Valentina Greco, PhD

Associate Professor of Genetics, of Cell Biology and of Dermatology

Research Organizations

Cancer Center, Yale: Signal Transduction

Postnatal Development & Regeneration

Stem Cell Center, Yale: Stem Cell Niche and Homing | Tissue Specific Stem Cells

Research Summary

Stem cells and the microenvironment in which they reside - the so called niche - are central for the development and regeneration of all our organs, and their deregulation leads to a disease state. Despite the key relevance of stem cell niches and their conserved features, the dynamic interactions between stem cells and the niche are still not well understood.

The aim of my lab is to understand how stem cells and the niche contribute to tissue regeneration and what goes awry during disease states such as cancer using the murine skin hair follicle as a model system. The major challenge in studying these questions is the lack of accessibility to stem cell niches and consequently the inability to visualize the same stem cells over time to determine their specific behavior and long-term fate.

My laboratory has recently established the ability to study cellular mechanisms, in real-time, within an intact stem cell niche during physiological hair follicle regeneration in live mice. My lab integrates cell biology, genetics, genomics and two-photon imaging of live mice to understand 1) the functional role that stem cell niche components exert during hair follicle regeneration, 2) the signaling mechanisms that control hair follicle stem cell behaviors and 3) how basic mechanisms of hair follicle regeneration are hijacked during disease such as skin cancer.

Selected Publications

Edit this profile

Valentina Greco, PhD

Associate Professor of Genetics, of Cell Biology and of Dermatology

Research Organizations

Cancer Center, Yale: Signal Transduction

Postnatal Development & Regeneration

Stem Cell Center, Yale: Stem Cell Niche and Homing | Tissue Specific Stem Cells

Research Summary

Stem cells and the microenvironment in which they reside - the so called niche - are central for the development and regeneration of all our organs, and their deregulation leads to a disease state. Despite the key relevance of stem cell niches and their conserved features, the dynamic interactions between stem cells and the niche are still not well understood.

The aim of my lab is to understand how stem cells and the niche contribute to tissue regeneration and what goes awry during disease states such as cancer using the murine skin hair follicle as a model system. The major challenge in studying these questions is the lack of accessibility to stem cell niches and consequently the inability to visualize the same stem cells over time to determine their specific behavior and long-term fate.

My laboratory has recently established the ability to study cellular mechanisms, in real-time, within an intact stem cell niche during physiological hair follicle regeneration in live mice. My lab integrates cell biology, genetics, genomics and two-photon imaging of live mice to understand 1) the functional role that stem cell niche components exert during hair follicle regeneration, 2) the signaling mechanisms that control hair follicle stem cell behaviors and 3) how basic mechanisms of hair follicle regeneration are hijacked during disease such as skin cancer.

Selected Publications

Edit this profile

Contact Info

Valentina Greco, PhD
Mailing Address
Department of Genetics315 Cedar Street
SHM I wing 336B

New Haven, CT 06510

Greco Lab

Contact Info

Valentina Greco, PhD
Mailing Address
Department of Genetics315 Cedar Street
SHM I wing 336B

New Haven, CT 06510

Greco Lab