Diabetes Mellitus, Type 1; Endocrinology; Insulin; Insulin Infusion Systems; Pediatrics; Pancreas, Artificial
My research focuses on the application of new technologies to the treatment of diabetes. As part of my collaborations within the Diabetes Research in Children Network (DirecNet) and the Juvenile Diabetes Research Foundation Artificial Pancreas Project, I have been studying the safety, accuracy, and effectiveness of continuous glucose sensors to improve diabetes therapy, as well as investigating basic physiological questions of hypoglycemia counter-regulation. My main focus now is on the development of a so-called "artificial pancreas", in which an insulin pump automatically delivers the appropriate amount of insulin at any given time based upon receiving information from glucose sensor devices. I am also collaborating with several other pediatric endocrinologists and neuroimaging specialists to deterimne the effects of childhood diabetes on brain growth and function in children diagnosed with diabetes at a young age.
Specialized Terms: Insulin pump therapy; Continuous glucose sensors; Artificial pancreas
Glucose Outcomes with the In-Home Use of a Hybrid Closed-Loop Insulin Delivery System in Adolescents and Adults with Type 1 Diabetes
Garg SK, Weinzimer SA, Tamborlane WV, Buckingham BA, Bode BW, Bailey TS, Brazg RL, Ilany J, Slover RH, Anderson SM, Bergenstal RM, Grosman B, Roy A, Cordero TL, Shin J, Lee SW, Kaufman FR.Diabetes Technol Ther. 2017 Jan 30.
Safety of a Hybrid Closed-Loop Insulin Delivery System in Patients With Type 1 Diabetes
Bergenstal RM, Garg S, Weinzimer SA, Buckingham BA, Bode BW, Tamborlane WV, Kaufman FR. JAMA. 2016 Oct 4;316(13):1407-1408.
Outcome Measures for Artificial Pancreas Clinical Trials: A Consensus Report
Maahs DM, Buckingham BA, Castle JR, Cinar A, Damiano ER, Dassau E, DeVries JH, Doyle FJ 3rd, Griffen SC, Haidar A, Heinemann L, Hovorka R, Jones TW, Kollman C, Kovatchev B, Levy BL, Nimri R, O'Neal DN, Philip M, Renard E, Russell SJ, Weinzimer SA, Zisser H, Lum JW. Diabetes Care. 2016 Jul;39(7):1175-9.
Variations in Brain Volume and Growth in Young Children With Type 1 Diabetes.
Mazaika PK, Weinzimer SA, Mauras N, Buckingham B, White NH, Tsalikian E, Hershey T, Cato A, Aye T, Fox L, Wilson DM, Tansey MJ, Tamborlane W, Peng D, Raman M, Marzelli M, Reiss AL; Diabetes Research in Children Network (DirecNet). Diabetes. 2016. Feb;65(2):476-85.
Longitudinal assessment of neuroanatomical and cognitive differences in young children with type 1 diabetes: association with hyperglycemia.
Mauras N, Mazaika P, Buckingham B, Weinzimer S, White NH, Tsalikian E, Hershey T, Cato A, Cheng P, Kollman C, Beck RW, Ruedy K, Aye T, Fox L, Arbelaez AM, Wilson D, Tansey M, Tamborlane W, Peng D, Marzelli M, Winer KK, Reiss AL; Diabetes Research in Children Network (DirecNet). Diabetes. 2015 May;64(5):1770-9
Mitigating Meal-Related Glycemic Excursions in an Insulin-Sparing Manner During Closed-Loop Insulin Delivery: The Beneficial Effects of Adjunctive Pramlintide and Liraglutide
Sherr JL, Patel NS, Michaud CI, Palau-Collazo MM, Van Name MA, Tamborlane WV, Cengiz E, Carria LR, Tichy EM, Weinzimer SA.
Alterations in white matter structure in young children with type 1 diabetes.
Barnea-Goraly N, Raman M, Mazaika P, Marzelli M, Hershey T, Weinzimer SA, Aye T, Buckingham B, Mauras N, White NH, Fox LA, Tansey M, Beck RW, Ruedy KJ, Kollman C, Cheng P, Reiss AL; Diabetes Research in Children Network (DirecNet). Diabetes Care. 2014 Feb;37(2):332-40.
Neuroanatomical correlates of dysglycemia in young children with type 1 diabetes.
Marzelli MJ, Mazaika PK, Barnea-Goraly N, Hershey T, Tsalikian E, Tamborlane W, Mauras N, White NH, Buckingham B, Beck RW, Ruedy KJ, Kollman C, Cheng P, Reiss AL; Diabetes Research in Children Network (DirecNet). Diabetes. 2014 Jan;63(1):343-53.
Reduced hypoglycemia and increased time in target using closed-loop insulin delivery during nights with or without antecedent afternoon exercise in type 1 diabetes
Sherr JL, Cengiz E, Palerm CC, Clark B, Kurtz N, Roy A, Carria L, Cantwell M, Tamborlane WV, Weinzimer SA. Diabetes Care 2013; 36: 2909-14.
A randomized clinical trial to assess the efficacy and safety of real-time continuous glucose monitoring in the management of type 1 diabetes in young children aged 4 to <10 years.
Mauras N, Beck R, Xing D, Ruedy K, Buckingham B, Tansey M, White NH, Weinzimer SA, Tamborlane W, Kollman C. Diabetes Care 2012; 35: 204-210.
Feasibility of prolonged continuous glucose monitoring in toddlers with type 1 diabetes.
Tsalikian E, Fox L, Weinzimer SA, Buckingham B, White NH, Beck R, Kollman C, Xing D, Ruedy K. Pediatric Diabetes 2012; 13: 294-300.
Blunted counterregulatory hormone responses to hypoglycemia in young children and adolescents with well-controlled type 1 diabetes.
The Diabetes Research in Children Network (DirecNet) Study Group. Diabetes Care 2009; 32: 1954-9.
Fully automated closed-loop insulin delivery versus semiautomated hybrid control in pediatric patients with type 1 diabetes using an artificial pancreas
Weinzimer SA, Steil GM, Swan KL, Dziura J, Kurtz N, Tamborlane WV (May 2008) Diabetes care, 31(5)934-9
- Continuous glucose monitoring and intensive treatment of type 1 diabetes. JDRF CGM Study Group. N Engl J Med 2008; 359: 1464-76.
Full List of PubMed Publications
- Weinzimer SA: The "hop, skip, and jump": on exercise with a continuous glucose sensor device. Diabetes Technol Ther. 2004 Aug. PMID: 15321000
- Weinzimer SA: PENDRA: the once and future noninvasive continuous glucose monitoring device? Diabetes Technol Ther. 2004 Aug. PMID: 15320997