The lab of Craig Crews, Ph.D., Department of Molecular, Cellular and Developmental Biology at Yale is inviting applications for multiple postdoctoral positions. With an emphasis on regenerative medicine, the lab investigates the inductive role of the wound epidermis on cellular dedifferentiation during amphibian limb regeneration.
Our research has recently revealed key genes that are specifically expressed in the regenerating epidermis of the Mexican salamander (aka, the Axolotl). Several of these genes encode secreted or membrane-bound proteins that may play a role in inducing/maintaining the dedifferentiated state of the underlying mesenchyme during regeneration and thus may serve as a natural analogy for the induction of iPS cells. We are exploring the roles of these proteins using both cell culture-based assays and in vivo/transgenic expression analyses. These projects are partly supported by the NIH and the Ellison Medical Foundation.
A successful candidate should be self-motivated with a strong background and experimental skills in molecular biology, cell biology, and/or developmental biology, as well as a track record of publication. Previous experiences in aforementioned fields are welcome but not required. Interested applicants please send CV and contact information of three referees to:
Craig Crews, Ph.D.
Department of Molecular, Cellular and Developmental Biology
P.O. Box 208103
New Haven, CT 06520-8103
Gene expression profile of the regeneration epithelium during axolotl limb regeneration.
Campbell LJ, Suárez-Castillo EC, Ortiz-Zuazaga H, Knapp D, Tanaka EM, Crews CM.
Dev Dyn. 2011 Jul;240(7):1826-40.
Wound epidermis formation and function in urodele amphibian limb regeneration.
Campbell LJ, Crews CM.
Cell Mol Life Sci. 2008 Jan;65(1):73-9