The Department of Therapeutic Radiology performs clinical research in almost all types of cancer including head and neck, breast, lung, Hodgkin's disease, non-Hodgkin's lymphomas, all of the major gastrointestinal cancers, glioblastoma multiforme and other neurological based malignancies, genito-urinary cancer, and the common childhood malignancies including Wilm's tumor, neuroblastoma and leukemia. The majority of these studies involve collaborative efforts with members of other departments, most commonly Medical Oncology, Pediatric Oncology and the various surgical sub-specialties. In addition to these intramural programs, the department offers patients the opportunity to participate in multi-institutional cooperative group trials, in addition to other collaborative inter-institutional endeavors.
Approximately 19,000 net square feet of laboratory space is presently available in the Department of Therapeutic Radiology. The majority of the laboratory space is located on the second and third floors of the Hunter Radiation Therapy building directly above the clinical area. Facilities for virology and bacteriology, biochemistry including nucleic acid chemistry, tissue culture, experimental animal tumor work, and others are available. Major renovations to improve and modernize this space are almost complete, funded in part by a substantial construction grant from the National Institute of Health.
There is a dual corridor animal care facility that includes radiation therapy facilities, and animal breeding and care facilities within the barrier. Investigators also of course can arrange and have access to other critical technologies from other parts of the Yale Comprehensive Cancer Center and Yale School of Medicine.
Laboratory research is performed in radiation biology, and radiologic physics by over ten separate groups, each consisting of a senior faculty member together with various pre- and post-doctoral fellows and technical assistants. The range of research interests varies from basic molecular and cancer biology to in vivo tumor biology and gene therapy approaches.
The Department of Therapeutic Radiology is an integral part of the Yale Comprehensive Cancer Center and benefits from well established relationships with other clinical and basic research departments.