Virus-Related Publications

Sidney Altman

  • Yang, L., Wesolowski, D., Li, Y., and Altman, S. (2005) Analysis of putative RNase P RNA from orthopoxviruses. J. Mol. Biol.354:529-535.

Karen Anderson

  • Basavapathruni, A., Vingerhoets, J., de Bethune, M.P., Chung, R., Bailey, C.M., Kim, J., and Anderson, K.S. (2006) Modulation of human immunodeficiency virus type 1 synergistic inhibition by reverse transcriptase mutations. Biochemistry45:7334-7340.
  • Basavapathruni, A. and Anderson, K.S. (2006) Developing novel nonnucleoside HIV-1 reverse transcriptase inhibitors: beyond the butterfly. Curr. Pharm. Des.12:1857-1865.
  • Ruiz-Caro, J., Basavapathruni, A., Kim, J.T., Bailey, C.M., Wang, L., Anderson, K.S., Hamilton, A.D., and Jorgensen, W.L. (2006) Optimization of diarylamines as non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg. Med. Chem. Lett.16:668-671.
  • Jorgensen, W.L., Ruiz-Caro, J., Tirado-Rives, J., Basavapathruni, A., Anderson, K.S., and Hamilton, A.D. (2006) Computer-aided design of non-nucleoside inhibitors of HIV-1 reverse transcriptase. Bioorg. Med. Chem. Lett.16:663-667.
  • Ray, A.S., Hernandez-Santiago, B.I., Mathew, J.S., Murakami, E., Bozeman, C., Xie, N.Y., Dutschman, G.E., Gullen, E., Yang, Z., Hurwitz, S., Cheng, Y.C., Chu, C.K., McClure, H., Schinazi, R.F., and Anderson, K.S. (2005) Mechanism of anti-human immunodeficiency virus activity of beta-D-6-cyclopropylamino-2’,3’-didehydro-2’,3’-dideoxyguanosine. Antimicrob. Agents Chemother.49:1994-2001.

Warren Andiman

  • Alexander, L., Cuchura, L., Simpson, B.J., and Andiman, W.A. (2006) Virologic and host characteristics of human immunodeficiency virus type 1-infected pediatric long term survivors. Pediatr. Infect. Dis. J.25:135-141.

Janet Brandsma

  • Brandsma, J.L., Shylankevich, M., Su, Y., Zelterman, D., Rose, J.K., and Buonocore, L. (2009) Reversal of papilloma growth in rabbits therapeutically vaccinated against E6 without naked DNA and/or vesicular stomatitis virus vectors. Vaccine (In press).
  • Brandsma, J.L., Sun, Y., Lizardi, P.M., Tuck, D., Zelterman, D., Haines III, G.K., Martel, M., Harigopal, M., Schofield, K., and Neapolitano, M. (2009) Distinct human papillomavirus type 16 methylomes in cervical cells at different stages of premalignancy. Virology (In press).
  • Brandsma, J.L., Shylankevich, M., Su, Y., Roberts, A., Becker, S.M., Rose, J.K., Zelterman, D., and Buonocore, L. (2007) Vesicular stomatitis virus (VSV)-based therapeutic vaccination targeted to the E1, E2, E6, and E7 proteins of cottontail rabbit papillomavirus (CRPV). J. Virol.81:5749-5758.
  • Menon, G.K., Brandsma, J.L., and Schwartz, P.M. (2007) Particle mediated gene delivery and human skin: ultrastructural observations on stratum corneum barrier structures. Skin Pharmacol. Physiol.20:141-147.
  • Brandsma, J.L., Shylankevich, J., Buonocore, L., Roberts, A., Becker, S.M., and Rose, J.K. (2007) Therapeutic efficacy of vesicular stomatitis virus-based E6 vaccination in rabbits. Vaccine25:751-767.

Yung-Chi Cheng

  • Qin, X., Che, X., Wang, K., Polin, L., Kern, E.R., Drach, J.C., Gullen, E., Cheng, Y.C., and Zemlicka, J. (2006) Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides. Bioorg. Med. Chem.14:1247-1254.
  • Cheng, Y.C., Ying, C.X., Leung, C.H., and Li, Y. (2005) New targets and inhibitors of HBV replication to combat drug resistance. J. Clin. Virol.34S:S147-150.
  • Ambrose, A., Zemlicka, J., Kern, E.R., Drach, J.C., Gullen, E., and Cheng, Y.C. (2005) Phosphoralaninate pronucleotides of pyrimidine methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity. Nucleosides Nucleotides Nucl. Acids24:1763-1774.
  • Haraguchi, K., Takeda, S., Sumino, M., Tanaka, H., Dutschman, G.E., Cheng, Y.C., Nitanda, T., and Baba, M. (2005) A new approach to the synthesis of 4’-carbon-substituted nucleosides: development of a highly active anti-HIV agent 2’,3’-didehydro-3’-deoxy-4’-ethynylthymidine. Nucleosides Nucleotides Nucl. Acids24:343-347.
  • Tanaka, H., Haraguchi, K., Kumamoto, H., Baba, M., and Cheng, Y.C. (2005) 4’-Ethynylstavudine (4’-Ed4T) has potent anti-HIV-1 activity with reduced toxicity and shows a unique activity profile against drug-resistant mutants. Antivir. Chem. Chemother.16:217-221.
  • Nitanda, T., Wang, X., Kumamoto, H., Haraguchi, K., Tanaka, H., Cheng, Y.C., and Baba, M. (2005) Anti-human immunodeficiency virus type 1 activity and resistance profile of 2’,3’-didehydro-3’-deoxy-4’-ethynylthymidine in vitro. Antimicrob. Agents Chemother.49:3355-3360.

Susan Compton

  • Compton, S.R. (2008) Prevention of murine norovirus infection in neonatal mice by fostering. JAALAS47:25-30.
  • Smith, P.C., Nucifora, M., Reuter, J.D., and Compton, S.R. (2007) Reliability of soiled bedding transfer for the detection of mouse parvovirus and mouse hepatitis virus. Comp. Med.57:90-96
  • Compton, S.R., Ball-Goodrich, L.J., Johnson, L.K., Johnson, E.A., Paturzo, F.X., and Macy, J.D. (2004) Pathogenesis of enterotropic mouse hepatitis virus in immunocompetent and immunodeficient mice. Comp. Med. 54:681-689.
  • Compton, S.R., Jacoby, R.O., Paturzo, F.X., and Smith, A.L. (2004) Persistent Seoul virus infection in Lewis rats. Arch. Virol. 149:1325-1339.
  • Compton, S.R., Ball-Goodrich, L.J., Paturzo, F.X., and Macy, J.D. (2004) Transmission of enterotropic mouse hepatitis virus from immunocompetent and immunodeficient mice. Comp. Med. 54:29-35.

Peter Cresswell

  • Abdullah, N., Srinivasan, B., Modiano, N., Cresswell, P., and Sau, A.K. (2009) Role of individual domains and identification of internal gap in human guanylate binding protein-1. J. Mol. Biol.386:690-703.
  • Dong, G., Wearsch, P.A., Peaper, D.R., Cresswell, P., and Reinisch, K.M. (2009) Insights into MHC class I peptide loading from the structure of the tapasin/ERp57 heterodimer. Immunity30:21-32.
  • Hinson, E.R. and Cresswell, P. (2009) The N-terminal amphipathic-helix of viperin mediates localization to the cytosolic face of the endoplasmic reticulum and inhibits protein secretion. J. Biol. Chem.284:4705-4712.
  • Peaper, D.R. and Cresswell, P. (2008) The redox activity of ERp57 is not essential for its functions in MHC class I peptide loading. Proc. Natl. Acad. Sci. USA105:10477-10482.
  • Sealy, R., Chaka, W., Surman, S., Brown, S.A., Cresswell, P., and Hurwitz, J.L. (2008) Target peptide sequence within infectious HIV-1 does not ensure envelope-specific T-helper cell re-activation: influences of cysteine protease and gamma-interferon induced thiol reductase activities. Clin. Vac. Immunol.15:713-719.
  • Wang, X., Hinson, E.R., and Cresswell, P. (2007) The interferon-inducible protein viperin inhibits influenza virus release by perturbing lipid rafts. Cell Host Microbe2:96-105.
  • Wearsch, P.A. and Cresswell, P. (2007) Selective loading of high affinity peptides onto Major Histocompatibility Complex class I molecules by the tapasin-ERp57 heterodimer. Nat. Immunol.8:873-881.

Daniel DiMaio

  • Talbert-Slagle, K. and DiMaio, D. (2009) The bovine papillomavirus E5 protein and the PDGF beta receptor: It takes two to tango. Virology (minireview) 384:345-351.
  • Talbert-Slagle, K., Marlatt, S., Barrera, F.N., Khurana, E., Oates, J., Gerstein, M., Engelman, D.M., Dixon, A.M., and DiMaio, D. (2009) Artificial transmembrane oncoproteins smaller than the bovine papillomavirus E5 protein redefine sequence requirements for activation of the platelet-derived growth factor beta receptor. J. Virol.83:9773-9785.
  • Goodwin, E.C., Atwood, W.J., and DiMaio, D. (2009) High-throughput cell-based screens for chemicals that inhibit infection by Simian virus 40 and human polyomaviruses. J. Virol.83:5630-5639.
  • Yates, K.E., Korbel, G.A., Shtutman, M., Roninson, I.G., and DiMaio, D. (2008) Repression of the SUMO-specific protease Senp1 induces p53-dependent premature senescence in normal human fibroblasts. Aging Cell7:609-621.
  • Ptacek, J.B., Edwards, A.P.B., Freeman-Cook, L.L., and DiMaio, D. (2007) Packing contacts can mediate highly specific interactions between artificial transmembrane proteins and the PDGF beta receptor.  Proc. Natl. Acad. Sci. USA104:11945-11950.
  • Johung, K., Goodwin, E.C., and DiMaio, D. (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J. Virol. 81:2102–2116.
  • BookPapillomaviruses. (2007) Garcea, R. and DiMaio, D., eds., 430 pp. Springer.

Savithramma Dinesh-Kumar

  • Popescu, S.C., Popescu, G.V., Bachan, S., Zhang, Z., Gerstein, M., Snyder, M., and Dinesh-Kumar, S.P. (2009) MAPK target networks in Arabidopsis thaliana revealed using functional protein microarrays. Genes Dev.23:80-92. Epub 2008 Dec. 18.
  • Padmanabhan, M., Cournoyer, P., and Dinesh-Kumar, S.P. (2009) The leucine rich repeat domain in plant innate immunity: A wealth of possibilities. Cell Microbiol.11:191-198. Epub 2008 Nov. 3.
  • Caplan, J.C., Mamillapalli, P., Burch-Smith, T.M., Czymmek, K., and Dinesh-Kumar, S.P. (2008) Chloroplastic protein NRIP1 mediates innate immune receptor recognition of a viral effector. Cell132:449-462.
  • Caplan, J.C., Padmanabhan, M., and Dinesh-Kumar, S.P. (2008) Plant NB-LRR immune receptors: From recognition to transcriptional reprogramming. Cell Host & Microbe3:126-135.
  • Patel, S. and Dinesh-Kumar, S.P. (2008) Arabidopsis ATG6 is required to limit the pathogen-associated cell death response. Autophagy4:20-27.
  • Zhu, X. and Dinesh-Kumar, S.P. (2008) Virus induced gene silencing as a tool to identify host genes affecting viral pathogenicity. Meth. Mol. Biol.451:641-648.
  • Seay, M. and Dinesh-Kumar, S.P. (2007) Autophagy takes its TOLL on innate immunity. Cell Host & Microbe2:69-70.

Erol Fikrig

  • Town, T., Bai, F., Wang, T., Kaplan, A.T., Qian, F., Anderson, J.F., Montgomery, R., and Flavell, R.A., Fikrig, E. (2009) Tlr7 mitigates lethal West Nile encephalitis by affecting interleukin 23-dependent immune cell infiltration and homing. Immunity30:1-12.
  • Krishnan, M.N., Ng, A., Sukumaran, B., Gilfoy, F.D., Uchil, P.D., Sultana, H., Brass, A.L., Adametz, R., Tsui, M., Qian, F., Montgomery, R.R., Lev, S., Mason, P.W., Koski, R.A., Elledge, S.J., Xavier, R.J., Agaisse, H., and Fikrig, E. (2008) RNA interference screen for human genes associated with West Nile virus infection. Nature455:242-245.
  • Arjona, A., Foellmer, H.G., Town, T., Leng, L., McDonald, C., Wong, S.J., Montgomery, R.R., Fikrig, E., and Bucala, R. (2007) Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. J. Clin. Invest.117:3059-3066.

Durland Fish

  • Spielman, A., Andreadis, T.G., Apperson, C.S., Cornel, A.J., Day, J.F., Edman, J.D., Fish, D., Harrington, L.C., Kiszewski, A.E., Lampman, R., Lanzaro, G.C., Matuschka, F.R., Munstermann, L.E., Nasci, R.S., Norris, D.E., Novak, R.J., Pollack, R.J., Reisen, W.K., Reiter, P., Savage, H.M., Tabachnikc, W.J., and Wesson, D.M. (2004) Outbreak of West Nile virus in North America. Science306:1473-1475.

Frank Giordano

  • Yu, J., Lei, L., Liang, Y., Hinh, L., Hickey, R.P., Huang, Y., Liu, D., Yeh, J.L., Rebar, E., Case, C., Spratt, K., Sessa, W.C., and Giordano, F.J. (2006) An engineered VEGF-activating zinc finger protein transcription factor improves blood flow and limb salvage in advanced-age mice. FASEB J.20:479-481.
  • Tang, N., Wang, L., Esko, J., Giordano, F.J., Huang, Y., Gerber, H.P., Ferrara, N., and Johnson, R.S. (2004) Loss of HIV-1alpha in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis. Cancer Cell6:485-495.
  • Gratton, J.P., Yu, J., Griffith, J.W., Babbitt, R.W., Scotland, R.S., Hickey, R., Giordano, F.J., and Sessa, W.C. (2003) Cell-permeable peptides improve cellular uptake and therapeutic gene delivery of replication-deficient viruses in cells and in vivo. Nat. Med.9:357-362. (Erratum: Nat. Med.9:1221.)

Peter Glazer

  • Knauert, M.P., Kalish, J.M., Hegan, D.C., and Glazer, P.M. (2006) Triplex-stimulated intermolecular recombination at a single-copy genomic target. Mol. Ther.14:392-400.
  • Shahid, K.A., Majumdar, A, Alam, R., Liu, S.T., Kuan, J.Y., Sui, X., Cuenoud, B., Glazer, P.M., Miller, P.S., and Seidman, M.M. (2006) Targeted cross-linking of the human b-globin gene in living cells mediated by a triple helix forming oligonucleotide. Biochemistry45:1970-1978.
  • Kim, K.H., Nielsen, P.E., and Glazer, P.M. (2006) Site-specific gene modification by PNAs conjugated to psoralen. Biochemistry45:314-323.
  • Kalish, J.M. and Glazer, P.M. (2005) Targeted genome modification via triple helix formation. Ann.N.Y.Acad. Sci.1058:151-161.
  • Rogers, F.A., Lloyd, J.A., and Glazer, P.M. (2005) Triplex-forming oligonucleotides as potential tools for modulation of gene expression. Curr. Med. Chem. Anticancer Agents5:319-326.
  • Kalish, J.M., Seidman, M.M., Weeks, D.L., and Glazer, P.M. (2005) Triplex-induced recombination and repair in the pyrimidine motif. Nucl. Acids. Res.33:3492-3502.

Robert Heimer

  • Shaboltas, A.V., Toussova, O.V., Hoffman, I.F., Heimer, R., Verevochkin, S.V., Ryder, R.W., Khoshnood, K., Perdue, T., Masse, B.R., and Kozlov, A.P. (2006) HIV prevalence, sociodemographic, and behavioral correlates and recruitment methods among injection drug users in St. Petersburg, Russia. J. Acquir. Immune Defic. Syndr.41:657-663.
  • Uuskula, A., Heimer, R., Dehovitz, J., Fischer, K., and McNutt, L.A. (2005) Surveillance of HIV, hepatitis B virus, and hepatitis C virus in an Estonian injection drug-using population: sensitivity and specificity of testing syringes for public health surveillance. J. Infect. Dis.193:455-457.
  • Abdala, N., Crowe, M., Tolstov, Y., and Heimer, R. (2004) Survival of human immunodeficiency virus type 1 after rinsing injection syringes with different cleaning solutions. Subst. Use Misuse39:581-600.
  • Schmid, G.P., Buve, A., Mugyenyi, P., Garnett, G.P., Hayes, R.J., Williams, B.G., Calleja, J.G., De Cock, K.M., Whitworth, J.A., Kapiga, S.H., Ghys, P.D., Hankins, C., Zaba, B., Heimer, R., and Boerma, J.T. (2004) Transmission of HIV-1 infection in sub-Saharan Africa and effect of elimination of unsafe injections. Lancet363:482-488.

Akiko Iwasaki

  • Tal, M.C., Sasai, M., Lee, H.K., Yordy, B., Shadel, G.S., and Iwasaki, A. (2009) Absence of autophagy results in reactive oxygen species-dependent amplification of RLR signaling. Proc. Natl. Acad. Sci. USA106:2770-2775.
  • Lee, H.K., Zamora, M., Linehan, M.M., Iijima, N., Gonzalez, D., Haberman, A., and Iwasaki, A. (2009) Differential roles of migratory and resident DCs in T cell priming after mucosal or skin HSV-1 infection. J. Exp. Med.206:359-370.
  • Ichinohe, T., Lee, H.K., Ogura, Y., Flavell, R., and Iwasaki, A. (2009) Inflammasome recognition of influenza virus is essential for adaptive immune responses. J. Exp. Med.206:79-87.
  • Iijima, N., Linehan, M.M., Zamora, M., Butkus, D., Dunn, R., Kehry, M.R., Laufer, T.M., and Iwasaki, A. (2008) Dendritic cells and B cells maximize mucosal Th1 memory response to herpes simplex virus. J. Exp. Med.205:3041-3052.
  • Iwasaki, A. (2007) Mucosal dendritic cells. Annu. Rev. Immunol.25:381-418.
  • Lee, H.K., Lund, J.M., Ramanathan, B., Mizushima, N., and Iwasaki, A. (2007) Autophagy-dependent viral recognition by plasmacytoid dendritic cells. Science315:1398-1401.

Susan Kaech

  • Joshi, N.S., Cui, W., Chandele, A., Lee, H.K., Urso, D.R., Hagman, J., Gapin, L., and Kaech, S.M. (2007) Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity27:281-295.
  • Kaech, S.M. and Wherry, E.J. (2007) Heterogeneity and cell fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity (In Press).
  • Hand, T.W., Morre, M., and Kaech, S.M. (2007) Expression of IL-7 receptor alpha is necessary but not sufficient for the formation of memory CD8 T cells during viral infection. Proc. Natl. Acad. Sci. USA104:11730-11735.
  • Chandele, A. and Kaech, S.M. (2005) Memory CD8 T cell maturation occurs independently of CD8alphaalpha. J. Immunol.175:5619-5623.
  • Kaech, S.M., Tan, J.T., Wherry, E.J., Konieczny, B.T., Surh, C.D., and Ahmed, R. (2003) Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells. Nat. Immunol.4:1191-1198.
  • Kaech, S.M., Hemby, S., Kersh, E., and Ahmed, R. (2002) Molecular and functional profiling of memory CD8 T cell differentiation. Cell111:837-851.
  • Kaech, S.M. and Ahmed, R. (2001) Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells.Nat. Immunol.2:415-422.

Michael Kozal

  • Simen, B.B., Huppler-Hullsiek, K., Novak, R.M., MacArthur, R.D., Baxter, J.D., Huang, C., Lubeski, C., Turenchalk, G.S., Braverman, M.S., Desany, B., Simons, J.F., Rothberg, J.M., Egholm, M., and Kozal, M.J. (2009) Low abundance drug resistant viral variants in chronically HIV-infected antiretroviral-naïve patients significantly impact treatment. J. Infect. Dis.199:693-701.
  • Kozal, M.J. (2009) Drug-resistant human immunodeficiency virus. Supplement: Environmental changes, microbial systems and infections. Clin. Microbiol. Infect.1:69-73.
  • Kozal, M.J., et al. (2007)The incidence of HIV drug resistance and its impact on progression of HIV disease among antiretroviral naïve participants started on three different antiretroviral therapy strategies. HIV Clin. Trials6:357-370.
  • Desai, S.S., Kyriakides, T.C., Holodniy, M., Al-Salman, J., Griffith, B., and Kozal, M.J. (2007) Evolution of genotypic resistance algorithms and their impact on the interpretation of clinical trials: An OPTIMA trial substudy. HIV Clin. Trials8:293-302.
  • Lataillade, M., Chiarella, J., and Kozal, M.J. (2007) Natural polymorphism of the HIV-1 integrase gene. Antiviral Ther.12:563-570.
  • Kozal, M.J., Hullsiek, K.H., Leduc, R., Novak, R.M., MacArthur, R.D., Lawrence, J., Baxter, J.D., and Terry Beirn Community Programs for Clinical Research on AIDS (CPCRA). (2006) Prevalence and impact of HIV-1 protease codon 33 mutations and polymorphisms in treatment-naïve and treatment-experienced patients. Antivir. Ther.11:457-463.
  • MacArthur, R.D., Novak, R.M., Peng, G., Chen, L., Xiang, Y., Huppler-Hullsiek, K., Kozal, M.J., et al. (2006) A comparison of three highly active antiretroviral treatment strategies consisting of non-nucleoside reverse transcriptase inhibitors, protease inhibitors, or both in the presence of nucleoside reverse transcriptase inhibitors as initial therapy (CPCRA 058 FIRST Study): a long-term randomized trial. Lancet368:2125-2135.

Priti Kumar

  • Kumar, P., Ban, H.S., Kim, S.S., Wu, H., Pearson, T., Greiner, D., Laouar, A., Yao, J., Haridas, V., Habiro, K., Yang, Y.G., Jeong, J.H., Lee, K.Y., Kim, Y.K., Kim, S.W., Peipp, M., Fey, G.H., Manjunath, N., Shultz, L.N., Lee, S.K., and Shankar, P. (2008) T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice. Cell134:577-586.
  • Kumar, P., Wu, H., McBride, J.L., Jung, K.E., Moon, H.K., Davidson, B.L., Lee, S.K., Shankar, P., and Manjunath, N. (2007) Transvascular delivery of small interfering RNA to the central nervous system. Nature448:39-43.
  • Kumar, P., Lee, S.K., Shankar, P., and Manjunath, N. (2006) A single siRNA suppresses fatal encephalitis induced by two different flaviviruses. PLOS Med.3:e9.

Gary Kupfer

  • Durkin, S.S., Guo, X., Fryrear, K.A., Mihaylova, V.T., Gupta, S.K., Belgnaoui, S.M., Haoudi, A., Kupfer, G.M., and Semmes, O.J. (2008) HTLV-1 tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase. J. Biol. Chem.283:36311-36320.
  • Mihaylova, V.T., Green, A.M., Khurgel, M., Semmes, O.J., and Kupfer, G.M. (2008) Human T-cell leukemia virus 1 tax protein sensitizes p53-mutant cells to DNA damage Cancer Res.68:4843-4852.
  • Haoudi, A., Daniels, R.C., Wong, E., Kupfer, G., and Semmes, O.J. (2003) Human T-cell leukemia virus-1 tax oncoprotein functionally targets a subnuclear complex involved in cellular DNA damage-response. J. Biol. Chem.278:37736-37744.

Brett Lindenbach

  • von Hahn, T., Lindenbach, B.D., Boullier, A., Quehenberger, O., Paulson, M., Rice, C.M., and McKeating, J.A. (2006) Oxidized low-density lipoprotein inhibits hepatitis C virus cell entry in human hepatoma cells. Hepatology43:932-942.
  • Lindenbach, B.D., Meuleman, P., Ploss, A., Vanwolleghem, T., Syder, A.J., McKeating, J.A., Lanford, R.E., Feinstone, S.M., Major, M.E., Leroux-Roels, G., and Rice, C.M. (2006) Cell culture-grown hepatitis C virus in infectious in vivo and can be recultured in vitro. Proc. Natl. Acad. Sci. USA103:3805-3809.
  • Tscherne, D.M., Jones, C.T., Evans, M.J., Lindenbach, B.D., McKeating, J.A., and Rice, C.M. (2006) Time- and temperature-dependent activation of hepatitis C virus for low-pH-triggered entry. J. Virol.80:1734-1741.
  • Lindenbach, B.D. and Rice, C.M. (2005) Unravelling hepatitis C virus replication from genome to function. Nature436:933-938.
  • Lindenbach, B.D., Evans, M.J., Syder, A.J., Wolk, B., Tellinghuisen, T.L., Liu, C.C., Maruyama, T., Hynes, R.O., Burton, D.R., McKeating, J.A., and Rice, C.M. (2005) Complete replication of hepatitis C virus in cell culture. Science309:623-626.
  • Pfeffer, S., Sewer, A., Lagos-Quintana, M., Sheridan, R., Sander, C., Grasser, F.A., van Dyk, L.F., Ho, C.K., Shuman, S., Chien, M., Russo, J.J., Ju, J., Randall, G., Lindenbach, B.D., Rice, C.M., Simon, V., Ho, D.D., Zavolan, M., and Tuschi, T. (2005) Identification of microRNAs of the herpesvirus family. Nat. Methods2:269-276.

Laura Manuelidis

  • Manuelidis, L., Liu, Y., and Mullins, B. (2009) Strain-specific viral properties of variant Creutzfeldt-Jakob Disease (vCJD) are encoded by the agent and not by host prion protein. J. Cell Biochem.106:220-231.
  • Sun, R., Liu, Y., Zhang, H., and Manuelidis, L. (2008) Quantitative recovery of scrapie agent with minimal protein from highly infectious cultures. Viral Immunol.21:293-302.
  • Liu, Y., Sun, R., Chakrabarty, T., and Manuelidis, L. (2008) A rapid accurate culture assay for infectivity in transmissible encephalopathies. J. NeuroVirol.14:352-361.
  • Manuelidis L, Yu ZX, Banquero N, Mullins B. (2007) Cells infected with scrapie and Creutzfeldt-Jakob disease agents produce intracellular 25-nm virus-like particles. Proc Natl Acad Sci U S A. 104:1965-70.
  • Manuelidis, L. (2006) A 25nm virion is the likely cause of Transmissible Spongiform Encephalopathies. J. Cell Biochem.100:897-915.
  • Nishida, N., Katamine, S., and Manuelidis, L. (2005) Reciprocal interference between specific CJD and scrapie agents in neural cell cultures. Science310:493-496.

Richard Martinello

  • Martinello, R.A., Esper, F., Weibel, C., Ferguson, D., Landry, M.L., and Kahn, J.S. (2006) Human metapneumovirus and exacerbations of chronic obstructive pulmonary disease. J. Infect. (E-pub).

Robert Means

  • Mansouri, M., Douglas, J., Rose, P.P., Gouveia, K., Thomas, G., Means, R.E., Moses, A.V., and Fruh, K. (2006) Kaposi’s sarcoma herpesvirus K5 eliminates CD31/PECAM from endothelial cells. Blood108:1932-1940.
  • Chang, H., Gwack, Y., Kingston, D., Souvlis, J., Liang, X., Means, R.E., Cesarman, E., Hutt-Fletcher, L., Jung, J.U. (2005) Activation of CD21 and CD23 gene expression by Kaposi’s sarcoma-associated herpesvirus RTA. J. Virol.79:4651-4663.
  • Liang, X., Shin, YU.C., Means, R.E., and Jung, J.U. (2004) Inhibition of interferon-mediated antiviral activity by murine g-herpesvirus 68 latency-associated M2 protein. J. Virol.78:12416-12427.

Ruslan Medzhitov

  • Stetson, D.B. and Medzhitov, R. (2006) Antiviral defense: interferons and beyond. J. Exp. Med.203:1837-1841. Erratum in: J. Exp. Med.203:2215.
  • Kagan, J.C. and Medzhitov, R. (2006) Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell125:943-955.
  • Czopik, A.K., Bynoe, M.S., Palm, N., Raine, C.S., and Medzhitov, R. (2006) Semaphorin 7A is a negative regulator of T cell responses. Immunity24:591-600.
  • Barton, G.M., Kagan, J.C., and Medzhitov, R. (2006) Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA. Nat. Immunol.7:49-56.
  • van Duin, D., Medzhitov, R., and Shaw, A.C. (2006) Triggering TLR signaling in vaccination. Trends Immunol.27:49-55.
  • Qureshi, S.T., Zhang, X., Aberg, E., Bousette, N., Giaid, A., Shan, P., Medzhitov, R.M., and Lee, P.J. (2006) Inducible activation of TLR4 confers resistance to hyperoxia-induced pulmonary apoptosis. J. Immunol.176:4950-4958.

I. George Miller

  • Chen, L.-W., Raghavan, V., Chang, P.-J., Shedd, D., Heston, L., Delecluse, H.-J., and Miller, G. (2009) Two phenylalanines in the C-terminus of Epstein-Barr virus Rta protein reciprocally modulate its DNA binding and transactivation function. Virology386:448-461.
  • Park, R., Heston, L., Shedd, D., Delecluse, H.-J., and Miller, G. (2008) Mutations of amino acids in the DNA recognition domain of Epstein-Barr virus ZEBRA protein alter its sub-nuclear localization and affect formation of replication compartments. Virology382:145-162.
  • Countryman, J.K., Gradoville, L., and Miller, G. (2008) Histone hyperacetylation occurs on promoters of lytic cycle regulatory genes in Epstein-Barr virus-infected cell lines which are refractory to disruption of latency by histone deacetylase inhibitors. J. Virol.82:4706-4719.
  • Bhaduri-McIntosh, S., Rotenberg, M.J., Gardner, B., Robert, M., and Miller, G. (2008) Repertoire and frequency of immune cells reactive to Epstein-Barr virus-derived autologous lymphoblastoid cell lines. Blood111:1334-1343.
  • Ye, J., Gradoville, L., Daigle, D., and Miller, G. (2007) De Novo protein synthesis is required for lytic cycle reactivation of Epstein-Barr virus, but not Kaposi's sarcoma-associated herpesvirus, in response to histone deacetylase inhibitors and protein kinase C agonists. J. Virol.81:9279-9291.

Yorgo Modis

  • Nayak, V., Dessau, M., Kucera, K., Anthony, K., Ledizet, M., and Modis, Y. (2009) Crystal structure of dengue type 1 envelope protein in the postfusion conformation and its implication for receptor binding, membrane fusion and antibody recognition. J. Virol.83: (In press)
  • Arjona, A., Ledizet, M., Anthony, K., Bonafe, N., Modis, Y., Town, T., and Fikrig, E. (2007) Weset Nile virus envelope protein inhibits dsRNA-induced innate immune responses. J. Immunol.179:8403-8409.
  • Kanai, R., Kar, K., Anthony, K., Gould, L.H., Ledizet, M., Fikrig, E., Marasco, W.A., Koski, R.A., and Modis, Y. (2006) Crystal structure of West Nile virus envelope glycoprotein reveals viral surface epitopes. J. Virol. 80:11000-11008.
  • Modis, Y., Ogata, S., Clements, D., and Harrison, S.C. (2005) Variable surface epitopes in the crystal structure of dengue virus type 3 envelope glycoprotein. J. Virol.79:1223-1231.
  • Modis, Y., Ogata, S., Clements, D., and Harrison, S.C. (2004) Structure of the dengue virus envelope protein after membrane fusion. Nature427:313-319.

Walther Mothes

  • Chan, R., Uchil, P.D., Jin, J., Shui, G., Ott, D.E., Mothes, W., and Wenk, M.R. (2008) Retroviruses HIV and MLV are enriched in phosphoinositides. J. Virol.82:11228-11238.
  • Sherer, N.M. and Mothes, W. (2008) Tunneling nanotubes and cytonemes in cell-cell communication and viral pathogenesis. Trends Cell Bio. epub. doi:10.1016/j.tcb.2008.07.003.
  • Uchil, P.D., Quinlan, B., Chan, W.T., Luna, J.M., and Mothes, W. (2008) TRIIM E3 ligases interfere with early and late stages of the retroviral life cycle. PLoS Pathogens4: e16.doi:10.1317.
  • Sherer, N.M., Lehmann, N.M., Jimenez-Soto, L.F., Horensavitz, C., Pypert, M., and Mothes, W. (2007) Retroviruses can establish filopodial bridges for efficient cell-to-cell transmission. Nat. Cell Biol.9:310-315.
  • Lehmann, M.J., Sherer, N.M., Marks, C.B., Pypaert, M., and Mothes, W. (2005) Actin- and myosin-driven lateral movement of viruses along filopodia precedes their entry into cells. J. Cell Biol.170:317-325.

Anna Marie Pyle

  • Beran, R.K., Bruno, M.M., Bowers, H.A., Jankowsky, E., and Pyle, A.M. (2006) Robust translocation along a molecular monorail: the NS3 helicase from hepatitis C virus traverses unusually large disruptions in its track. J. Mol. Biol.358:974-982.
  • Dumont, S., Cheng, W., Serebrov, V., Beran, R.K., Tinoco, I., Jr., Pyle, A.M., and Bustamante, C. (2006) RNA translocation and unwinding mechanism of HCV NS3 helicase and its coordination by ATP. Nature439:105-108.
  • Serebrov, V. and Pyle, A.M. (2004) Periodic cycles of RNA unwinding and pausing by hepatitis C virus NS3 helicase. Nature430:476-480.
  • Kawaoka, J. and Pyle, A.M. (2005) Choosing between DNA and RNA: the polymer specificity of RNA helicase NPH-II. Nucl. Acids Res. 33:644-649.
  • Kawaoka, J., Jankowsky, E., and Pyle, A.M. (2004) Backbone tracking by the SF2 helicase NPH-II. Nat. Struct. Mol. Biol. 11:526-530.

Michael Robek

  • Garcia, M.L., Byfield, R., and Robek, M.D. (2009) Hepatitis B virus replication and release are independent of core lysine ubiquitination. J. Virol.83: ePub Feb. 25.
  • Pagliaccetti, N.E., Eduardo, R., Kleinstein, S.H., Mu, X.J., Bandi, P., and Robek, M.D. (2008) Interleukin-29 functions cooperatively with interferon to induce antiviral gene expression and inhibit HCV replication. J. Biol. Chem.283:30079-30089.
  • Ying, C., Li, Y., Leung, C.H., Robek, M.D., and Cheng, Y.C. (2007) Unique antiviral mechanism discovered in anti-hepatitis B virus research with a natural product analogue. Proc. Natl. Acad. Sci. USA104:8526-8531.
  • Wollmann, G., Robek, M.D., and van den Pol, A.N. (2007) Variable deficiencies in the interferon response enhance susceptibility to VSV oncolytic actions in glioblastoma but not in normal human glia. J. Virol.81:1479-1491.
  • Robek, M.D., Garcia, M.L., Boyd, B.S., and Chisari, F.V. (2007) Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus. J. Virol.81:483-491.

John Rose

  • Detje, C.N., Meyer, T., Schmidt, H., Kreuz, D., Rose, J.K., Bechmann, I., Prinz, M., and Kalinke, U. (2009) Local type I IFN receptor signaling protects against virus spread within the central nervous system. J. Immunol.182:2297-2304.
  • Schell, J., Rose, N.F., Fazo, N., Marx, P.A., Hunter, M., Ramsburg, E., Montefiori, D., Earl, P., Moss, B., and Rose, J.K. (2009) Long-term protection from AIDS and clearance of viral DNA following SHIV89.6P challenge. Vaccine27:979-986.
  • Chattopadhyay, A., Park, S., Delmas, G., Suresh, R., Senina, S., Perlin, D.S., and Rose, J.K. (2008) Single-dose, virus-vectored vaccine protection against Yersinia pestis challenge: CD4(+) cells are required at the time of challenge for optimal protection. Vaccine26:6329-6337.
  • Rose, N.F., Publicover, J., Chattopadhyay, A., and Rose, J.K. (2008) Hybrid alphavirus-rhabdovirus propagating replicon particles are versatile and potent vaccine vectors. Proc. Natl. Acad. Sci. USA105:5839-5843.
  • Liao, J.B., Publicover, J., Rose, J.K., and DiMaio, D. (2008) Single-dose, therapeutic vaccination of mice with vesicular stomatitis virus expressing human papillomavirus type 16 E7 protein. Clin. Vac. Immunol.15:817-824.
  • Kapadia, S.U., Simon, I.D., and Rose, J.K. (2008) SARS vaccine based on a replication-defective recombinant vesicular stomatitis virus is more potent than one based on a replication-competent vector. Virology376:165-172.
  • Wilson, S.R., Wilson, J.H., Buonocore, L., Palin, A., Rose, J.K., and Reuter, J.D. (2008) Intranasal immunization with recombinant vesicular stomatitis virus expressing murine cytomegalovirus glycoprotein B induces humoral and cellular immunity. Comp. Med.58:129-139.

Alanna Schepartz

  • Stephens, O.M., Kim, S., Welch, B.D., Hodsdon, M.E., Kay, M.S., and Schepartz, A. (2005) Inhibiting HIV fusion with a beta-peptide foldamer. J. Am. Chem. Soc. 127:13126-13127.
  • Kritzer, J.A., Stephens, O.M., Guarracino, D.A., Reznik, S.K., and Schepartz, A. (2005) beta-Peptides as inhibitors of protein-protein interactions. Bioorg Med Chem. 13:11-6.
  • Schneider, T.L. and Schepartz, A. (2001) Hepatitis B virus protein pX enhances the monomer assembly pathway of bZIP.DNA complexes. Biochemistry 40:2835-2843.
  • Pflum, M.K., Schneider, T.L., Hall, D., and Schepartz, A. (2001) Hepatitis B virus X protein activates transcription by bypassing CREB phosphorylation, not by stabilizing bZIP-DNA complexes. Biochemistry 40:693-703.

Christian Schlieker

  • Ernst, R., Mueller, B., Ploegh, H.L., and Schlieker, C. (2009) The otubain YOD1 is a deubiquitinating enzyme that associates with p97 to facilitate protein dislocation from the ER. Mol. Cell36:28-28.
  • Schlieker, C., Van der Veen, A.M., Damon, J.R., Spooner, E., and Ploegh, H.L. (2008) A functional proteomics approach links the Ubiquitin-related modifier Urm1 to a tRNA modification pathway. Proc. Natl. Acad. Sci. USA105:18255-18260.
  • Gredmark, S., Schlieker, C., Quesada, V., Spooner, E., and Ploegh, H.L. (2007) The large tegument protein (ORF64) of the mouse gamma-herpes MHV-68 encodes a functional ubiquitin-specific protease, expressed and active in the course of infection. J. Virol.81:10300-10309.
  • Schlieker, C., Weihofen, W.A., Frijns, E.A., Kattenhorn, L.M., Gaudent, R., and Ploegh, H.L. (2007) Structure of a herpesvirus-encoded cysteine protease reveals a new class of deubiquitinating enzymes. Mol. Cell25:677-687.
  • Schlieker, C., Korbel, G.A., Kattenhorn, L.M., and Ploegh, H.L. (2005) A ubiquitin deconjugating activity is conserved in the large tegument protein of Herpesviridae. J. Virol.79:15582-15585.

David Spiegel

  • Parker, C.G., Domaoal, R., Anderson, K.S., and Spiegel, D.A. (2009) An antibody-recruiting small molecule that targets HIV gp120. J. Am. Chem. Soc. (epub) PMID: 19839582.

Joan Steitz

  • Vasudevan, S., Tong, Y., and Steitz, J.A. (2008) Cell-cycle control of microRNA-mediated translation regulation. Cell Cycle7:1555-1559.
  • Conrad, N.K. (2008) Chapter 15. Co-immunoprecipitation techniques for assessing RNA-protein interactions in vivo.Meth. Enzymol.449:317-342.
  • Vasudevan, S., Tong, Y., and Steitz, J.A. (2007) Switching from repression to activation: microRNAs can upregulate translation. Science318:1931-1934.
  • Conrad, N.K., Fok, V., Cazalla, D., Borah, S., and Steitz, J.A. (2007) The challenge of viral snRNPs. CSH Symp Quant. Biol.71:337-384.
  • Conrad, N.K., Shu, M.-D., Uyhazi, K.E., and Steitz, J.A. (2007) Mutational analysis of a viral RNA element that counteracts rapid RNA decay by interaction with the polyadenylation tail. Proc. Natl. Acad. Sci. USA104:10412-10417.
  • Tycowski, K.T., Kolev, N.G., Conrad, N.K., Fok, V., and Steitz, J.A. (2006) The ever-growing world of small nuclear ribonucleoproteins. In: RNA World, 3rd ed. (Gesteland, R., Cech, T., and Atkins, J., eds.) pp. 327-368. CSHL Press, CSH, NY.
  • Hannon, G.J., Rivas, F.V., Murchison, E.P., and Steitz, J.A. (2006) The expanding universe of non-coding RNAs. CSH Symp. Quant. Biol.71:551-664.

Thomas Steitz

  • Durniak, K.J., Bailey, S., and Steitz, T.A. (2008) The structure of a transcribing T7 RNA polymerase complex captured during its transition from initiation to elongation. Science322:553-557.
  • Berman, A.J., Kamtekar, S., Goodman, J.L., Lázaro, J.M., de Vega, M., Blanco, L., Salas, M., and Steitz, T.A. (2007) Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases. EMBO J.26:3493-3505.
  • Kamtekar, S., Ho, R.S., Cocco, M.J., Li, W., Wenwieser, S.V., Boocock, M.R., Grindley, N.D., and Steitz, T.A. (2006) Implications of structures of synaptic tetramers of gamma/delta resolvase for the mechanism of recombination. Proc. Natl. Acad. Sci. USA103:10642-10647.
  • Kamtekar, S., Berman, A.J., Wang, J., Lazaro, J.M., de Vega, M., Blanco, L., Salas, M., and Steitz, T.A. (2006) The phi29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition. EMBO J.25:1335-1343.
  • Li, W., Kamtekar, S., Xiong, Y., Sarkis, G.J., Grindley, N.D., and Steitz, T.A. (2005) Structure of a synaptic gamma/delta resolvase tetramer covalently linked to two cleaved DNAs. Science309:1210-1215.

Richard Sutton

  • Poluri, A. and Sutton, R.E. (2008) Reduction in titer of shRNA-encoding HIV vectors by a DICER-dependent mechanism. Mol. Ther.16:378-386.
  • Coskun, A.K., van Maanen, M., Janka, D., Stockton, D., Stankiewicz, P., Yatsenko, S., and Sutton, R.E. (2007) Isolation and characterization of mouse-human microcell hybrid cell clones permissive for infectious HIV particle release. Virology362:283-293.
  • Baliga, C., van Maanen, M., Chastain, M., and Sutton, R.E. (2006) Vaccination of mice with replication-defective human immunodeficiency virus induces cellular and humoral immunity and protects against vaccinia virus-gag challenge. Mol. Ther.14:432-441.
  • Coskun, A.K., van Maanen, M., Nguyen, V., and Sutton, R.E. (2006) Human chromosome 2 carries a gene required for production of infectious human immunodeficiency virus type 1. J. Virol.80:3406-3415.

Peter Tattersall

  • Ruiz, Z., D'Abramo, A.M., Jr., and Tattersall, P. (2006) Differential roles for the C-terminal hexapeptide domains of NS2 splice variants during MVM infection of murine cells. Virology349:382-395.
  • Farr, G., Cotmore, S.F., and Tattersall, P. (2006) VP2 cleavage and the leucine ring at the base of the fivefold cylinder control pH-dependent externalization of both the VP1 N-terminus and the genome of Minute Virus of Mice. J. Virol.80:161-171.
  • Cotmore, S.F. and Tattersall, P. (2005) Parvoviruses, Chapter 29, in: DNA Replication in Eukaryotic Cells (2nd edition), DePamphilis, M.L., ed., CSHL Press, London, in press.
  • Farr, G., Zhang, L-G., and Tattersall, P. (2005) Parvoviral virions deploy a capsid-tethered lipolytic enzyme to breach the endosomal membrane during cell entry. Proc. Natl. Acad. Sci. USA102:17148-17153.
  • Cotmore, S.F. and Tattersall, P. (2005) Genome structure and organization, Chapter 7, in: The Parvoviruses, Kerr, J., Cotmore, S.F., Bloom, M.E., Linden, R.M., and Parrish, C.R., eds., Hodder Arnold, London,  pp. 73-94.
  • Cotmore, S.F. and Tattersall, P. (2005) A rolling hairpin strategy: basic mechanisms of DNA replication in the parvoviruses, Chapter 14, in: The Parvoviruses, Kerr, J., Cotmore, S.F., Bloom, M.E., Linden, R.M., and Parrish, C.R., eds., Hodder Arnold, London, pp. 171-188.

Paul Turner

  • Dennehy, J.J., Friedenberg, N.A., Holt, R.D., and Turner, P.E. (2006) Viral ecology and the maintenance of novel host use. Am. Nat.167:429-439.
  • Dennehy, J.J., Friedenberg, N.A., Yang, Y.W., and Turner, P.E. (2006) Bacteriophage migration via nematode vectors: host-parasite-consumer interactions in laboratory microcosms. Appl. Environ. Microbiol.72:1974-1979.
  • Duffy, S., Turner, P.E., and Burch, C.L. (2006) Pleiotropic costs of niche expansion in the RNA bacteriophage phi 6. Genetics172:751-757.
  • Silander, O.K., Weinreich, D.M., Wright, K.M., O’Keefe, K.J., Rang, C.U., Turner, P.E., and Chao, L. (2005) Widespread genetic exchange among terrestrial bacteriophages. Proc. Natl. Acad. Sci. USA102:19009-19014.
  • Montville, R., Froissart, R., Remold, S.K., Tenaillon, O., and Turner, P.E. (2005) Evolution of mutational robustness in an RNA virus. PloS Biol.3:e381.
  • Dennehy, J.J. and Turner, P.E. (2004) Reduced fecundity is the cost of cheating in RNA virus phi6. Proc. Biol. Sci.271:2275-2282.

Anthony Van den Pol

  • Wollmann, G., Robek, M.D., and Van den Pol, A.N. (2007) Variable deficiencies in the interferon response enhance susceptibility to VSV oncolytic actions in glioblastoma but not in normal human glia. J. Virol. 81:1479-1491.
  • Van den Pol, A.N., Robek, M.D., Ghosh, P.K., Ozduman, K., Bandi, P., Whim, M.D., and Wollmann, G. (2006) Cytomegalovirus induces interferon-stimulated gene expression and is attenuated by interferon in the developing brain. J. Virol. 80:332-348.
  • Van den Pol, A.N. (2006) Viral infections in the developing and mature brain. Trends Neurosci.29:398-406.
  • Reuter, J.D., Wilson, J.H., Idoko, K.E, and Van den Pol, A.N. (2005) CD4+ T-cell reconstitution reduces cytomegalovirus in the immunocompromised brain. J. Virol.79:9527-9539.
  • Wollmann, G., Tattersall, P., and Van den Pol, A.N. (2005) Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential. J. Virol.79:6005-6022.
  • Van den Pol, A.N., Acuna-Goycolea, C., Clark, K.R., and Ghosh, P.K. (2004) Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection. Neuron42:635-652.
  • Reuter, J.D., Gomez, D.L., Wilson, J.H., and Van den Pol, A.N. (2004) Systemic immune deficiency necessary for cytomegalovirus invasion of the mature brain. J. Virol.78:1473-1487.

Yong Xiong

  • Xiong, Y. and Steitz, T.A. (2006) A story with a good ending: tRNA 3'-end maturation by CCA-adding enzymes. Curr. Opin. Struct. Biol. 16:12-17.
  • Li, W., Kamtekar, S., Xiong, Y., Grindley, N.D., and Steitz, T.A. (2005) Structure of a synaptic resolvase tetramer covalently linked to two cleaved DNAs. Science309:1210-1215.
  • Xiong, Y. and Steitz, T.A. (2004) Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template. Nature430:640-645.
  • Xiong, Y., Li, F., Wang, J., Weiner, A.M., and Steitz, T.A. (2003) Crystal structures of an archaeal class I CCA-adding enzyme and its nucleotide complexes. Mol. Cell12:1165-1172.
  • Pan, B., Xiong, Y., Shi, K., and Sundaralingam. M. (2003) Crystal structure of a bulged RNA tetraplex at 1.1 Å resolution: Implications for a novel binding site in RNA tetraplexes. Structure11:1423-1430.