Yale has a strong group of established scientists who work on stem cells, as well as scholars whose work focuses on the policies and bioethics in stem cell research. The efforts new faculty recruits to the YSCP will complement the existing research strengths at Yale, and will enhance the research by providing a nidus for research activity as well as core facilities in which stem cell work can be done with adult stem cells and with human embryonic stem cells.
Stem cells, by definition, are capable of indefinite self-renewal and as well as differentiation into at least mature cell type. When a stem cell self-renews, it undergoes symmetrical division to produce 2 identical daughter cells. In contrast, when a stem cell undergoes differentiation, it can do so either by directly changing its gene expression pattern or by undergoing asymmetrical division in which one daughter cells in identical to the stem cell and the other daughter cell is differentiated or about to undergo differentiation. Many laboratories at Yale are focused on some aspect of stem cell self-renewal and/or differentiation with research ranging from basic science to clinical trials to clinical practice.
Amongst the many important lines of scientific inquiry are:
- Fertilization & Embryogenesis
- RNA & Transcriptional Regulation of Stem Cells
- Signal Transduction & Cell Growth
- Stem Cell Genetics
- Stem Cell Niche & Homing
- Stem Cell Self-Renewal & Asymmetry
- Tissue-Specific Stem Cells & Cell Therapy
One of the primary goals of the Yale Stem Cell Center is to promote cross-fertilization amongst the member laboratories, which will lead to more fruitful research, serendipitous discoveries, and increased funding opportunities.