A postdoctoral position is available in the area of cardiovascular (CV) stem cell biology. We are striving to ameliorate heart diseases utilizing a novel population of CV stem cells, coupled with embryonic stem cells, high-throughput chemical screening and tissue engineering. Current ongoing projects cover the following areas:
1. Characterize novel signaling pathways implicated in the regulation of this novel population of CV stem cells (Laugwitz et al., Nature 433, 647-53; Qyang et al., Cell Stem Cell 1, 165-79, 2007).
2. Derive CV stem cells from human embryonic stem cells and patient specific stem cells, utilize bio-degradable scaffold to establish engineered heart tissues (EHT) with these cells, and examine their contribution to heart repair and regeneration in animal models.
3. Establish assays for high-throughput small molecule screens to directly reprogram heart fibroblast (scar-forming cells) and quiescent adult epicardial cells into CV stem cells, respectively.
Essential Qualifications: The successful candidate must have a doctoral degree in related areas. General knowledge and techniques in molecular and cellular biology are required.
Preferred Qualifications: Experience in studying developmental biology, especially heart development, with murine or other animal models is preferable, but not required.
Interested candidates should submit their CV including names and contact information for three references and a short description of their doctoral training and future research goals.
Dr. Yibing Qyang
Yale Cardiovascular Research Institute and
Section of Cardiology, Dept. of Internal Medicine
Yale Stem Cell Center
TAC S-310, Yale University School of Medicine
300 Cedar Street
New Haven, CT 06519