Qin Yan, PhD

Associate Professor of Pathology

Research Organizations

Cancer Genetics & Genomics

Pathology: Yan Lab

Stem Cell Center, Yale: Transcriptional Regulation of Stem and Progenitor Cells

Research Summary

Epigenetic aberrations often lead to cancer and other human diseases. Our laboratory is interested in dissecting the roles of epigenetic regulators in cancer and stem cells. In particular, we focus on the roles and regulatory mechanisms of histone demethylases for tri- methylated lysine 4 in histone H3 (H3K4me3), the epigenetic mark for transcriptionally active chromatin. We have previously showed RBP2/JARID1A is one of the first known histone demethylases for H3K4me3. Using the RBP2 knockout mouse model, we further showed that loss of RBP2 inhibits tumorigenesis in several genetically-engineered mouse models. We are currently studying how this enzyme contributes to oncogenesis using a combination of biochemical, molecular biological, cell biological and mouse genetic approaches. We are also investigating the roles of another H3K4me3 histone demethylase PLU1/JARID1B. These enzymes are potential drug targets for epigenetic therapies against cancer, and we have developed first generation inhibitors against these enzymes.

Selected Publications

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Qin Yan, PhD

Associate Professor of Pathology

Research Organizations

Cancer Genetics & Genomics

Pathology: Yan Lab

Stem Cell Center, Yale: Transcriptional Regulation of Stem and Progenitor Cells

Research Summary

Epigenetic aberrations often lead to cancer and other human diseases. Our laboratory is interested in dissecting the roles of epigenetic regulators in cancer and stem cells. In particular, we focus on the roles and regulatory mechanisms of histone demethylases for tri- methylated lysine 4 in histone H3 (H3K4me3), the epigenetic mark for transcriptionally active chromatin. We have previously showed RBP2/JARID1A is one of the first known histone demethylases for H3K4me3. Using the RBP2 knockout mouse model, we further showed that loss of RBP2 inhibits tumorigenesis in several genetically-engineered mouse models. We are currently studying how this enzyme contributes to oncogenesis using a combination of biochemical, molecular biological, cell biological and mouse genetic approaches. We are also investigating the roles of another H3K4me3 histone demethylase PLU1/JARID1B. These enzymes are potential drug targets for epigenetic therapies against cancer, and we have developed first generation inhibitors against these enzymes.

Selected Publications

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Contact Info

Qin Yan, PhD
Office Location
Department of PathologyBrady Memorial Laboratory
310 Cedar Street, Ste BML 348C

New Haven, CT 06510
Mailing Address
310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Yan lab

Contact Info

Qin Yan, PhD
Office Location
Department of PathologyBrady Memorial Laboratory
310 Cedar Street, Ste BML 348C

New Haven, CT 06510
Mailing Address
310 Cedar Street
PO Box 208023

New Haven, CT 06520-8023

Yan lab