Clinical Research

The Department of Therapeutic Radiology has a strong interest in the pursuit of research in various forms. The following are clinically related research studies in the Department of Therapeutic Radiology. The listing is a partial sample and additional active Clinical Trials can be found through the Yale Cancer Center.

Novel Approaches to Radiosensitize K-Ras Mutant Tumor Cells

  • Primary investigator-Bindra
  • Therapeutic Trial-No
  • Initiation date-8/12
  • Completion date-open
  • Funding source-N/A 

High-Throughput Screening for Small Molecule Inhibitors of Rhabdomyosarcoma Viability

  • Primary investigator-Bindra
  • Therapeutic Trial-No
  • Initiation date-8/12
  • Completion date-open
  • Funding source-N/A 

Investigation of Tumor DNA in Blood as a Cancer Biomarker

  • Primary investigator-Patel
  • Therapeutic trial-No
  • Initiation date-11/2009
  • Completion date-open
  • Funding source- ASTRO/Brozman Foundation/Yale Cancer Center

Molecular Determinants of Radiosensitivity in NSCLC

  • Primary investigator-Contessa (Johung)
  • Therapeutic trial-No
  • Initiation date- 1/12
  • Completion date-open
  • Funding source-N/A

PET Imaging of EGFR in Tumors

  • Primary investigator-Contessa
  • Therapeutic trial-No
  • Initiation date- 6/11
  • Completion date-open
  • Funding source-Kalimeris/Yale Center for Clinical Investigation

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(Additional Therapeutic Trails can be found through the Yale Cancer Center)

SEER evaluation of gender, race, and outcomes for cutaneous lymphoma

  • Primary investigator-Wilson 
  • Therapeutic trial-No 
  • Initiation date-7/11 
  • Completion date-open 
  • Funding source-NIH/Kalimeris

A Multicenter, Open-Label, Randomized, Phase I/II Study Evaluating the Safety and Efficacy of Low-Dose (12Gy) Total Skin Electron Beam Therapy (TSEBT) Combined With Vorinostat Versus Low-Dose TSEBT Monotherapy in Mycosis Fungoides (MF)

  • Primary investigator-Wilson 
  • Therapeutic trial-yes 
  • Initiation date-3/24/11 
  • Completion date-open 
  • Funding source: Stanford university/MERCK

A Pilot Study of Four-Dimensional Conformal Image Guided Accelerated Partial Breast Irradiation in the treatment of stage 0 and I breast carcinoma

  • Primary investigator-Evans 
  • Therapeutic trial-Yes 
  • Initiation date-1/2012 
  • Completion date-open 
  • Funding source-Cancer center

Dosimetric Predictors of Moist Desquamation in Breast Radiotherapy

  • Primary Investigator- Evans
  • Collaborators-Rutter, Higgins
  • Therapeutic trial-no
  • Initiation date-9/12
  • Completion date-IRB pending
  • Funding source-n/a

Predictors of Local Control in Inflammatory Breast Cancer

  • Primary Investigator- Evans
  • Collaborators-Taylor
  • Therapeutic Trial-no
  • Initiation date-9/12
  • Completion date-IRB pending
  • Funding source-n/a

Cost-Effectiveness Research and Radiation Oncology; An Analysis of the Existing Literature

  • Primary investigator - Dosoretz 
  • Therapeutic trial-No 
  • Initiation date-7/12 
  • Completion date-open 
  • Funding source- n/a

Academic Career Selection in Radiation Oncology: A Survey Across Time and Institution

  • Primary investigator - Dosoretz 
  • Therapeutic trial - no 
  • Initiation date - 3/12 
  • Completion date - open 
  • Funding Source - n/a

A Decision Analysis to Assess the Value of Prostate Cancer Screening: A Shift in Focus from Prostate Cancer Specific Mortality to Distant Metastasis Free Survival

  • Primary investigator - Dosoretz 
  • Therapeutic trial - no 
  • Initiation date - 2/12 
  • Completion date - open 
  • Funding Source - n/a

Histopathology of Post-Radiosurgery Imaging Changes

  • Primary investigator: Veronica Chiang 
  • Therapeutic trial: No 
  • Initiation date: 8/11 
  • Completion date: open 
  • Funding source: N/A
A Phase II Trial of MammoSite Breast Brachytherapy Optimization in the Treatment of Stage 0,I, and IIA Breast Carcinoma
  • Primary investigator: Joanne Weidhaas 
  • Therapeutic trial: Yes 
  • Initiation date: 05/06 
  • Completion date: open
  • Funding source: Yale

Immediate DIEP Breast Reconstruction and Post-Mastectomy Radiotherapy: Clinical Experience

  • Primary investigator: Susan Higgins 
  • Therapeutic trial: No 
  • Initiation date: 08/11 
  • Completion date: open 
  • Funding source: N/A

Chemotherapy and Intra-Vaginal Brachytherapy for Stage III Endometrial Cancer

  • Primary investigator- Damast, Young 
  • Therapeutic trial- No 
  • Initiation date- 1/12
  • Completion date- open 
  • Funding source- none

A comparison of three treatment strategies for locally advanced pancreatic cancer

  • Primary investigator-Bryan Chang / Shane Lloyd 
  • Therapeutic trial-No 
  • Initiation date-3/12 
  • Completion date-open 
  • Funding source-none

The Funding of Phase 3 Clinical Trials Examining Radiation Compared with That of Other Modalities

  • Primary investigator-James Yu / Shane Lloyd 
  • Therapeutic trial-No 
  • Initiation date-3/11 
  • Completion date-open 
  • Funding source-none

Stereotactic Radiosurgery for Older Cancer Patients with Early Stage Non-small Cell Lung Cancer: National Patterns of Care and Comparison with Surgery

  • Primary investigator-Yu 
  • Therapeutic trial-No 
  • Initiation date-7/12 
  • Completion date-open 
  • Funding source-YCCI

The PICK Pilot trial: Prostate Intensity Modulated Radiation Therapy versus Cyberknife Health Related Quality of Life (HRQoL) Trial

  • Primary investigator-Yu 
  • Therapeutic trial-No 
  • Initiation date-7/09 
  • Completion date-open 
  • Funding source-ACS

Clinical, socioeconomic, and geographic correlates to outcomes from cancer care using multiple large cancer databases, including SEER, the AMA masterfile, and state cancer profiles

  • Primary investigators-Yu, Aneja, Dosoretz, Park 
  • Therapeutic trial-No 
  • Initiation date-7/09 
  • Completion date-open 
  • Funding source-None

Clinical, socioeconomic, and geographic correlates to outcomes from cancer care using multiple large cancer databases

  • Primary investigators-Yu, Lloyd 
  • ]Therapeutic trial-No 
  • Initiation date-7/09 
  • Completion date-open 
  • Funding source-None

Boost vs. No Boost for Ductal Carcinoma In-Situ: A Multi-Institutional Evaluation

  • Primary investigator-Meena S. Moran 
  • Therapeutic trial-No, multi-institutional large retrospective cohort evaluating patients from MD Anderson, Dana Farber, William Beaumont, UPenn, UMDNJ, British Columbia and Yale Radiation Therapy Departments 
  • Initiation date- 2010 
  • Completion date-2013 
  • Funding source-Kalimeris

Racial Disparities Between African Americans and White Breast Cancer Veterans From The Veteran Affairs Central Registry Database

  • Primary investigator: Meena S. Moran 
  • Therapeutic trial: No, evaluation of the VA National Database in collaboration with Creighton University and University of Nebraska 
  • Initiation date- 2010 
  • Completion date-8/2012 
  • Funding source-none

Is Ki-67 a marker for local relapse in women undergoing breast conservation therapy?

  • Primary investigator: Meena S. Moran 
  • Therapeutic trial: No, tissue micro-array analysis 
  • Initiation date: 2010 
  • Completion date: Thesis project for Yale Med student graduating 2013 
  • Funding source: Kalimeris

Differences in Various Molecular Marker Over-Expression for Early-Stage Breast Cancer in African American and White Women

  • Primary investigator: Meena S. Moran 
  • Therapeutic trial: No, 
  • Initiation date: 2012 
  • Completion date-open 
  • Funding source-none

A Randomized Study of Lymphedema Screening Using Clinical Measurements Alone vs. Bioimpedance + Clinical Measurements for the Detection and Prevention of Chronic Lymphedema

  • Primary investigator: Meena S. Moran 
  • Therapeutic trial: No, but prospective, randomized clinical study 
  • Initiation date: 9/12 
  • Completion date-open 
  • Funding source-Backus Breast Foundation

Implementation and Utilization of Reflex Testing to Improve Time Lines in Breast Center Programs: A Prospective Study

  • Primary investigator: Meena S. Moran 
  • Therapeutic trial: No, but prospective clinical study 
  • Initiation date-9/09 
  • Completion date-1 year 
  • Funding source-None

Evaluation of the positive predictive value of BIRADS

  • Primary investigator: Meena S. Moran 
  • Therapeutic trial: No, but clinical study 
  • Initiation date-9/12- 
  • Completion date: 3 years-Yale Medical Student Thesis Project, graduating in 3 years 
  • Funding source-Yale School of Medicine

Hypofractionated Post-mastectomy Radiation Therapy

  • Primary investigator: Meena S. Moran 
  • Therapeutic trial: Yes 
  • Initiation date-10/12 
  • Completion date-3 years 
  • Funding source-Pending, Gateway Corp.

Do women of African American Race have increased local relapse after breast conservation therapy? A Meta-Analysis of the Published Data

  • Primary investigator: Meena S. Moran 
  • Therapeutic trial: Yes 
  • Initiation date-2012 
  • Completion date-open 
  • Funding source-None

Lung SBRT Database; including comparing biopsied vs. unbiopsied patients as well as multiple primary vs. single primary NSCLC

  • Primary investigator-Decker 
  • Therapeutic trial-No 
  • Initiation date-1/2012 
  • Completion date-open Funding source-N/A
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