Study of Post-meal Blood Sugar Peaks in Association With Vascular Disease in Childhood Obesity

Conditions

Cardiovascular Disease | Impaired Glucose Tolerance | Insulin Resistance | Pediatric Obesity

What is the purpose of this trial?

The main purpose of this study is to determine whether treatment with acarbose attenuates post-prandial glycemic excursions in non-diabetic/pre-diabetic obese children as determined by continuous glucose monitoring systems (CGMS). To this effect the current pilot study involves a 6 week intervention with acarbose given to all subjects with either impaired glucose tolerance or an area under the curve of >130 mg/dl during the screening oral glucose tolerance test. Three consecutive days of CGMS are then compared to before and during the intervention. The secondary objective addressed in this protocol is the collection of baseline measures of endothelial function in obese and lean children. Even though the duration of acarbose treatment may be too short to demonstrate a vascular effect, the pre and post intervention data would serve as preliminary data for anticipated future studies that assess the vascular effect of reduced post-prandial blood glucose levels.



Participation Guidelines

Age:
12 Years - 25 Years
Gender:
Both

Click here for detailed information about who can participate in this trial.


Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Yale University
Dates:
September 2006
Last Updated:
April 29, 2013
Study HIC#:
0603001202

Clinicaltrials.gov ID: NCT00846521