Positions in the laboratory of Dr. Diane Krause
The laboratory of Diane Krause M.D. Ph.D., Associate Director of the Yale Stem Cell Center, and Professor of Laboratory Medicine at Yale University School of Medicine, has 3 open postdoctoral positions.
The overall goals of research in the Krause laboratory are to define the molecular mechanisms that regulate hematopoiesis and leukemogenesis using bone marrow derived stem and progenitor cells with the goal of translating the findings to improved strategies for bone marrow/stem cell transplantation as well as for developing novel strategies for treating leukemia and lymphoma.Current projects are focused on megakaryocytic differentiation and parallels between cell cycle regulation in normal diploid cells, polyploidization of megakaryocytes, and malignant tranformation of hematopoietic progenitor cells leading to acute megakaryoblastic leukemia.
Projects include studies of notch signalling, the MKL1/SRF signal transduction pathway, the role of nuclear and cytoplasmic actin polymerization in megakaryocyte differentiation, G protein signaling and epigenetic regulation of hematopoietic differentiation.In addition, my laboratory is studying rare bone marrow subpopulations in order to determine the which bone marrow-derived cells can differentiate into epithelial cells (termed adult cell plasticity) and we are assessing how this occurs in response to tissue damage with a focus on type II pneumocyte engraftment in the lung.
Successful candidates should be highly self-motivated with the drive to pursue a career in academic research. Requirements include a strong background in cell and molecular biology, as well as a track record of first author publications in English journals. Previous experience in hematopoiesis, stem cell biology and/or lung biology are suggested, but not required. The Yale Stem Cell Center provides a stimulating and collaborative training environment, as well as cutting edge facilities. Interested applicants should send CV and contact information of three referees to:
Yale Stem Cell Center, Rm 237
10 Amistad Street
New Haven, CT 06519