: Bryan Chang
Randomized Phase II Trial of PET Scan-Directed Combined Modality Therapy in Esophageal Cancer
Disease/Condition: Esophagus
Principal Investigator: Daniel Boffa
Randomized, Double-Blind, Placebo-Controlled, Parallell-Group, 12-Month Trial of Leuco-methythionium bis(hydromethanesulfonate) in Subjects With Mild to Moderate Alzheimer's Disease
Disease/Condition: Alzheimer´s Disease
Principal Investigator: Christopher H Van Dyck
Reduce-IT
Disease/Condition: Hypertriglyceridemia
Principal Investigator: Sandip Kumar Mukherjee
Risk-Adapted Chemotherapy in Younger Patients With Newly Diagnosed Standard-Risk Acute Lymphoblastic Leukemia
Disease/Condition: B-cell Childhood Acute Lymphoblastic Leukemia | Leukemia | Lymphoid Leukemia | Philadelphia Chromosome Positive Adult Precursor Acute Lymphoblastic Leukemia | Untreated Adult Acute Lymphoblastic Leukemia | Untreated Childhood Acute Lymphoblastic Leukemia
Principal Investigator: Nina Kadan-Lottick
Risk-Based Classification System of Patients With Newly Diagnosed Acute Lymphoblastic Leukemia
Disease/Condition: Untreated Adult Acute Lymphoblastic Leukemia | Untreated Childhood Acute Lymphoblastic Leukemia
Principal Investigator: Nina Kadan-Lottick
Rituximab for Treatment of Systemic Sclerosis-Associated Pulmonary Arterial Hypertension (SSc-PAH)
Disease/Condition: Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Principal Investigator: Wassim Fares
RTOG 0815: Randomized Trial With or Without Short-Term Androgen Deprivation for Intermediate-Risk Prostate Cancer
Disease/Condition: Prostate | Prostate Cancer
Principal Investigator: Joseph Cardinale
Safety and Pharmacokinetic Study of Oral Morphine Sulfate in Pediatric Subjects
Disease/Condition: Pain
Principal Investigator: Haleh Saadat, MD
Safety of Twice Daily Oxycodone Hydrochloride Controlled-release Tablets in Children With Moderate to Severe Malignant and/ or Nonmalignant Pain Requiring Opioids
Disease/Condition: Pain
Principal Investigator: Haleh Saadat
Searching for Persistence of Infection in Lyme Disease
Disease/Condition: Borrelia Burgdorferi | Lyme Disease
Principal Investigator: Peter Krause
Selective Depletion of CD45RA+T Cells From Allogeneic Peripheral Blood Stem Cell Grafts for the Prevention of GVHD
Disease/Condition: Graft Versus Host Disease | Leukemia, not otherwise specified | Myelodysplastic Syndromes | Non-Hodgkin's Lymphoma
Principal Investigator: Warren Shlomchik
Sensitivity to Intravenous Nicotine: Genetic Moderators
Disease/Condition: Influence of OPRM1 A118G Status on Subjective Responses to IV Nicotine.
Principal Investigator: Mehmet Sofuoglu, M.D,Ph.D.
Social Cognitive Training for Psychosis: Treatment Development
Disease/Condition: Psychosis | Schizophrenia
Principal Investigator: Joanna M Fiszdon
STEAM (Sequencing Triplet with Avastin and Maintenance): Folfoxiri/Bevacizumab Regiments (Concurrent and Sequential) vs. Folfox/Bevacizumab in First-Line Metastatic Colorectal Cancer
Disease/Condition: Colon
Principal Investigator: Howard Hochster
Stress Management Among Latinos With Type 2 Diabetes
Disease/Condition: Diabetes Mellitus, Type 2
Principal Investigator: Rafael Pérez-Escamilla, Ph.D.
Stress Reactivity in Veterans Receiving Pharmacological Treatment for PTSD and Alcohol Dependence
Disease/Condition: Alcohol Dependence | Post-traumatic Stress Disorder
Principal Investigator: Elizabeth Ralevski, Ph.D.
Study of Kidney Tumors in Young Patients
Disease/Condition: Clear Cell Sarcoma of the Kidney | Congenital Mesoblastic Nephroma | Diffuse Hyperplastic Perilobar Nephroblastomatosis | Rhabdoid Tumor of the Kidney | Stage I Renal Cell Cancer | Stage I Wilms Tumor | Stage II Renal Cell Cancer | Stage II Wilms Tumor | Stage III Renal Cell Cancer | Stage III Wilms Tumor | Stage IV Renal Cell Cancer | Stage IV Wilms Tumor | Stage V Wilms Tumor
Principal Investigator: Gary Kupfer
Study of Late-Occurring Complications in Childhood Cancer Survivors
Disease/Condition: Cancer Survivor | Cardiovascular Complications | Hematopoietic/Lymphoid Cancer | Unspecified Childhood Solid Tumor, Protocol Specific
Principal Investigator: Kupfer, Gary
Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth
Disease/Condition: Beta-cell Function | Childhood Obesity | Impaired Glucose Tolerance | Insulin Resistance | Metabolic Syndrome | Pre-Diabetes
Principal Investigator: Sonia Caprio
T1DM Immunotherapy Using CD4+CD127lo/-CD25+ Polyclonal Tregs
Disease/Condition: Type 1 Diabetes Mellitus
Principal Investigator: Kevan Herold
Teplizumab for Prevention of Type 1 Diabetes In Relatives "At-Risk"
Disease/Condition: Autoantibody Positive | High Risk | Impaired Glucose Tolerance | Non-diabetic Relatives at Risk for Type 1 Diabetes
Principal Investigator: Kevan Herold
Text Messaging to Improve Adherence to Oral Chemotherapy Agents
Disease/Condition: Cancer
Principal Investigator: Elizabeth Ercolano
The Effect of Fatty Liver On Hepatic Gene Expression and Protein Activity
Disease/Condition: Obesity
Principal Investigator: Gerald Shulman
The Effects of ?-9-THC and Naloxone in Humans
Disease/Condition: Healthy
Principal Investigator: Deepak Cyril D''Souza
The Effects of Cannabidiol and ?-9-THC in Humans
Disease/Condition: Healthy
Principal Investigator: Mohini Ranganathan, M.D
The Genetics of Inflammatory Bowel Disease
Disease/Condition: Crohn's disease | Inflammatory Bowel Disease | Ulcerative Colitis
The MagnaSafe Registry: Determining the Risks of Magnetic Resonance Imaging (MRI) in the Presence of Pacemakers and Implantable Cardioverter Defibrillators (ICDs)
Disease/Condition: Implantable Cardioverter Defibrillator Implanted | Need for MRI Imaging With Pacemaker or
Principal Investigator: Rachel Lampert, MD
The MILO Study (MEK Inhibitor in Low-grade Serous Ovarian Cancer): A Multinational, Randomized, Open-label Phase III Study of MEK162 vs. Physician's Choice of Chemotherapy in Patients with Recurrent or Persistent Low-grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum
Principal Investigator: Thomas Rutherford
The PhenoGenetic Project
Disease/Condition: Healthy Subjects
Principal Investigator: Stephanie Eisenbarth
The Preoperative Health and Body (PREHAB) Study
Disease/Condition: Breast - Female
Principal Investigator: Melinda Irwin
The Role of Stress in Self-Control, Coping, and Emotion Regulation
Disease/Condition: Chronic Stress.
Principal Investigator: Rajita Sinha, PhD
Three-year Follow-up Study of Subjects Who Participated in a Previous Asunaprevir (BMS-650032) and/or Daclatasvir (BMS-790052) Chronic Hepatitis C Clinical Trial
Disease/Condition: Chronic Hepatitis C
Principal Investigator: Joseph Lim
TODAY Genetics Study
Disease/Condition: Type 2 Diabetes
Principal Investigator: Sonia Caprio
Transitions: Linkages From Jail To Community
Disease/Condition: HIV | HIV Infections | Substance Abuse
Principal Investigator: Frederick Altice, MD
Treatment of Refractory Schizophrenia With Riluzole
Disease/Condition: Schizoaffective | Schizophrenia
Principal Investigator: Zimolo, Zoran
Treatment with Mecamylamine in Smoking and Non-Smoking Alcohol Dependent Patients
Disease/Condition: Alcoholism
Understanding and Treating Disorders of Female Sexual Dysfunction
Disease/Condition: Female Sexual Dysfunction
Principal Investigator: Marsha Kathleen Guess
V212 (inactivated varicella-zoster virus vaccine) in Adult Patients with Solid Tumor or Hematologic Malignancies
Principal Investigator: Debra Brandt
Validation of the Gated Blood Pool SPECT: ERNA vs 3D Echo
Disease/Condition: Congestive Heart Failure | Ventricular Function, Left
Principal Investigator: Albert Sinusas
Varenicline Treatment of Alcohol Dependent Smokers
Disease/Condition: Alcohol Abuse | Alcohol Dependence | Smoking
Principal Investigator: Stephanie O'Malley
Web-based CBT4CBT for Alcohol
Disease/Condition: Alcohol Abuse or Dependence
Principal Investigator: Kathleen Carroll, PhD
Why Are Patients With Absence Seizures Absent? A Brain Imaging Study
Disease/Condition: Childhood Absence Epilepsy
Principal Investigator: Blumenfeld, Hal
Yale Pathology Tissue Services (YPTS) Tissue Banking Protocol
Principal Investigator: David Rimm
Yoga for Pain and Opioid Dependence
Disease/Condition: Chronic Pain | Opioid Addiction
Principal Investigator: Declan T Barry, Ph.D.
Ziprasidone in the Psychosis Prodrome
Disease/Condition: Psychosis Prodrome
Principal Investigator: Woods, Scott W