Follow-Up

Antibiotic-resistant ribosomes unmasked

Five years ago, Yale scientists made a splash with the long-sought atomic structure of the large subunit of the ribosome, the protein-synthesizing factory of the cell and a target for many antibiotics (See “Yale Researchers Solve Structure of the Ribosome,” Fall 2000/ Winter 2001). It was the largest asymmetric structure to be solved up to that time, and the work, coming from the laboratories of Thomas A. Steitz, Ph.D., Sterling Professor of Molecular Biophysics and Biochemistry and a Howard Hughes Medical Institute investigator, and Peter B. Moore, Ph.D., Sterling Professor of Chemistry and professor of molecular biophysics and biochemistry, settled many long-standing questions about protein synthesis.This...

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