Pilot Study of Gut Commensals in Antiphospholipid Syndrome


Antiphospholipid Syndrome (APS)

What is the purpose of this trial?

The purpose of this study is to explore if certain commensals within the gut microbiota (the collection of all microbes that live inside the gut) correlate with autoantibodies in the autoimmune clotting disorder called antiphospholipid syndrome. The study hypothesis is that particular commensals induce the autoantibodies (immune molecules that bind to self structures) and thus correlate with the level of immune cells and antibodies that are self-reactive. Participants are patients with antiphospholipid syndrome and individuals who have tested positive on a prior blood test for anti-beta2-glycoprotein I antibodies or those that have tested negative for antiphospholipid antibodies in their blood, but had a clotting event or a health problem that puts them at risk to form blood clots

Participation Guidelines

18 Years - 70 Years

Click here for detailed information about who can participate in this trial.

Yale University School of Medicine
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