Antonio J. Giraldez, PhD

Professor of Genetics; Member of the Yale Cancer Center; Member of the Stem Cell Center; Director of Graduate Studies; Graduate program in Computational Biology and Bioinformatics,

Research Interests

Zebrafish; Developmental Biology; Gene Expression Regulation, Developmental; Computational Biology; Genomics; Systems Biology

Research Organizations

Cancer Center, Yale: Genomics, Genetics, and Epigenetics

Center for RNA Science and Medicine, Yale

Gene Regulation and Functional Genomics

Small RNAs in Development

Stem Cell Center, Yale: Stem Cell Genetics

Office of Cooperative Research

Research Summary

In our laboratory we investigate how gene regulation shapes vertebrate embryonic development using zebrafish as a model system. We combine genomics, genetics, embryology, chemical and computational biology to address a central question in biology: how does a fertilized egg develop into a complex multicellular embryo. This process requires a precise spatial and temporal regulation of gene expression. We are primarily focused on understanding the mechanisms that activate the genome soon after fertilization and how this universal transition drives post-transcriptional regulation of the maternal instructions to allow one of the central developmental transitions to occur.

Selected Publications

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