Yale Stem Cell Center is pleased to announce the 2015 recipients of “The Lo Graduate Fellowship for Excellence in Stem Cell Research” (abbreviated as “The Lo Fellowship”) for outstanding senior graduate students pursuing stem cell research at Yale University. This one-year fellowship is made possible by a generous gift of endowment from the KS & Feili Lo Foundation. It is Yale Stem Cell Center’s most prestigious graduate award, and is designed to recognize and support graduate students with demonstrated passion and achievement in stem cell research. Three awards were given this year to partially defray each recipient’s stipend, with funding beginning on September 1, 2015.
Charles Hernandez, graduate student in the laboratory of Natalia Ivanova in the Department of Genetics is conducting research on the epigenetic mechanisms that govern transcription factor reprogramming, specifically the proteins of Dppa2/4 family and their role in enhancing cellular reprogramming.
Christine Roden, graduate student in the laboratory of Jun Lu in the Department of Genetics is conducting research to understand the regulation of miR-125 family and by extension an important target gene, TET2, in the hematopoietic system.
Meng Zhang, graduate student in the laboratory of Haifan Lin in the Department of Cell Biology is studying the regulation of mouse neural stem cells by pumilio proteins.
The Lo Graduate Fellowship for Excellence in Stem Cell Research Selection Committee has chosen two graduate students to receive this prestigious award in 2014.
Each student will receive a one-year fellowship in the amount of $19,000. The program funding will begin on September 1, 2014. This Fellowship is made possible by a generous gift of endowment to the Yale Stem Cell Center from the K.S. & Feili Lo Foundation.
Elise Jeffery, a student in the laboratory of Matthew Rodeheffer in the Section of Comparative Medicine and the Department of Molecular, Cellular and Developmental Biology, was selected for her work on the cellular and molecular mechanisms by which resident adipocyte precursor cells respond to high fat diet. Elise’s work has identified that adipocyte stem cells are activated to increase adipocyte number in obesity by a mechanism that is distinct from adipocyte formation during development. This is a major advance in the obesity field and our understanding of the mechanisms that lead to weight gain.
Rachel Zwick, a student in the laboratory of Valerie Horsley, in the Department of Molecular, Cellular and Developmental Biology, was selected for her work on a fundamental question of how adipocytes grow and shrink, which occurs during obesity and in other tissues such as the skin. Rachel has developed a novel proposal that employs techniques my laboratory developed to analyze adipocytes in the skin and the power of mouse genetics to lineage trace adipocyte lineage cells in the mammary gland. These studies will have implications for multiple tissues where adipocytes reside and may have implications for mammary gland biology during pregnancy and tumorigenesis.
He is working in the laboratory of Dr. Matthew Rodeheffer in the Section of Comparative Medicine investigating the cellular and molecular mechanisms regulating hyperplastic white adipose tissue (aka “fat”) growth that leads to obesity.
She is working in the laboratory of Dr. Haifan Lin in the Department of Cell Biology and the Yale Stem Cell Center investigating the molecular mechanism of Tudor-SN, a Piwi interacting protein, regulates Piwi expression.
These students will each be given awards in the amount of $19,845 to partially defray their stipends, with funding beginning on September 1, 2013.
- Xiaowei Chen - She is working in the laboratory of Dr. Frank Slack in the Department of Computational Biology and Informatics, investigating LIN28 interacting mRNAs and miRNAs to advance the understanding of the basic aspects of stem cells and improve the method to promote pluripotent stem cells in somatic cells.
- Elizabeth Deschene - She is working in the laboratory of Dr. Valentina Greco in the Department of Genetics, investigating the signaling and cellular mechanisms that govern stem cell activation during tissue regeneration by combining mouse genetic models with a novel 2-photo, in vivo imaging approach.