Glycemic Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE Study)


Diabetes Mellitus Type 2

What is the purpose of this trial?

This research study will compare the effectiveness of four different medications that are used to treat type 2 diabetes. Each of the 4 medications will be used together with metformin. Metformin is the medication used most often to treat type 2 diabetes. Each medication combination used in the GRADE study has been approved by the U.S. Food and Drug Administration (FDA) and is commonly used to treat type 2 diabetes in adults. However, no study has ever compared these combinations “head-to-head”. Therefore, which combination treatment is best for adults with type 2 diabetes is not known. The GRADE study will compare how well the different medication combinations control blood sugar levels. We will also look at other benefits or side effects of each medication combination. Information from the GRADE study will help to determine the best treatment for type 2 diabetes.

Participation Guidelines

30 Years and older

Click here for detailed information about who can participate in this trial.

National Institutes of Health
Last Updated:
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