Genomic Research in Sarcoidosis
What is the purpose of this trial?
This project is designed to address the following hypothesis:
Distinct patterns in lung microbiome are characteristic of sarcoidosis phenotypes and reflected in changes in systemic inflammatory responses as measured by peripheral changes in gene transcription.
The Specific Aims are:
- To identify peripheral blood mononuclear cell (PBMC) gene expression patterns that characterize distinct sarcoidosis phenotypes.
- To determine whether patterns in the lung microbiome are associated with sarcoidosis severity and disease phenotypes
- To correlate mRNA and microRNA expression patterns in sarcoidosis affected organs with changes in microbiome, clinical parameters and PBMC gene expression patterns
- To integrate clinical, transcriptomic, and microbiome data to identify novel molecular phenotypes in sarcoidosis.
- 18 Years - 85 Years
- University of Pittsburgh
- Last Updated:
- Study HIC#: