Cannaboid Augmentation of Fear Response in Humans
What is the purpose of this trial?
The purpose of this double blind, randomized, controlled, proof-of-concept study is to test the effects of cannabinoid receptor augmentation on the facilitation of fear conditioning. On three days over not more than two weeks, subjects will be trained to associate cues with two different stimuli, then this association will be extinguished. Cannabinoid receptor stimulation will be accomplished both directly by administering the exogenous cannabinoid Δ9-tetrahydrocannabinol (THC) and indirectly by harnessing the brain's capacity to endocannabinoids through the administration of an enzyme (FAAH inhibitor) that prevents degradation of anandamide. Subjects will receive placebo, Δ9-tetrahydrocannabinol (THC) or the FAAH-inhibitor PF-04457845. Some details of this study have not been disclosed to preserve the study design.
- 18 Years - 65 Years
- Department of Veterans Affairs
- Last Updated:
- Study HIC#: