Agnès M C Vignery DDS, PhD

Senior Research Scientist in Orthopaedics and Rehabilitation and in Cell Biology

Departments & Organizations

Yale Combined Program in the Biological and Biomedical Sciences (BBS): Molecular Cell Biology, Genetics and Development

Office of Student ResearchStem Cell Center, Yale: Stem Cell Niche and HomingVascular Biology and Therapeutics ProgramCell Biology: Membrane Traffic; Developmental Cell Biology and GeneticsOrthopaedics and RehabilitationImmunology and Immunotherapy

Research Interests

Differentiation mechanism of osteoblasts; Fusion mechanism of macrophages more...


  • D.D.S., University of Paris, 1972
  • Ph.D., University of Paris, 1975

Selected Publications

  • Kcnn4 is a regulator of macrophage multinucleation in bone homeostasis and inflammatory disease. Kang H, Kerloc'h A, Rotival M, Xu X, Zhang Q, D'Souza Z, Kim M, Scholz JC, Ko JH, Srivastava PK, Genzen JR, Cui W, Aitman TJ, Game L, Melvin JE, Hanidu A, Dimock J, Zheng J, Souza D, Behera AK, Nabozny G, Cook HT, Bassett JH, Williams GR, Li J, Vignery A, Petretto E, Behmoaras J. Cell Rep. 2014 Aug 21;8(4):1210-24. doi: 10.1016/j.celrep.2014.07.032. Epub 2014 Aug 14. PMID: 25131209 [PubMed - in process]
  • Additive Effects of Mechanical Marrow Ablation and PTH Treatment on de Novo Bone Formation in Mature Adult Rats. Zhang Q, Miller C, Bible J, Li J, Xu X, Mehta N, Gilligan J, Vignery A, Scholz JA. Cells. 2012 Dec 5;1(4):1168-81. doi: 10.3390/cells1041168. PMID: 24710549 [PubMed]
  • Jin C, Frayssinet P, Pelker R, Cwirka D, Hu B, Vignery A, Eisenbarth SC, Flavell RA. NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy. Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14867-72. Epub 2011 Aug 19.



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