Study to Investigate the Pathophysiology of Type 2 Diabetes in Youth

Conditions

Childhood Obesity | Impaired Glucose Tolerance | Insulin Resistance | Metabolic Syndrome | Pre-diabetes

What is the purpose of this trial?

The purpose of the study is to determine the role of beta-cell function and insulin resistance in the development of impaired glucose tolerance (IGT) and type 2 diabetes in children and adolescents who have an increased risk of developing type 2 diabetes due to overweight/obesity or a family history of overweight/obesity, diabetes and/or impaired fasting glucose. It is hypothesized that: 1)Obese adolescents with IGT will be more insulin resistant than obese adolescents with NGT. Insulin resistance will be the best predictor of changes in glucose tolerance status., 2)Beta cell function will be impaired in obese adolescents with IGT compared to obese adolescents with NGT., 3)Obese adolescents with IGT will present with greater intramyocellular, intrahepatic and visceral fat than obese adolescents with NGT. Furthermore, obese adolescents with IGT will have larger adipocytes, while having significantly fewer adipocytes compared to obese adolescents with NGT. Obese adolescents with IGT will also have altered expression of key genes related to insulin resistance., and 4)Abnormalities in endothelial function as manifested by low FMD and PAT are already present in obese adolescents with IGT and are linked to insulin resistance.



Participation Guidelines

Age:
8 Years - 22 Years
Gender:
Both

Click here for detailed information about who can participate in this trial.


Sponsor:
Yale University
Dates:
September 2001
Last Updated:
June 16, 2014
Study HIC#:

Clinicaltrials.gov ID: NCT00536250