David H Stitelman, MD

Assistant Professor of Surgery (Pediatrics)

Research Organizations


Research Summary

The level of sophistication of prenatal imaging and genetic diagnostics is growing rapidly, however cures for many congenital anomalies lag behind our diagnostic abilities. In developmental defects where babies are born with a disease phenotype, fetal therapy offers an opportunity to prevent or cure these disease. This is an opportunity that is lost after birth.

There are 3 broad aims of my basic science laboratory: 1) In Utero gene editing for the treatment of genetic diseases, 2) In Utero reversal of lung hypoplasia in diaphragmatic hernia 3) Minimally invasive In Utero therapy for spina bifida.

Selected Publications

  • Life-Long Transgene Expression in Skeletal Muscle Without Transduction of Satellite Cells Following Embryonic Myogenic Progenitor Transduction by Lentivirus Administered in Utero Stem Cells Dev. 2015 Aug 15;24(16):1878-87. doi: 10.1089/scd.2014.0585. Epub 2015 Jun 9.
  • Developmental stage determines efficiency of gene transfer to muscle satellite cells by in utero delivery of adeno-associated virus vector serotype 2/9 Mol Ther Methods Clin Dev. 2014 Sep 10;1:14040. doi: 10.1038/mtm.2014.40. eCollection 2014.
  • Robust in vivo transduction of nervous system and neural stem cells by early gestational intra amniotic gene transfer using lentiviral vector Mol Ther. 2010 Sep;18(9):1615-23. doi: 10.1038/mt.2010.125. Epub 2010 Jun 22.
  • The developmental stage determines the distribution and duration of gene expression after early intra-amniotic gene transfer using lentiviral vectors Gene Ther. 2010 Jan;17(1):61-71. doi: 10.1038/gt.2009.115. Epub 2009 Sep 3.

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Contact Info

David H Stitelman, MD
Patient Care Locations
Greenwich Hospital - 5 Perryridge Road
5 Perryridge Rd

Greenwich, CT 06830
Yale Surgery-Pediatric SurgeryYale-New Haven Hospital - West Pavilion
1 Park Street, Wing West Pavilion Ste 2nd Floor

New Haven, CT 06504
Yale Surgery- Pediatric Surgery747 Belden Avenue, Ste 1st Floor
Norwalk, CT 06850
Mailing Address
PO Box 208062
New Haven, CT 06520-8062

Curriculum Vitae