Irvin M Modlin, MD, FRCS (Eng & Ed), FCS (SA)

Departments & Organizations

Gastrointestinal Procedure Center

Surgery: Biliary Tract Surgery

Biography

Dr Modlin is currently Professor of Gastroenterological Surgery at Yale University, School of Medicine and director of the GI Pathobiology Research Group. Dr. Modlin was born in Cape Town, South Africa and educated (sic) in Cape Town, Dublin, Leeds and London. He received a M.B, Ch B. magna summa cum laude and the Gold Medals for Surgery by both the South African College of Surgeons and the Royal College of Surgeons of Edinburgh in 1975. He trained in gastrointestinal surgery, advanced endoscopy and endocrine surgery at the Royal Postgraduate Medical School, Hammersmith Hosp, University of London (1975-1977) before joining the faculty at UCLA and the Center for Ulcer Research Education (1977-1979). In 1980 he joined the faculty at SUNY, New York and in 1984 was appointed Vice Chairman of the department of Surgery at Yale and Chief of Surgery at the West Haven Veterans Administration Medical Center. In 1989, the University of Cape Town awarded Dr. Modlin a Ph.D. in molecular physiology.

In 1990 he received a Fulbright scholarship (1989-1990) and in 1991 the University of Gothenburg in Sweden awarded him a M.D. (Hon. Causa). In 2005 he received a DSc. in gastroenterology for his work in the field of neuroendocrine biology. He has delivered the I.N. Marks lecture (Johannesburg, 1994), the Jena Polya Memorial Lecture (Budapest, 1995), the Arris and Gale lecture (London, 1995) and the Theodor Kocher Oration (Bern, 1996). In 1997, he was appointed Huntarian Professor by the Royal College of Surgeons of England and in 1998 received a fellowship. In 1999, he delivered the Bayliss and Starling Lecture at Queen’s University, Belfast and in 2000 the Centenary Oration at the Japanese Surgical Society. In 2002, the Royal College of Surgeons of Edinburgh appointed him a James IV Professor and in 2005 he received the Mikulicz medal of the Polish surgical society. He has received the Yale surgical teaching award on numerous occasions.

Dr Modlin’s current clinical interests are in neuro endocrine tumor disease therapy and esophagitis and his research focuses on the molecular basis of enterochromaffin cell function, neoplastic transformation and the mathematical modeling and identification of genetic signatures of metastasis. In 2007 he chaired the NCI Summit Conference on Neuroendocrine Tumor Disease in Washington DC and in 2008 the Neuroendocrine Tumor Pathology Consensus Summit. His investigative studies have been funded by the US Federal government and the National institutes of Health for more than two decades. Dr Modlin has been the distinguished guest and state of the art lecturer in over a hundred universities and medical schools in more than thirty countries. He has authored ~ 450 peer reviewed scientific and clinical papers and written ~16 books on subjects including Neuro endocrine tumor disease, Acid peptic disease, pancreatic maladies, laparoscopic surgery, GI endoscopy, the evolution of therapy, the history of medicine, the medical evolution of cities (Vienna, Rome, Birmingham, New Orleans, Washington, etc) and Dutch art. Currently his activities focus on therapeutic consensus development, the identification of viable advances in translational research as well as biotechnology interface assessment and application.

Education & Training

MD University of Capetown, South Africa (1968)
Chief Surgical Officer Hammersmith Hospital, London, England
Senior House Officer St. James Hospital, London, England
Registrar Groote Schuur Hospital
Resident Groote Schuur Hospital, Cape Town, South Africa
Intern Groote Schuur Hospital, Cape Town, South Africa
Intern Military Hospital, Pretoria, South Africa
Senior Surgical Registrar Hammersmith Hospital, London, England
Visiting Scientist University of California, Los Angeles, Center for Ulcer Research and Education (CURE), Los Angeles, CA
Fellow University of London

Honors & Recognition

  • Master of Arts, Honoris CausaYale University, New Haven, CT (1987)

  • Doctor of Medicine, Honoris CausaGoteborg, Sweden (1991)

  • Grand Global Award” for craftsmanshipA History of Gastroenterology at the Millennium (2001)

  • University of Cape Town Entrance ScholarshipUniversity of Cape Town, Cape Town, South Africa (1963)

  • University Medal For PhysiologyUniversity of Cape Town, Cape Town, South Africa (1964)

  • University Medal For MedicineUniversity of Cape Town, Cape Town, South Africa (1966)

  • University Medal For Chemical PathologyUniversity of Cape Town, Cape Town, South Africa (1967)

  • South African Society of Anaesthetists MedalSouth African Society of Anaesthetists (1967)

  • Urology Prize (1967)

  • Aaron Behrman Scholarship For The Best Student of The Year (1967)

  • Dowie Dunn Memorial Prize For Paediatrics (1968)

  • University Medal For SurgeryUniversity of Cape Town, Cape Town (1968)

  • Stabler Prize The Best Graduating Student In Surgery (1968)

  • ValedictorianUniversity of Cape Town Medical School, Cape Town, South Africa (1963), (1968)

  • University Gold Medal-Most Distinguished Graduate In MedicineUniversity of Cape Town, Cape Town, South Africa (1968)

  • The University of Cape Town Post-graduate Scholarship In Medicine University of Cape Town, Cape Town, South Africa (1968)

  • Degree Cum Laude and With Distinction In The Final Professional Examination University of Cape Town, Cape Town, South Africa (1968)

  • F.R.C.S. (Edinburgh) G.B. Ong Gold Medal - Most Distinguished Candidate (1975)

  • F.C.S. (South Africa) Gold Medal - Most Distinguished Candidate (1975)

  • South African Medical Research Council Overseas Scholarship (1976)

  • Wellcome Foundation Travelling Scholarship to LausanneWellcome Foundation (1977)

  • Wellcome Foundation Travelling Scholarship to LondonWellcome Foundation (1978)

  • E. Storer Teaching AwardYale University, New Haven, CT (1985)

  • Harvard Medical School Eisenberg Memorial LectureBrigham Hospital, Boston, MA (1988)

  • Fulbright Scholarship (1989)

  • Surgical Resident, Teaching AwardYale University, New Haven, CT (1992)

  • State-of-the-Art LecturerBritish Society of Gastroenterology (1993)

  • I. N. Marks Memorial LectureSouth African Gastroenterology Society (1994)

  • Polya Memorial LectureSemmelweis University (1994)

  • England-Arris and Gale LecturerRoyal College of Surgeons (1995)

  • Theodor Kocher Memorial LectureSwiss Surgical Society (1996)

  • State-of-the-Art Lecturer Japanese Society of Gastrointestinal Surgery (1997)

  • Fulton Society Lecture (1997)

  • Prout Society Lecture (1997)

  • Hunterian ProfessorshipRoyal College of Surgeons of England (1998)

  • The Beaumont Lecture (1999)

  • John Callum Memorial Oration (1999)

International Activity

  • Goeteborg Goeteborg, Sweden (2003)

    Perr Dubb Oration

  • Presentation- “The Molecular Basis of the ECL cell,” Per Dubb Oration Goeteborg, Sweden (2003)

    Presentation- “The Molecular Basis of the ECL cell,” Per Dubb Oration

  • Presentation- Current Status of GERD management, German Endoscopic society Hamburg, Germany (2003)

    Presentation- Current Status of GERD management, German Endoscopic society

  • Presentation- “From the Macula to the Mucosa,” Royal Society of Medicine London, United Kingdom (2003)

    Presentation- “From the Macula to the Mucosa,” Royal Society of Medicine

  • Keynote address, Indian Hepatobiliary Society India (2002)

    Keynote address, Indian Hepatobiliary Society

  • James the IV Oration Edinburgh, United Kingdom (2002)

    James the IV Oration

  • Examiner, University of Oman, Department Surgery Oman (2002)

    Examiner, University of Oman, Department Surgery

  • Invited speaker, “Cancer of Esophagus and Gastric Cardia: From Gene to Cure” Amsterdam, Netherlands (2002)

    Invited speaker, “Cancer of Esophagus and Gastric Cardia: From Gene to Cure”

  • Invited speaker, “Perspectives and reflections on integrated digestive surgery,” The Future of Gastro-Entero-Hepato-Pancreatology is Bright Amsterdam, Netherlands (2002)

    Invited speaker, “Perspectives and reflections on integrated digestive surgery,” The Future of Gastro-Entero-Hepato-Pancreatology is Bright

  • Invited speaker, “Amsterdam and Netherlands Gastroenterology: a historical perspective,” The Future of Gastro-Entero-Hepato Pancreatology is Bright Amsterdam, Netherlands (2002)

    Invited speaker, “Amsterdam and Netherlands Gastroenterology: a historical perspective,” The Future of Gastro-Entero-Hepato Pancreatology is Bright

  • Invited speaker, “Stem cells and mucosal dynamics: Regulation, repair and neoplasia,” Japanese Society of Ulcer Research Japan (2002)

    Invited speaker, “Stem cells and mucosal dynamics: Regulation, repair and neoplasia,” Japanese Society of Ulcer Research

  • Keynote address, Indian Hepatobiliary Society, “Surgery of chronic pancreatitis” India (2002)

    Keynote address, Indian Hepatobiliary Society, “Surgery of chronic pancreatitis”

  • James IV Oration, “Molecular strategies and 111In-labeled somatostatin analogs in defining the management of neuroendocrine tumor disease: A new paradigm for surgical management” Edinburgh, United Kingdom (2002)

    James IV Oration, “Molecular strategies and 111In-labeled somatostatin analogs in defining the management of neuroendocrine tumor disease: A new paradigm for surgical management”

  • Gastric Carcinoid Molecular Biology, Nordic Endocrine Society Meeting Iceland (2001)

    Gastric Carcinoid Molecular Biology, Nordic Endocrine Society Meeting

  • Invited Speaker International Pancreatic Meeting Heidelberg, Germany (2001)

    Invited Speaker International Pancreatic Meeting

  • Invited Speaker International Pancreatic Meeting Heidelberg, Germany (2001)

    Invited Speaker International Pancreatic Meeting

  • Invited Speaker, International Pancreatic Meeting, “The surgery of chronic pancreatitis—A chronicle of confusion and despair?” Germany (2001)

    Invited Speaker, International Pancreatic Meeting, “The surgery of chronic pancreatitis—A chronicle of confusion and despair?”

  • Keynote address: Minimally Invasive Endoscopic Society Heidelberg, Germany (2000)

    Keynote address: Minimally Invasive Endoscopic Society

  • Invited Speaker: “From k-Ras to Kagoshima,” 100-year Anniversary of the Japanese Surgical Society Tokyo, Japan (2000)

    Invited Speaker: “From k-Ras to Kagoshima,” 100-year Anniversary of the Japanese Surgical Society

  • Presentation- “Beyond Wittgenst," The Eastern Surgical Society: New Haven, United States (2000)

    Presentation- “Beyond Wittgenst," The Eastern Surgical Society:

  • Presentation- “The Evolution of Chronic Pancreatitis,” International Chronic Pancreatitis Symposium Bern, Switzerland (2000)

    Presentation- “The Evolution of Chronic Pancreatitis,” International Chronic Pancreatitis Symposium

  • Presentation- “The Molecular and Historic Basis of Barrett’s Esophagus," International Esophageal Meeting, Paris, France (2000)

    Presentation- “The Molecular and Historic Basis of Barrett’s Esophagus," International Esophageal Meeting,

  • Presentation Bermuda (2000)

    “From the Pump to the Helix,” International Helicobacter pylori Meeting

  • Hunterian Professorship London, United Kingdom (1999)

    Hunterian Professorship

  • Invited Speaker Veldhoven, Netherlands (1999)

    Invited Speaker, The Dutch Gastro Society, “The Golden Age of Dutch Medicine”

  • Invited Speaker, British Society of Surgery, “Carcinoid Biology and Surgery” Belfast, United Kingdom (1999)

    Invited Speaker, British Society of Surgery, “Carcinoid Biology and Surgery”

  • Royal College of Surgeons of England London, United Kingdom (1998)

    Royal College of Surgeons of England

  • Invited Speaker, The Theodor Kocher Memorial Lecture Bern, Switzerland (1996)

    Invited Speaker, The Theodor Kocher Memorial Lecture

  • Invited Speaker, Molecular Biology of Wound Healing, Japanese Gastroenterology Society Shimoda, Japan (1996)

    Invited Speaker, Molecular Biology of Wound Healing, Japanese Gastroenterology Society

  • Invited Speaker, Strategies of GERD management Bangkok, Thailand (1996)

    Invited Speaker, Strategies of GERD management

  • Invited Speaker, Gastroesophageal Reflux Disease: Back to Surgery? Bern, Switzerland (1996)

    Invited Speaker, Gastroesophageal Reflux Disease: Back to Surgery?

  • Invited Speaker, Consensus Workshop for Surgical Treatment of Neuroendocrine Gastroenteropancreatic Tumors Berlin, Germany (1996)

    Invited Speaker, Consensus Workshop for Surgical Treatment of Neuroendocrine Gastroenteropancreatic Tumors

  • Co-Organizer/Session Chairman, International Meeting, Current Research in Gastrointestinal Disease: The African Perspective Cape Town, South Africa (1995)

    Co-Organizer/Session Chairman, International Meeting, Current Research in Gastrointestinal Disease: The African Perspective

  • Invited Speaker, Polya Memorial Lecture Budapest, Hungary (1995)

    Invited Speaker, Polya Memorial Lecture

  • Invited Speaker, The Arris and Gale Lecture, "The Pathophysiology of the Fundic Enterochromaffin- like (ECL) Cell and Gastric Carcinoid Tumors" London, England, United Kingdom (1995)

    Invited Speaker, The Arris and Gale Lecture, "The Pathophysiology of the Fundic Enterochromaffin- like (ECL) Cell and Gastric Carcinoid Tumors"

  • Session Chairman, International Meeting, Five Years of Laparoscopic Cholecystectomy: A Reappraisal Bern, Switzerland (1995)

    Session Chairman, International Meeting, Five Years of Laparoscopic Cholecystectomy: A Reappraisal

  • Invited Speaker, International Workshop on New Trends in the management of Pancreatic Disease, The Managment of Acute Pancreatitis- Who Are We Kidding? Messina, Italy (1995)

    Invited Speaker, International Workshop on New Trends in the management of Pancreatic Disease, The Managment of Acute Pancreatitis- Who Are We Kidding?

  • Prout Club, London London, United Kingdom (1994)

    Prout Club, London

  • Invited Speaker, British Society of Gastroenterology Prout Club Meeting Edinburgh, Scotland, United Kingdom (1994)

    Invited Speaker, British Society of Gastroenterology Prout Club Meeting

  • Invited Speaker, International Meeting, Pancreatic Diseases, New Horizons - Chronic Pancreatitis: Pre-cancerous disease? Bern, Switzerland (1994)

    Invited Speaker, International Meeting, Pancreatic Diseases, New Horizons - Chronic Pancreatitis: Pre-cancerous disease?

  • Invited Speaker, SAGES Congress - Solly Marks lecture: The new gastric creed of the third milennium Sun City, South Africa (1994)

    Invited Speaker, SAGES Congress - Solly Marks lecture: The new gastric creed of the third milennium

  • Invited Speaker, Reunion Annuelle Du GRESZE - Experimental models of ECLomas Paris, France (1994)

    Invited Speaker, Reunion Annuelle Du GRESZE - Experimental models of ECLomas

  • Invited Speaker Munchsmunster, Germany (1994)

    Invited Speaker, Carcinoid Tumors - International Symposium on Pathology, Epidemiology, Clinical Aspects and Therapy

  • Invited Speaker Tuebingen, Germany (1993)

    Invited Speaker, Tissue Repair-Wound Healing Mechanisms, Therapeutic Implications

  • Invited Speaker, Molecular and Cell Biological Aspects of Gastroenteropancreatic Neuroendocrine Tumor Disease Berlin, Germany (1993)

    Invited Speaker, Molecular and Cell Biological Aspects of Gastroenteropancreatic Neuroendocrine Tumor Disease

  • Visiting Professor London, United Kingdom (1993)

    Visiting Professor

  • Visiting Professor Dublin, Ireland (1993)

    Visiting Professor

  • Visiting Professor London, England, United Kingdom (1993)

    Visiting Professor

  • Visiting Professor Glasgow, United Kingdom (1993)

    Visiting Professor

  • Visiting Professor United Kingdom (1993)

    Visiting Professor

  • Visiting Professor United Kingdom (1993)

    Visiting Professor

  • Invited Speaker, Molecular Mechanisms of Mucosal Healing Antalya, Turkey (1993)

    Invited Speaker, Molecular Mechanisms of Mucosal Healing

  • Athenaeum Club, London London, United Kingdom (1992)

    Athenaeum Club, London

  • Royal Club, Current Perspectives in Acute Pancreatitis Evian-les-Bains, France (1992)

    Royal Club, Current Perspectives in Acute Pancreatitis

  • Medical and Surgical Management of Carcinoid Tumors Padova, Italy (1992)

    Medical and Surgical Management of Carcinoid Tumors

  • Israel Gastroenterology Association Eilat, Israel (1992)

    Israel Gastroenterology Association

  • European Acid Suppression Workshop London, United Kingdom (1991)

    European Acid Suppression Workshop

  • Chairman, Surgical Section of the Advisory Board, International Gastro-Surgical Club (1990)

    Chairman, Surgical Section of the Advisory Board, International Gastro-Surgical Club

  • World Conference on Gastroenterology, Pathophysiology of Acute Pancreatitis Sydney, Australia (1990)

    World Conference on Gastroenterology, Pathophysiology of Acute Pancreatitis

  • Pancreatitis Symposium Marburg an der Lahn, Germany (1990)

    Pancreatitis Symposium, Subcellular Activation of Pancreatic Enzyme

  • Experimental Ulcer Conference Berlin, Germany (1990)

    Experimental Ulcer Conference

  • Swedish Endocrine Society Goeteborg, Sweden (1990)

    Swedish Endocrine Society

  • Falk Symposium, TGF a Secretory Regulation of Parietal Cells Freiburg, Germany (1990)

    Falk Symposium, TGF a Secretory Regulation of Parietal Cells

  • Oncogene Amplification in Gastric ECLoma Tumors Lund, Sweden (1990)

    Oncogene Amplification in Gastric ECLoma Tumors

  • Pathobiology of Acute Pancreatitis Hong Kong, China (1989)

    Pathobiology of Acute Pancreatitis

  • Bleeding in Portal Hypertension Taormina, Italy (1989 - 1989)

    Presentation- Pathophysiology of Bleeding in Portal Hypertension

  • Surgery of Peptic Ulceration Rome, Italy (1989 - 1989)

    Surgery of Peptic Ulceration

  • Mechanisms of ECL Cell Neoplasia Florence, Italy (1989 - 1989)

    Mechanisms of ECL Cell Neoplasia

  • Pathobiology of the Endocrine Stomach Umea, Sweden (1989)

    Pathobiology of the Endocrine Stomach

  • Mechanisms of Intracellular Zymogen Activation Bern, Switzerland (1989)

    Mechanisms of Intracellular Zymogen Activation

  • Surgical Management of Pancreatitis Cape Town, South Africa (1989)

    Surgical Management of Pancreatitis

  • The ECL Quincunx Rome, Italy (1989)

    The ECL Quincunx

  • Pathogenesis of Pancreatitis South Africa (1989)

    Pathogenesis of Pancreatitis

  • From Prout to the Proton Pump Cape Town, South Africa (1989)

    From Prout to the Proton Pump

  • The Adoration of the Vagi Goeteborg, Sweden (1988)

    The Adoration of the Vagi

  • Nordic Endocrine Society, Cholecystokinin Receptor Antagonists Sweden (1988)

    Nordic Endocrine Society, Cholecystokinin Receptor Antagonists

  • International Gastro-Surgical Club (1987)

    International Gastro-Surgical Club

  • Examiner Edinburgh, United Kingdom (1985 - 2003)

  • World Gut Hormone Symposium: Evidence for a Non-Gastrin pH Dependent Mechanism of Bombesin Stimulated Gastric Acid Secretion Stockholm, Sweden (1982)

    World Gut Hormone Symposium: Evidence for a Non-Gastrin pH Dependent Mechanism of Bombesin Stimulated Gastric Acid Secretion

  • World Gut Hormone Symposium: Evidence for a Non-Gastrin pH Dependent Mechanism of Bombesin Stimulated Gastric Acid Secretion Stockholm, Sweden (1982)

    World Gut Hormone Symposium: Evidence for a Non-Gastrin pH Dependent Mechanism of Bombesin Stimulated Gastric Acid Secretion

  • World Gut Hormone Symposium: The Release of Pancreatic Polypeptide by Xenopsin Florence, Italy (1981)

    World Gut Hormone Symposium: The Release of Pancreatic Polypeptide by Xenopsin

  • Royal Society of Medicine of England United Kingdom (1980)

    Royal Society of Medicine of England

  • International Association of Endocrine Surgeons (1980)

    International Association of Endocrine Surgeons

  • International Society of Surgery (1980)

    International Society of Surgery

  • World Gut Hormone Symposium Cambridge, United Kingdom (1980)

    Release of Substance P by a Meal

  • World Gut Hormone Symposium Cambridge, United Kingdom (1980)

    Cholinomimetric Modulation of PP Release

  • World Gut Hormone Symposium Cambridge, United Kingdom (1980)

    Intestinal Phase of PP Release

  • World Gut Hormone Symposium: Atropine Resistant CCK Like Peptide Release Norway (1978)

    World Gut Hormone Symposium: Atropine Resistant CCK Like Peptide Release

  • World Gut Hormone Symposium: Effect of Motilin on Gastric Emptying Oslo, Norway (1978)

    World Gut Hormone Symposium: Effect of Motilin on Gastric Emptying

  • VIP, British Society of Gastroenterology, A New Component of the Autonomic Nervous System United Kingdom (1977)

    VIP, British Society of Gastroenterology, A New Component of the Autonomic Nervous System

  • British Regional Hospital Pharmaceutical Course, Adrenal Surgery United Kingdom (1977)

    British Regional Hospital Pharmaceutical Course, Adrenal Surgery

  • Royal Postgraduate Medical School surgical Course: Aspects of Colonic Angiodysplasia United Kingdom (1977)

    Royal Postgraduate Medical School surgical Course: Aspects of Colonic Angiodysplasia

  • British Surgical Research Society: Mechanisms of Motilin Release United Kingdom (1977)

    British Surgical Research Society: Mechanisms of Motilin Release

  • European Surgical Research Society: Motilin Release in the Pig Warsaw, Poland (1977)

    European Surgical Research Society: Motilin Release in the Pig

  • Royal Society of Medicine: Haemorrhage in Reduplications of the Duodenum United Kingdom (1976)

    Royal Society of Medicine: Haemorrhage in Reduplications of the Duodenum

  • British Endocrine Society.: VIP Release in Intestinal Ischemia United Kingdom (1976)

    British Endocrine Society.: VIP Release in Intestinal Ischemia

  • University of London Surgical Endocrinology Symposium: Phaechromocytoma Management. United Kingdom (1976)

    University of London Surgical Endocrinology Symposium: Phaechromocytoma Management.

  • British Postgraduate Medical Federation Gastroenterology Course: Multi Hormone Secreting Gut Tumors United Kingdom (1976)

    British Postgraduate Medical Federation Gastroenterology Course: Multi Hormone Secreting Gut Tumors

  • University of London MSc Course in Clinical Biochemistry: APUDomas of the Gut United Kingdom (1976)

    University of London MSc Course in Clinical Biochemistry: APUDomas of the Gut

  • Postgraduate Gastroenterology Teaching Course, St. Charles Hospital London, United Kingdom (1976)

    Postgraduate Gastroenterology Teaching Course, St. Charles Hospital

  • International Gut Hormone Symposium: VIP Pharmacokinetics Lausanne, Switzerland (1976)

    International Gut Hormone Symposium: VIP Pharmacokinetics

  • British Society of Gastroenterology: VIP and Diarrhea United Kingdom (1976)

    British Society of Gastroenterology: VIP and Diarrhea

  • Royal College of Surgeons of Edinburgh Edinburgh, United Kingdom (1975)

    Royal College of Surgeons of Edinburgh

  • South African College of Surgeons South Africa (1975)

    South African College of Surgeons

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Contact Info

Irvin M Modlin, MD, FRCS (Eng & Ed), FCS (SA)
Patient Care Location
Yale Surgical SpecialtiesYale Physicians Building
800 Howard Avenue, Ste 3rd Floor

New Haven, CT 06519
Office Location
Tompkins Memorial Pavilion
789 Howard Avenue, Ste Room 202

New Haven, CT 06519
Mailing Address
Yale SurgeryPO Box 208062
New Haven, CT 06520-8062