Clinical Trials

Bladder Cancer

10
A Phase I Study of the Safety and Pharmacokinetics of Escalating Doses of AGS15E Given as Monotherapy in Subjects with Metastatic Urothelial Cancer
Disease/Condition: Bladder
Principal Investigator: Daniel Petrylak
A Phase I, Open-label, dose-escalation study of the safety and pharmacokinetics of MPDL3280A administered intravenously as a single agent to patients with locally advanced or metastatic solid tumors or hematologic malignancies
Disease/Condition: Bladder | Breast - Female | Colon | Esophagus | Kidney | Larynx | Lip, Oral Cavity and Pharynx | Lung | Melanoma, skin | Multiple Myeloma | Non-Hodgkin's Lymphoma | Other Digestive Organ | Other Male Genital | Pancreas | Prostate | Rectum | Soft Tissue | Stomach | Thyroid
Principal Investigator: Roy Herbst
A Phase II, Multicenter, Single-Arm Study of MPDL3280A in Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer
Disease/Condition: Bladder
Principal Investigator: Daniel Petrylak
A Randomized, Phase 2, Open-Label Study Evaluating DN24-02 as Adjuvant Therapy in Subjects with High Risk HER2+ Urothelial Carcinoma
Disease/Condition: Bladder | Cancer
Principal Investigator: Hari Deshpande
Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer
Disease/Condition: Bladder | Distal Urethral Cancer | Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter | Proximal Urethral Cancer | Recurrent Bladder Cancer | Recurrent Prostate Cancer | Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter | Recurrent Urethral Cancer | Stage IV Bladder Cancer | Stage IV Prostate Cancer | Transitional Cell Carcinoma of the Bladder | Urethral Cancer Associated With Invasive Bladder Cancer
Principal Investigator: Hari Deshpande
Novartis Signature - LGX818 for pts with BRAFV600 mutated tumors
Disease/Condition: Bladder | Brain and Nervous System | Breast - Female | Esophagus | Eye and Orbit | Kidney | Larynx | Lip, Oral Cavity and Pharynx | Liver | Lung | Melanoma, skin | Other Skin | Ovary | Pancreas | Prostate | Rectum | Small Intestine | Soft Tissue | Stomach
Principal Investigator: Joseph Paul Eder

Kidney Cancer

Prostate Cancer

10
A Phase I/IIa, First Time in human, open-label dose-escalation study of GSK2636771 in subjects with advanced solid tumors with PTEN deficiency
Disease/Condition: Brain and Nervous System | Breast - Female | Breast - Male | Breast Cancer (ER, PR, and HER2 negative) | Colon | Colorectal Cancer | Endometrial Cancer | Gastric Adenocarcinoma | Glioblastoma Multiforme | Head/ Neck Squamous Cell Carcinoma | Lip, Oral Cavity and Pharynx | Lung | Melanoma | Melanoma, skin | Non-Small Cell Lung Cancer (NSCLC) | Other Female Genital | Ovarian Cancer | Ovary | Prostate | Prostate Cancer | Rectum | Stomach
Principal Investigator: Joseph Paul Eder
A Phase III Randomized Trial Comparing Androgen Deprivation Therapy + TAK-700 With Androgen Deprivation Therapy + Bicalutamide in Patients With Newly Diagnosed Metastatic Sensitive Prostate Cancer
Disease/Condition: Prostate
Principal Investigator: Daniel Petrylak
A Randomized Phase III Study Comparing Cabazitaxel/Prednisone in Combination with Custirsen (OGX-011) to Cabazitaxel/Prednisone for Second-Line Chemotherapy in Men with Metastatic Castrate Resistant Prostate Cancer
Disease/Condition: Prostate
Principal Investigator: Daniel Petrylak
A Randomized, Open-Label, Phase II Study of Sipuleucel-T with Concurrent vs Sequential Administration of Enzalutamide in Men with Metastatic Castrate Resistant Prostate Cancer
Disease/Condition: Prostate
Principal Investigator: Daniel Petrylak
RTOG 0815: Randomized Trial With or Without Short-Term Androgen Deprivation for Intermediate-Risk Prostate Cancer
Disease/Condition: Prostate | Prostate Cancer
Principal Investigator: Joseph Cardinale

Kidney & Urinary Tract

10
A Study to Evaluate the Efficacy and Safety of a Vaccine, ASP0113, in Cytomegalovirus (CMV)-Seronegative Kidney Transplant Recipients Receiving an Organ From a CMV-Seropositive Donor
Disease/Condition: Kidney Transplantation Cytomegalovirus (CMV) Negative Recipients
Principal Investigator: Peter Yoo
Eculizumab Therapy for Chronic Complement-Mediated Injury in Kidney Transplantation
Disease/Condition: Kidney Complications, Allograft
Principal Investigator: Sanjay Kulkarni
Open-Label Tolvaptan Study in Subjects With ADPKD (TEMPO 4/4)
Disease/Condition: Autosomal Dominant Polycystic Kidney Disease
Principal Investigator: Neera Dahl
Safety and Efficacy of MK-5172 + MK-8742 in Participants With Chronic Hepatitis C and Chronic Kidney Disease (MK-5172-052/C-SURFER)
Disease/Condition: Hepatitis C Virus
Principal Investigator: Michael Schilsky
The Norepinephrine Transporter: A Novel Target for Imaging Brown Adipose Tissue
Disease/Condition: Brown Adipose Tissue
Principal Investigator: Robert Sherwin

Men's Health

10
Imaging Cannabinoid Receptors Using Positron Emission Tomography (PET) Scanning
Disease/Condition: Cannabis Dependence | Family History of Alcoholism | Prodromal for Psychotic Illness | Schizophrenia
Principal Investigator: Deepak Cyril D''Souza

Women's Health

10
A Trial of Cranberry Capsules for Urinary Tract Infection Prevention in Nursing Home Residents
Disease/Condition: Bacteriuria
Principal Investigator: Manisha Juthani-Mehta
Compromised Microcirculation in Women With Polycystic Ovary Syndrome
Disease/Condition: Polycystic Ovary Syndrome
Principal Investigator: Nina S Stachenfeld
Stage I Randomized Trial of Mentalization-Based Therapy for Substance Using Mothers of Infants and Toddlers
Disease/Condition: Child Abuse and Neglect | Maternal Substance Abuse
Principal Investigator: Nancy Suchman
Study of the Elevate Anterior and Apical Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse
Disease/Condition: Anterior Pelvic Organ Prolapse | Apical Pelvic Organ Prolapse
Principal Investigator: Richard Bercik
Study of the Elevate Apical and Posterior Prolapse Repair System Compared to Native Tissue Repair for Pelvic Organ Prolapse
Disease/Condition: Posterior and Apical Pelvic Organ Prolapse | Posterior Pelvic Organ Prolapse
Principal Investigator: Richard Bercik
Study to Investigate Benefits of Weight Loss in Young Adults and Adolescents
Disease/Condition: Insulin Resistance | Obesity
Principal Investigator: Romy Kursawe
Understanding and Treating Disorders of Female Sexual Dysfunction
Disease/Condition: Female Sexual Dysfunction
Principal Investigator: Marsha Kathleen Guess