Patrick G Gallagher MD

Professor of Pediatrics (Neonatology), of Genetics and of Pathology; Director, Yale Center for Blood Disorders

Research Interests

Neonatal hematology; Erythropoiesis; Inherited abnormalities of the erythrocyte including metabolic, membrane, and hemoglobin disorders; Sickle cell disease; Hereditary spherocytosis; Elliptocytosis; Pyropoikilocytosis; Stomatocytosis

Research Summary

Dr. Gallagher’s research focuses on the genetic basis of inherited disorders of the erythrocyte and the molecular control of erythropoiesis. Dr. Gallagher’s research is funded by the NIH and private foundations. Current NIH support includes two R01 awards, ARRA supplements, and P30 support for the Yale Center for Excellence in Molecular Hematology (YCEMH). Dr. Gallagher is PI of the Expression and Genomics Core of the YCEMH. He is also supported by an Innovation in Clinical Research Award from the Doris Duke Foundation. Dr. Gallagher is fully engaged in the Yale scientific community, with a joint appointment in Genetics, and active membership in both the Yale Stem Cell Center and the Yale Cancer Center. He is director of the Yale Center for Blood Disorders.

Current extramural activities include Editorial Board service for the Journal of Biological Chemistry, the American Journal of Hematology, Pediatric and Developmental Pathology, BMC Pregnancy and Childbirth (Associate Editor), and Blood Cells, Molecules and Disease and grant and abstract reviewing for numerous NIH, private foundations, and academic society meetings including PAS. He recently finished a two-year-term as chair of the NIH Erythrocyte and Leukocyte Biology Study Section and is currently chair of the American Society of Hematology Scientific Subcommittee on Hemoglobin/Red Cell.

Extensive Research Description

Dr. Gallagher has trained numerous undergraduate, graduate and medical students, MD and PhD postdoctoral fellows, and sabbatical faculty. Laboratory graduates hold positions throughout the world and trainees have received awards and honors from local, regional, and national organizations. In addition to this T32, he participates in training grants in Genetics, Pathology and Medicine. He serves on the Department of Pediatrics Scholarship Oversight Committee (SOC). He has served on numerous individual SOCs as member or chair, as well as various medical and graduate school mentoring committees, PhD thesis committees, etc. Directing the Perinatal Medicine fellowship is a vital part of Dr. Gallagher’s activities as a Yale Medical School faculty member.

Selected Publications

  • Su MY, Steiner LA, Bogardus H, Mishra T, Schulz VP, Hardison RC, Gallagher PG. (2013). Identification of Biologically Relevant Enhancers in Human Erythroid Cells. J Biol Chem 2013; 288:8433-44.PMID: 23341446
  • Harper SL, Sriswasdi S, Tang HY, Gaetani M, Gallagher PG, Speicher DW. The common hereditary elliptocytosis-associated a-spectrin L260P mutation perturbs erythrocyte membranes by stabilizing spectrin in the closed dimer conformation. Blood. 2013; In press. PMID: 23974198
  • Yocum, AO, Steiner, LA, Seidel, NE, Cline, AP, Rout, ED, Lin, JY, Wong, C, Garrett, LJ, Gallagher, PG, Bodine, DM. (2012). A tissue-specific chromatin loop activates the erythroid ankyrin-1 promoter. Blood, 120, 3586-3593. PMCID: 3482866
  • Zarychanski R, Schulz VP, Houston BL, Maksimova Y, Houston DS, Smith B, Rinehart J, Gallagher PG: Mutations in the mechanotransduction protein PIEZO1 are associated with hereditary xerocytosis. Blood 2012; 120:1908-15. PMCID: PMC3448561.
  • Walker RH, Schulz VP, Tikhonova IR, Mahajan MC, Mane S, Arroyo Muniz M, Gallagher PG: Genetic diagnosis of neuroacanthocytosis disorders using exome sequencing. Mov Disord 2012; 27:539-43. PMID: 22038564. PMCID: PMC Journal - In Process.
  • Steiner LA, Schulz VP, Maksimova Y, Wong C, Gallagher PG: Patterns of histone H3 lysine 27 mono-methylation and erythroid cell-type specific gene expression. J Biol Chem 2011; 286:39453-65. PMCID: PMC3234769.
  • Stewart AK, Shmukler BE, Vandorpe DH, Rivera A, Li X, Hsu A, Karpatkin M, O'Neill A, Bauer DE, Heeney M, John K, Kuypers FA, Gallagher PG, Lux SE, Brugnara C, Westhoff CM, Alper SL: Loss-of-function and gain-of-function phenotypes of stomatocytosis mutant RhAG F65S. Am J Physiol Cell Physiol 2011; 301:C1325-43. PMCID: PMC3233792.
  • Su MY, Steiner LA, Bogardus H, Mishra T, Schulz VP, Hardison RC, Gallagher PG. (2013). Identification of Biologically Relevant Enhancers in Human Erythroid Cells. J Biol Chem 2013; 288:8433-44.PMID: 23341446

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