Postdoctoral Position in Retinal Stem Cell Research

A position is available Sept. 1, 2010 to study the development of the outer retina using human embryonic stem cells.  During differentiation, the retinal pigment epithelium (RPE) matures in response to the differentiation of retinal neurons.  To study this process, we are engineering a three-dimensional culture model of the outer retina.  Current projects examine the electrophysiology, morphology and transcriptome of the cultures with the aim of developing tissues suitable for transplantation into diseased eyes.  Contact: Larry Rizzolo, Dept. of Surgery/Anatomy, Yale Univ. Sch. of Med., 310 Cedar St., PO Box 208062, New Haven, CT 06520-8062.

Recent Publications

  1. Rizzolo, L.J. (2007) Development and Role of Tight Junctions in the Retinal Pigment Epithelium Int. Rev. Cytol. 258:195-234. PMID: 17338922
  2. Rizzolo L.J., Chen X., Weitzman M., Sun R. and Zhang H. (2007) Analysis of the RPE transcriptome reveals dynamic changes during the development of the outer blood-retinal barrier. Mol. Vis. 13:1259-1273. PMID: 17679949
  3. Sun R., Peng, S., Chen X., Zhang H. and Rizzolo L.J. (2008) Diffusible retinal secretions regulate the expression of tight junctions and other diverse functions of the retinal pigment epithelium. Mol. Vis. 14:2237-2262. PMCID: PMC2593753
  4. Cong L, Sun D, Zhang  Z, Jiao W, Rizzolo LJ and Peng S (2008) A novel rabbit model for studying RPE transplantation.  Invest. Opthalmol. Vis. Sci.49:4115-4125. PMCID: PMC2568003
  5. Peng S., Adelman R., and Rizzolo L.J. (2010) VEGF and Anti-VEGF drugs have minimal effects on the permeability or selectivity of RPE tight junctions. Invest. Ophthalmol. Vis. Sci.: 51:3216-3225 PMID: 20042644