Findings

A promising vaccine

Engineered protein gives mice complete protection, could lead to a diagnostic test.

A vaccine developed by Yale scientists has protected mice from the West Nile virus, a mosquito-borne infection that has been linked to about 10 deaths in the United States since the summer of 1999.

The virus, first identified in Uganda in 1937, surfaced in the New York City area in 1999 and has subsequently appeared in the South and Midwest. It is considered an emerging disease, said Erol Fikrig, M.D., associate professor of medicine and of epidemiology and public health. “Its seriousness as a public health threat is not fully known yet,” said Fikrig, who directed the development of the vaccine. “That should become apparent over the next two to three years. If the vaccine proves necessary, its development will be valuable.”

The virus, which infects birds as well as humans, spreads through mosquito bites primarily in warm-weather months. There is currently no cure, although infection does...

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Molecule that targets tissue factor is found to thwart tumors in mice

Yale researchers have developed a molecule that, when injected into tumors in mice, destroyed blood vessels in tumors and left normal tissue unharmed. Their findings, published in the October 9 issue of Proceedings of the National Academy of Sciences, hold the promise of a new therapy for metastatic cancer.The molecule, developed by Alan Garen, Ph.D., and Zhiwei Hu, Ph.D., in the Department of Molecular Biophysics...

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Knock-out study shows how some white blood cells regulate skin cancer

A type of white blood cell that is found in the skin and assists in the body’s immune response also helps prevent skin...

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Route of infection

Investigators in microbial pathogenesis have described a secretion system that many bacteria—including those that cause...

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Crossing over

Two Yale neuroscientists have discovered a pathway, apparently unique to humans, that guides neurons between different...

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Clues to how a cell moves

Using X-ray crystallography, investigators at Yale and the Salk Institute have solved the structure of Arp2/3, a...

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