Diseases; Analytical, Diagnostic and Therapeutic Techniques and Equipment; Phenomena and Processes; Technology, Industry, Agriculture; Health Care
Outcomes research: Our group investigates important questions regarding variables that influence clinical outcomes for therapies for advanced heart failure. We use large national databases such as the Interagency Registry for Mechanical Assisted Circulatory Support (INTERMACS), United Network for Organ Sharing (UNOS), Society for Thoracic Surgeons (STS) and the Nationwide Inpatient Sample (NIS). We analyze cost and cost-effectiveness for such therapies; clinical prediction modelling, diversity and health equity issues, quality of life and access to care.
Clinical trials: Dr. Mangi is Principal Investigator on five clinical trials investigating the expanded role for left ventricular assist devices, quality of care in LVAD patients, and desensitization of recipients awaiting cardiac transplantation. He is involved with three clinical trials investigating catheter based therapies for valvular heart disease in high risk patients. He has previously led an additional eight clinical trials looking at newer generation LVADs.