Abeel A. Mangi, MD

Associate Professor of Surgery (Section of Cardiac Surgery); Surgical Director, Center for Advanced Heart Failure, Mechanical Circulatory Support and Heart Transplantation; Surgical Director, Trans-Catheter Therapies

Departments & Organizations

Cardiomyopathy Inherited Cardiovascular Disease Program

Heart Failure & Transplant

Office of Student Research

Surgery: Cardiac Surgery: Yale Center for Advanced Heart Failure, Mechanical Circulatory Support, and Heart Transplantation

Yale Medical Group

Biography

Abeel A. Mangi, MD, is an attending surgeon in the Section of Cardiac Surgery at Yale University, and is Surgical Director of the Program in Trans-Catheter Therapies and Surgical Director of the Center for Advanced Heart Failure, Mechanical Circulatory Support and Cardiac Transplantation at the Yale New Haven Heart & Vascular Institute.

Dr. Mangi is certified and re-certified by the American Board of Surgery, and by the American Board of Thoracic Surgery. He is Associate Professor of Surgery at the Yale University School of Medicine.

He specializes in complex and re-operative cardiac surgery, trans-catheter valve repair and replacement, heart, heart-lung, and lung transplantation, ventricular assist devices, total artificial hearts, extracorporeal membrane oxygenation (ECMO), operations for heart failure, aortic and mitral valve repair and replacement, off-pump coronary bypass grafting, myectomy and the surgical treatment of hypertrophic cardiomyopathy, treatment of chronic pulmonary emboli, and ascending aortic and arch replacement.

Dr. Mangi has performed over 2,000 heart operations. His accomplishments include pioneering one of the first uses of VA-ECMO in an awake, ambulating patient as a successful bridge to lung transplantation; pioneering work in the area of trans-catheter valve replacement; recognizing the importance of surgical technique in avoiding LVAD failure; and investigating comparative cost-effectiveness of therapies for advanced heart failure. Under his leadership, volume of the transplant and mechanical circulatory support programs has quadrupled; while length of stay, morbidity and mortality have decreased, and quality has increased.

Dr. Mangi earned his undergraduate and medical degrees from Brown University. After completing his residency in general surgery at the Massachusetts General Hospital & Harvard Medical School, he was awarded a postdoctoral National Research Service Award fellowship from the National Institutes of Health, and won awards from the American Heart Association and the American College of Cardiology for ground-breaking stem cell research done at the Brigham & Women's Hospital and Harvard Medical School. He completed his fellowship in cardiac surgery at Columbia University and was then appointed as an Associate Staff Cardiac Surgeon at the Cleveland Clinic.

As principal or co-investigator in several clinical trials and studies, Dr. Mangi has focused his research efforts on his specialty interests, including trans-catheter repair and replacement of diseased heart valves; the surgical treatment of ischemic heart failure, cellular therapy to treat advanced heart damage and expanded roles for left ventricular assist devices (LVADs). He is also interested in quality of care in LVAD patients, and desensitization of recipients awaiting cardiac transplantation. He is prinicpal investigator on multiple clinical trials investigating catheter-based therapies for valvular heart disease and outcomes of patients supported on newer generation LVADs.

Dr. Mangi’s research group investigates important questions regarding variables that influence clinical outcomes for therapies for advanced heart failure. Large national databases such as the Interagency Registry for Mechanical Assisted Circulatory Support (INTERMACS), United Network for Organ Sharing (UNOS), Society for Thoracic Surgeons (STS) and the Nationwide Inpatient Sample (NIS) have been used to analyze cost and cost-effectiveness for such therapies, clinical prediction modeling, diversity and health equity issues, quality of life and access to care.

Dr. Mangi has been invited to speak about his clinical experience and research findings at conferences and symposia worldwide. He is the author or co-author of numerous book chapters on subjects related to his specialty interests, including advances in cardiac intensive care, cardiac surgery, assist devices and treatment of heart failure. He has authored or co-authored seventy published studies and abstracts in peer-reviewed publications, including Circulation, Nature Medicine, The Journal of Thoracic and Cardiovascular Surgery, and The Annals of Thoracic Surgery among others.

Dr. Mangi serves on multiple institutional, national and international committees, scientific advisory boards, and has been elected to membership and fellowship in the most esteemed organizations in his field including the International Society for Heart and Lung Transplantation, The American College of Cardiology, The Society for Thoracic Surgeons, The Society of University Surgeons, and The American College of Surgeons.

Education & Training

MD Brown University (1997)
BS Brown University, Biology (1993)
Fellow Columbia Presbyterian Medical Center
Senior Resident Massachusetts General Hospital & Harvard Medical School
Research Fellow Brigham & Women's Hospital & Harvard Medical School
Resident Massachusetts General Hospital & Harvard Medical School
Intern Massachusetts General Hospital & Harvard Medical School
Board Certification AB of Surgery, Surgery, General (2005)
Board Certification AB of Thoracic Surgery, Thoracic & Cardiac Surgery (2009)

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