Michael Edwin Hodsdon MD, PhD

Associate Clinical Professor of Laboratory Medicine and Associate Professor of Pharmacology; Assoc. Director, Clinical Chemistry Laboratory

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Medicine, Pharmacology, and Physiology | Biochemistry, Biophysics and Structural Biology

Yale Medical GroupDevelopmental TherapeuticsStructural BiologyPharmacologyDiabetes Research Center | Laboratory Medicine: Clinical ChemistryDevelopmental Therapeutics

Research Interests

Biochemistry; Biophysics; Breast Cancer; Clinical Chemistry; Drug Metabolism; Health and Medicine; Laboratory Practice or Procedure; Nuclear Magnetic Resonance; Pathobiology; Pharmacology; Spectroscopy; Structural Biology; Toxicology more...


  • B.S., Indiana University, 1989
  • M.D./Ph.D., Washington University School of Medicine, St.Louis, 1997

Selected Publications

  • Kulkarni, M., Murphy, J.W., Tettamanzi, M.C., Keeler, C., Lolis, E., Myszka, D.G., and Hodsdon, M.E. (2010) Two histidines, one in prolactin and the other in its receptor, are responsible for pH-dependent receptor recognition and signal trandsuction. J. Biol. Chem., in press.
  • Petri, E.T, Celi, A., Kennedy, S.D., Ehrlich, B.E., Boggon, T. J. and Hodsdon, M.E. (2010) The structure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activity. Proc. Natl. Acad. Sci. U.S.A., 107(20), 9176 – 81.
  • Keeler, C., Tettamanzi, M.C., Meshack, S. and Hodsdon, M.E. (2009) Contribution of individual histidines to the global stability of human prolactin. Protein Science, 18, 909 – 920.



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