Anna Marie Pyle, PhD

Anna Marie Pyle is a Sterling Professor in the Departments of Molecular, Cellular and Developmental Biology and the Department of Chemistry.She has been a Howard Hughes Medical Institute Investigator since 1997. Dr. Pyle obtained her undergraduate degree in Chemistry from Princeton University and received her Ph.D. in Chemistry from Columbia University in 1990, where she worked with Professor Jacqueline Barton. Dr. Pyle was a postdoctoral fellow with Thomas Cech at the University of Colorado, forming her own research group in 1992 in the Department of Biochemistry and Molecular Biophysics at Columbia University Medical Center. In 2002, she moved to Yale University, where she leads a research group that specializes in structure and function of large RNA molecules, RNA remodeling enzymes and cellular RNA sensors. Dr. Pyle teaches the undergraduate Molecular Biology course and serves on the University Budget Committee at Yale. Dr. Pyle is the President of the RNA Society and she served as the Chair of the MSFA Study Section at the NIH after serving as permanent member on the MSFE, and MGB study sections. She is Vice-Chair of the Science and Technology Steering Committee at Brookhaven National Labs and she is on the Board of Telluride Science Research Center. She is involved in the development of RNA as a therapeutic and a drug target, serving on the SAB of Arrakis Therapeutics. Dr. Pyle is the author of over 190 publications and has mentored more than 40 graduate students and postdocs. The Pyle laboratory uses structural biology, enzymology and cell biology understand the structural complexity of large RNA molecules and the proteins that recognize them. She solved the first structures of pre-mRNA splicing machines, and led efforts to characterize RNA structures in noncoding RNAs and viral genomes. Dr. Pyle pioneered the study of RNA helicase enzymes and antiviral innate immune receptors in mammalian cells.